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Acta Neuropathologica

Erschienen in:

01.08.2005 | Regular Paper

Expression of tubulin beta II in neuroepithelial tumors: reflection of architectural changes in the developing human brain

verfasst von: Yasuo Sugita, Yasuhiro Nakamura, Munehiko Yamamoto, Eriko Oda, Osamu Tokunaga, Minoru Shigemori

Erschienen in: Acta Neuropathologica | Ausgabe 2/2005

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Abstract

Tubulin beta II (Tub-II) is widely distributed in the developing neuronal axons and dendrites. Recent studies have demonstrated that Tub-II is also important in the early development of the human brain, and Tub-II represents a marker for progenitor and neural stem cells. To elucidate the correlation between the developing brain and neuroepithelial tumors (NETs), the present study assessed Tub-II expression by NETs and normal brain tissue using immunohistochemical and immunoblot analyses. In the gliomas, decreased numbers and staining intensities of Tub-II-positive cells tended to be associated with increased differentiation. Conversely, neuronal neoplasms displayed high percentages and strong staining intensities among the Tub-II-positive cells, irrespective of differentiation. In neuronal neoplasms and neoplasms with neuronal differentiation, Tub-II staining was far more intense and more homogeneous than Tub-II staining in gliomas. These results indicate that the expression of Tub-II in NETs may reflect architectural changes in the developing brain and may support the hypothesis that neuroepithelial tumors originate from glioneuronal progenitor cells capable of generating astrocytic, and neuronal cell types.

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Titel: Expression of tubulin beta II in neuroepithelial tumors: reflection of architectural changes in the developing human brain
verfasst von: Yasuo Sugita
Yasuhiro Nakamura
Munehiko Yamamoto
Eriko Oda
Osamu Tokunaga
Minoru Shigemori
Publikationsdatum: 01.08.2005
Verlag: Springer-Verlag
Erschienen in: Acta Neuropathologica / Ausgabe 2/2005
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-005-1022-8

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