Erschienen in:
01.01.2012 | Case Report
Extraskeletal Osteosarcoma of Subcutaneous Soft Tissue with Lymph Node and Skin Metastasis: A Case Report with Fluorescence in Situ Hybridization Analysis
verfasst von:
Dionysios J. Papachristou, Mark Goodman, Kathleen Cieply, Uma N. M. Rao
Erschienen in:
Pathology & Oncology Research
|
Ausgabe 1/2012
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Excerpt
Osteosarcomas represent the 35% of all malignant bone neoplasms and affect mainly children and young adults [
1]. Their principal histopathologic feature is the production of osteoid or bony matrix by the tumor cells [
2]. Extraskeletal osteosarcoma (EOS) arises from mesenchymal cells of soft tissues and accounts for approximately 2–4% of all osteosarcomas [
3]. Unlike its skeletal counterpart, EOS occurs primarily in adulthood (5th to 7th decades of life). The thigh, buttock, upper extremity and retroperitoneum are the most common anatomic locations [
3‐
5]. EOS has a very poor prognosis, and 75% of the patients die within 5 years of the initial diagnosis. In 60% of the cases they develop metastases, mainly to the lungs and bones [
4]. …