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Acta Neurochirurgica

Erschienen in:

01.02.2010 | Experimental Research

Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater

verfasst von: Ulrich J. Knappe, Thomas Fink, Annette Fisseler-Eckhoff, Robert Schoenmayr

Erschienen in: Acta Neurochirurgica | Ausgabe 2/2010

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Abstract

Purpose

To describe the pattern of expression of extracellular matrix (ECM) proteins in perisellar connective tissue.

Methods

Dural and perisellar specimens from ten individuals were investigated immunohistochemically for collagens I to IV, tenascin, fibronectin, elastin, laminin, and vitronectin.

Findings

Collagen I and III and fibronectin were strongly expressed and collagen IV, tenascin, and vitronectin were moderately expressed in the boundaries of the sella and around the CS. In six of nine specimens from the anterior boundary of the sella, and in 11 of 19 samples from the lateral boundary of the sella (medial wall of CS), two different layers could be detected by the expression of different ECM proteins. None of the antigens generally allowed differentiation between two layers of the pituitary envelope.

Conclusions

The pituitary boundary may consist of a single or a double layer, infrequently differentiated from each other by the expression of different ECM proteins.

Beier UH, Holtmeier C, Weise JB, Gorogh T (2007) Fibronectin suppression in head and neck cancers, inflammatory tissues and the molecular mechanisms potentially involved. Int J Oncol 30:621–629PubMed

Campero A, Martins C, Yasuda A, Rhoton AL Jr (2008) Microsurgical anatomy of the diaphragma sellae and its role in directing the pattern of growth of pituitary adenomas. Neurosurgery 62:717–723CrossRefPubMed

Destrieux C, Kakou MK, Velut S, Lefrancq T, Jan M (1998) Microanatomy of the hypophyseal fossa boundaries. J Neurosurg 88:743–752CrossRefPubMed

Dietemann JL, Kehrli P, Maillot C, Diniz R, Reis M Jr, Neugroschl C, Vinclair L (1998) Is there a dural wall between the cavernous sinus and the pituitary fossa? anatomical and MRI findings. Neuroradiology 40:627–630CrossRefPubMed

Dreiling FJ, Henson MM, Henson OW (2002) Immunolabeling type II collagen in the basilar membrane, a pre-embedding approach. Hear Res 166:181–191CrossRefPubMed

Farnoud MR, Kujas M, Derome P, Racadot J, Peillon F, Li JY (1994) Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas. An immunohistochemical study. Virchows Arch 424:75–82CrossRefPubMed

Felix A, Rosa JC, Fonseca I, Cidadao A, Soares J (2004) Pleomorphic adenoma and carcinoma ex pleomorphic adenoma: immunohistochemical demonstration of the association between tenascin expression and malignancy. Histopathology 45:187–192CrossRefPubMed

Garibi J, Pomposo I, Villar G, Gaztambide S (2002) Giant pituitary adenomas: clinical characteristics and surgical results. Br J Neurosurg 16:133–139CrossRefPubMed

Honegger J, Prettin C, Feuerhake F, Petrick M, Schulte-Mönting J, Reincke M (2003) Expression of Ki-67 antigen in non-functioning pituitary adenomas: correlation with growth velocity and invasiveness. J Neurosurg 99:674–679CrossRefPubMed

10.

Horton WA, Dwyer C, Goering R (1983) Immunohistochemistry of types I and II collagen in undecalcified skeletal tissues. J Histochem Cytochem 31:417–425PubMed

11.

Hussaini IM, Trotter C, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, Agi CU, Redpath GT, Fang Z, Leung GK, Lopes MB, Laws ER (2007) Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and non-invasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Am J Pathol 170:356–365CrossRefPubMed

12.

Ikeda H, Yoshimoto T, Fujiwara K, Ogawa Y (1995) Immunohistochemical demonstration of tenascin in human pituitary glands and adenomas. Acta histochem (Jena) 97:273–280

13.

Kawamoto H, Uozumi T, Kawamoto K, Arita K, Yano Y, Hirohata T (1996) Type IV collagenase activity and cavernous sinus invasion in human pituitary adenomas. Acta Neurochir (Wien) 138:390–395CrossRef

14.

Knappe UJ, Luedecke DK (1996) Transnasal microsurgery in children and adolescents with Cushing`s disease. Neurosurgery 39:484–493CrossRefPubMed

15.

Knappe UJ, Hagel C, Lisboa BW, Wilczak W, Luedecke DK, Saeger W (2003) Expression of serine proteases and metalloproteinases in human pituitary adenomas and anterior pituitary lobe tissue. Acta Neuropathol 106:471–478CrossRefPubMed

16.

Knappe UJ, Konerding MA, Schoenmayr R (2009) Medial wall of the cavernous sinus: microanatomical diaphanoscopic and episcopic investigation. Acta Neurochir (Wien) 151:961–967CrossRef

17.

Knappe UJ, Jaursch-Hancke C, Schoenmayr R, Loercher U (2009) Assessment of normal perisellar anatomy in 1.5 T T2-weighted MRI and comparison with the anatomical criteria defining cavernous sinus invasion of pituitary adenomas. Cent Eur Neurosurg 70:130–136CrossRef

18.

Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of cavernous space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33:610–617CrossRefPubMed

19.

Kumagai J, Sarkar K, Uhthoff HK, Okawara Y, Ooshima A (1994) Immunohistochemical distribution of type I, II and III collagens in the rabbit supraspinatus tendon insertion. J Anat 185:279–284PubMed

20.

Kursat E, Yilmazlar S, Aker S, Aksoy K, Oygucu H (2008) Comparison of lateral and superior walls of the pituitary fossa with clinical emphasis on pituitary adenoma extension: cadaveric-anatomic study. Neurosurg Rev 31:91–99CrossRefPubMed

21.

Liu W, Kunishio K, Matsumoto Y, Okada M, Nagao S (2005) Matrix metalloproteinase-2 expression correlates with cavernous sinus invasion in pituitary adenomas. J Clin Neurosci 12:791–794CrossRefPubMed

22.

Losa M, Mortini P, Barzaghi R, Ribotto P, Terreni MR, Marzoli SB, Pieralli S, Giovanelli M (2008) Early results of surgery in patients with non-functioning pituitary adenomas and analysis of the risk of tumor recurrence. J Neurosurg 108:525–532CrossRefPubMed

23.

Mastronardi L, Guidicci A, Spera C, Puzzilli F, Liberati F, Maira G (1999) Ki-67 labelling index and invasiveness among pituitary adenomas: analysis of 103 cases using the MIB-1 monoclonal antibody. J Clin Pathol 52:107–111CrossRefPubMed

24.

Paez-Pereda M, Kuchenbauer F, Arzt E, Stalla GK (2005) Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix. Braz J Med Biol Res 38:1487–1494CrossRefPubMed

25.

Pamir MN, Kilic T, Ozek MM, Ozduman K, Ture U (2006) Non-meningeal tumours of the cavernous sinus: a surgical analysis. J Clin Neurosci 13:626–635CrossRefPubMed

26.

Peker S, Kurtkaya-Yapicier O, Kilic T, Pamir MN (2005) Microsurgical anatomy of the lateral walls of the pituitary fossa. Acta Neurochir (Wien) 147:641–649CrossRef

27.

Qian ZR, Sano T, Yoshimoto K, Asa SL, Yamada S, Mizusawa N, Kudo E (2007) Tumor-specific downregulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas. Mod Pathol 20:1269–1277CrossRefPubMed

28.

Saeger W, Luedecke B, Luedecke DK (2008) Clinical tumor growth and comparison with proliferation markers in non-functioning (inactive) pituitary adenomas. Exp Clin Endocrinol Diabetes 116:80–85CrossRefPubMed

29.

Scheithauer BW, Kurtkaya-Yapicier O, Kovacs KT, Young WF Jr, Lloyd RV (2005) Pituitary carcinoma: a clinicopathological review. Neurosurgery 56:1066–1074PubMed

30.

Songtao Q, Yuntao L, Jun P, Chuanping H, Xiaofeng S (2009) Membraneous layers of the pituitary gland: histological anatomical study and related clinical issues. Neurosurgery 64(ONS Suppl 1):ons1–ons10CrossRef

31.

Thapar K, Kovacs KT, Scheithauer BW, Stefaneanu L, Horvath E, Pernicone PJ, Murray D, Laws ER Jr (1996) Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody. Neurosurgery 38:99–107CrossRefPubMed

32.

Trouillas J, Daniel L, Guigard M-P, Tong S, Gouvernet J, Jouanneau E, Jan M, Perrin G, Fischer G, Tabarin A, Rougon G, Figarella-Branger D (2003) Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion. J Neurosurg 98:1084–1093CrossRefPubMed

33.

Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA (2007) Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signalling in tumor cells. J Biol Chem 282:3929–3939CrossRefPubMed

34.

Yamada S, Ohyama K, Taguchi M, Takeshita A, Morita K, Takano K, Sano T (2007) A study of the correlation between morphological findings and biological activities in clinically non-functioning adenomas. Neurosurgery 61:580–584CrossRefPubMed

35.

Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC (2004) The medial wall of the cavernous sinus: microsurgical anatomy. Neurosurgery 55:179–190CrossRefPubMed

36.

Yilmazlar S, Kocaeli H, Aydiner F, Korfali E (2005) Medial portion of the cavernous sinus: quantitative analysis of the medial wall. Clin Anat 18:416–422CrossRefPubMed

37.

Yokoyama S, Hirano H, Moroki K, Goto M, Imamura S, Kuratsu J-I (2001) Are nonfuntioning adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49:857–863CrossRefPubMed

Titel: Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater
verfasst von: Ulrich J. Knappe
Thomas Fink
Annette Fisseler-Eckhoff
Robert Schoenmayr
Publikationsdatum: 01.02.2010
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 2/2010
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0497-9

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