Erschienen in:
12.08.2021 | Original Article
Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death
verfasst von:
Chunmei Feng, Chaoxu Zhang, Pengfei Wang, Xiaolong Wang, Jiabin You, Guohua Zhang, Hao Yu
Erschienen in:
Forensic Science, Medicine and Pathology
|
Ausgabe 4/2021
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Abstract
The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of FcεRIα and tryptase in lung tissues of the drug-induced anaphylactic death group (n = 30) and control group (who died due to sudden cardiac death, falling from a height, or traffic accidents, n = 30) was detected by immunohistochemistry and immunofluorescence staining. The difference in FcεRIα and tryptase expression in the lung tissue between the drug-induced anaphylactic death group and the control group was statistically significant (p < 0.05). The levels of FcεRIα and tryptase expression greatly increased in the lung tissue of the drug-induced anaphylactic death group, which may provide morphological evidence and a reference for the diagnosis of drug-induced anaphylactic death in forensic medicine.