Background
Methods
Patients and tissue specimens
qRT-PCR
Statistical analysis
Results
HSPA2 mRNA upregulation in pancreatic cancer
Variables
|
No. of cases (n = 104)
|
HSPA2 mRNA expression
|
P
-value
| |
---|---|---|---|---|
Low (n, %)
|
High (n, %)
| |||
Age (years) | 0.484 | |||
<60 | 43 | 21 (48.8) | 22 (51.2) | |
≥60 | 61 | 28 (44.3) | 33 (54.1) | |
Gender | 0.396 | |||
Male | 82 | 37 (45.1) | 45 (54.9) | |
Female | 22 | 12 (54.5) | 10 (45.5) | |
Tumor size (cm) | 0.024 | |||
<2 | 47 | 32 (68.1) | 15 (31.9) | |
≥2 | 57 | 17 (29.8) | 40 (70.2) | |
Histological grades | 0.012 | |||
Well/Moderate | 56 | 32 (57.0) | 24 (43.0) | |
Poor | 48 | 17 (35.4) | 31 (64.6) | |
TNM stagea
| 0.006 | |||
IA-IB | 66 | 35 (53.0) | 31 (47.0) | |
IIA-IIB | 38 | 14 (36.8) | 24 (63.2) | |
Lymph node metastasis | 0.043 | |||
No | 75 | 39 (48.0) | 36 (52.0) | |
Yes | 29 | 10 (44.8) | 19 (55.2) | |
Vascular invasion | 0.062 | |||
No | 80 | 39 (48.8) | 41 (51.2) | |
Yes | 24 | 10 (41.7) | 14 (58.3) | |
CA19-9 (U/ml) | 0.046 | |||
<27 | 27 | 14 (51.9) | 13 (48.1) | |
≥27 | 77 | 35 (45.5) | 42 (54.5) | |
Bilirubin (μmol/l) | 0.178 | |||
<17.1 | 35 | 16 (45.7) | 19 (54.3) | |
≥17.1 | 69 | 33 (47.8) | 36 (52.3) |
Association between HSPA2 mRNA upregulation and clinicopathological parameters of patients with pancreatic cancer
Association between HSPA2 mRNA upregulation and poor prognosis in patients with pancreatic cancer
Variables
|
Univariable
P
-value (log-rank test)
|
Multivariable
| |
---|---|---|---|
HR (95% CI)
|
P
-value
| ||
Age at diagnosis (years) | |||
<60 vs. ≥60 | 0.584 | ||
Gender | |||
Male vs. Female | 0.763 | ||
Tumor size (cm) | |||
<2 vs. ≥2 | 0.082 | ||
Histological grades | |||
Well/Moderate vs. Poor | 0.067 | ||
TNM stagea
| |||
IA-IB vs. IIA-IIB | 0.013 | 1.23 (1.14-1.52) | 0.026 |
Lymph node metastasis | |||
No vs. Yes | 0.040 | 1.14 (0.97-1.41) | 0.054 |
Vascular invasion | |||
No vs. Yes | 0.017 | 1.27 (1.04-1.49) | 0.042 |
CA19-9 (U/ml) | |||
<27 vs. ≥27 | 0.082 | ||
Bilirubin (μmol/l) | |||
<17.1 vs. ≥17.1 | 0.185 | ||
HSPA2 mRNA expression | |||
Low vs. High | 0.007 | 1.58 (1.11-1.89) | 0.011 |