Skip to main content
Erschienen in: Endocrine 3/2016

26.10.2015 | Review

False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers

verfasst von: Vincenzo Triggiani, Vito Angelo Giagulli, Michele Iovino, Giovanni De Pergola, Brunella Licchelli, Antonio Varraso, Franca Dicembrino, Guido Valle, Edoardo Guastamacchia

Erschienen in: Endocrine | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

131Iodine is used both to ablate any residual thyroid tissue or metastatic disease and to obtain whole-body diagnostic images after total thyroidectomy for differentiated thyroid cancer (DTC). Even though whole-body scan is highly accurate in showing thyroid residues as well as metastases of DTC, false positive results can be found, possibly leading to diagnostic errors and unnecessary treatments. This paper reviews the physiological and pathological processes involved as well as the strategy to recognize and rule out false positive radioiodine images.
Literatur
1.
Zurück zum Zitat V. Triggiani, E. Tafaro, V.A. Giagulli, C. Sabbà, F. Resta, B. Licchelli, E. Guastamacchia, Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr. Metab. Immune Disord. Drug Targets 9(3), 277–294 (2009)PubMedCrossRef V. Triggiani, E. Tafaro, V.A. Giagulli, C. Sabbà, F. Resta, B. Licchelli, E. Guastamacchia, Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr. Metab. Immune Disord. Drug Targets 9(3), 277–294 (2009)PubMedCrossRef
2.
Zurück zum Zitat G. Noussios, P. Anagnostis, D.G. Goulis, D. Lappas, K. Natsis, Ectopic thyroid tissue: anatomical, clinical, and surgical implications of a rare entity. Eur. J. Endocrinol. 165(3), 375–382 (2011). doi:10.1530/EJE-11-0461 PubMedCrossRef G. Noussios, P. Anagnostis, D.G. Goulis, D. Lappas, K. Natsis, Ectopic thyroid tissue: anatomical, clinical, and surgical implications of a rare entity. Eur. J. Endocrinol. 165(3), 375–382 (2011). doi:10.​1530/​EJE-11-0461 PubMedCrossRef
3.
Zurück zum Zitat V. Triggiani, V.A. Giagulli, A. Tafaro, F. Resta, C. Sabbà, B. Licchelli, E. Guastamacchia, Ectopic thyroid gland: description of a case and review of the literature. Endocr. Metab. Immune Disord. Drug Targets 13(3), 275–281 (2013)PubMedCrossRef V. Triggiani, V.A. Giagulli, A. Tafaro, F. Resta, C. Sabbà, B. Licchelli, E. Guastamacchia, Ectopic thyroid gland: description of a case and review of the literature. Endocr. Metab. Immune Disord. Drug Targets 13(3), 275–281 (2013)PubMedCrossRef
4.
Zurück zum Zitat J.P. van Wijk, H.S. Broekhuizen-de Gast, A.J. Smits, M.E. Schipper, P.M. Zelissen, Scintigraphic detection of benign ovarian teratoma after total thyroidectomy and radioactive iodine for differentiated thyroid cancer. J. Clin. Endocrinol. Metab. 97(4), 1094–1095 (2012). doi:10.1210/jc.2011-2433 PubMedCrossRef J.P. van Wijk, H.S. Broekhuizen-de Gast, A.J. Smits, M.E. Schipper, P.M. Zelissen, Scintigraphic detection of benign ovarian teratoma after total thyroidectomy and radioactive iodine for differentiated thyroid cancer. J. Clin. Endocrinol. Metab. 97(4), 1094–1095 (2012). doi:10.​1210/​jc.​2011-2433 PubMedCrossRef
5.
Zurück zum Zitat M. Salvatori, V. Rufini, M.S. Daidone, F.M. Danza, A.L. Valentini, F. Negro, G. Restifo, L. Troncone, Occasional detection of “struma ovarii” in a patient with thyroid carcinoma. Radiol. Med. 81(5), 744–747 (1991)PubMed M. Salvatori, V. Rufini, M.S. Daidone, F.M. Danza, A.L. Valentini, F. Negro, G. Restifo, L. Troncone, Occasional detection of “struma ovarii” in a patient with thyroid carcinoma. Radiol. Med. 81(5), 744–747 (1991)PubMed
6.
Zurück zum Zitat S.T. Zwas, Z. Heyman, L.M. Lieberman, 131-I ovarian uptake in a whole body scan for thyroid carcinoma. Semin. Nucl. Med. 19(4), 340–342 (1989)PubMedCrossRef S.T. Zwas, Z. Heyman, L.M. Lieberman, 131-I ovarian uptake in a whole body scan for thyroid carcinoma. Semin. Nucl. Med. 19(4), 340–342 (1989)PubMedCrossRef
7.
Zurück zum Zitat S. Rudoni, M. Toubeau, G. Vaillant, L. Arnould, B. Vergès, J.M. Brun, F. Brunotte, Dermoid cyst of the ovary. False positive diagnosis in iodine 131 scintigraphy of differentiated thyroid cancers. Presse Med. 27(27), 1379–1381 (1998)PubMed S. Rudoni, M. Toubeau, G. Vaillant, L. Arnould, B. Vergès, J.M. Brun, F. Brunotte, Dermoid cyst of the ovary. False positive diagnosis in iodine 131 scintigraphy of differentiated thyroid cancers. Presse Med. 27(27), 1379–1381 (1998)PubMed
8.
Zurück zum Zitat M. Mebarki, A. Menemani, A. Medjahedi, F. Boualou, A. Slama, S. Ouguirti, F.Z. Kherbouche, N. Berber, Radioiodine accumulation in a giant ovarian cystadenofibroma detected incidentally by 131-I whole body scans. Case Rep. Radiol. 2012, 295617 (2012). doi:10.1155/2012/295617 PubMedPubMedCentral M. Mebarki, A. Menemani, A. Medjahedi, F. Boualou, A. Slama, S. Ouguirti, F.Z. Kherbouche, N. Berber, Radioiodine accumulation in a giant ovarian cystadenofibroma detected incidentally by 131-I whole body scans. Case Rep. Radiol. 2012, 295617 (2012). doi:10.​1155/​2012/​295617 PubMedPubMedCentral
9.
Zurück zum Zitat S.M. Bakheet, M.M. Hammami, Patterns of radioiodine uptake by the lactating breast. Eur. J. Nucl. Med. 21(7), 604–608 (1994)PubMedCrossRef S.M. Bakheet, M.M. Hammami, Patterns of radioiodine uptake by the lactating breast. Eur. J. Nucl. Med. 21(7), 604–608 (1994)PubMedCrossRef
10.
Zurück zum Zitat C. Spitzweg, W. Joba, W. Eisenmenger, A.E. Heufelder, Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complimentary deoxyribonucleic acids from salivary gland, mammary gland and gastric mucosa. J. Clin. Endocrinol. Metab. 83(5), 1746–1751 (1998)PubMedCrossRef C. Spitzweg, W. Joba, W. Eisenmenger, A.E. Heufelder, Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complimentary deoxyribonucleic acids from salivary gland, mammary gland and gastric mucosa. J. Clin. Endocrinol. Metab. 83(5), 1746–1751 (1998)PubMedCrossRef
11.
Zurück zum Zitat I.S. Kolla, N.P. Alazraki, N.B. Watts, Sialadenitis mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 14(8), 564–566 (1989)PubMedCrossRef I.S. Kolla, N.P. Alazraki, N.B. Watts, Sialadenitis mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 14(8), 564–566 (1989)PubMedCrossRef
12.
Zurück zum Zitat S.M. Bakheet, M.M. Hammami, False-positive radioiodine whole-body scan in thyroid cancer patients due to unrelated pathology. Clin. Nucl. Med. 19(4), 325–329 (1994)PubMedCrossRef S.M. Bakheet, M.M. Hammami, False-positive radioiodine whole-body scan in thyroid cancer patients due to unrelated pathology. Clin. Nucl. Med. 19(4), 325–329 (1994)PubMedCrossRef
13.
Zurück zum Zitat S. Kim, G.H. Park, S.N. Yoon, K. Hwang, A false-positive I-131 whole-body scan in chronic parotitis: a case report. Clin. Nucl. Med. 26(6), 536–537 (2001)PubMedCrossRef S. Kim, G.H. Park, S.N. Yoon, K. Hwang, A false-positive I-131 whole-body scan in chronic parotitis: a case report. Clin. Nucl. Med. 26(6), 536–537 (2001)PubMedCrossRef
14.
Zurück zum Zitat P. Matheja, H. Lerch, K.W. Schmid, T. Kuwert, O. Schober, Frontal sinus mucocele mimicking a metastasis of papillary thyroid carcinoma. J. Nucl. Med. 38(7), 1022–1024 (1997)PubMed P. Matheja, H. Lerch, K.W. Schmid, T. Kuwert, O. Schober, Frontal sinus mucocele mimicking a metastasis of papillary thyroid carcinoma. J. Nucl. Med. 38(7), 1022–1024 (1997)PubMed
15.
Zurück zum Zitat M. Schmidt, M. Dietlein, U. Schröder, H. Schicha, False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin. Nucl. Med. 31(11), 716–717 (2006)PubMedCrossRef M. Schmidt, M. Dietlein, U. Schröder, H. Schicha, False-positive uptake of I-131 in a laryngocele mimicking thyroid remnant after thyroidectomy for papillary thyroid carcinoma. Clin. Nucl. Med. 31(11), 716–717 (2006)PubMedCrossRef
16.
Zurück zum Zitat L.L. Willis, R.J. Cowan, Mediastinal uptake of I131 in a hiatal hernia mimicking recurrence of papillary thyroid carcinoma. Clin. Nucl. Med. 18(11), 961–963 (1993)PubMedCrossRef L.L. Willis, R.J. Cowan, Mediastinal uptake of I131 in a hiatal hernia mimicking recurrence of papillary thyroid carcinoma. Clin. Nucl. Med. 18(11), 961–963 (1993)PubMedCrossRef
17.
Zurück zum Zitat J.A. Schneider, C.R. Divgi, A.M. Scott, H.A. Macapinlac, M. Sonenberg, S.J. Goldsmith, S.M. Larson, Hiatal hernia on whole-body radioiodine survey mimicking metastatic thyroid cancer. Clin. Nucl. Med. 18(9), 751–753 (1993)PubMedCrossRef J.A. Schneider, C.R. Divgi, A.M. Scott, H.A. Macapinlac, M. Sonenberg, S.J. Goldsmith, S.M. Larson, Hiatal hernia on whole-body radioiodine survey mimicking metastatic thyroid cancer. Clin. Nucl. Med. 18(9), 751–753 (1993)PubMedCrossRef
18.
Zurück zum Zitat Y. Ho, R. Hicks, Hiatus hernia: a potential cause of false-positive iodine-131 scan in thyroid carcinoma. Clin. Nucl. Med. 23(9), 621–622 (1998)PubMedCrossRef Y. Ho, R. Hicks, Hiatus hernia: a potential cause of false-positive iodine-131 scan in thyroid carcinoma. Clin. Nucl. Med. 23(9), 621–622 (1998)PubMedCrossRef
19.
Zurück zum Zitat R.H. Caplan, G.A. Gundersen, R.M. Abellera, W.A. Kisken, Uptake of iodine-131 by a Meckel’s diverticulum mimicking metastatic thyroid cancer. Clin. Nucl. Med. 12(9), 760–762 (1987)PubMedCrossRef R.H. Caplan, G.A. Gundersen, R.M. Abellera, W.A. Kisken, Uptake of iodine-131 by a Meckel’s diverticulum mimicking metastatic thyroid cancer. Clin. Nucl. Med. 12(9), 760–762 (1987)PubMedCrossRef
20.
Zurück zum Zitat T.H. Berquist, N.G. Nolan, D.H. Stephens, H.C. Carlson, Radioisotope scintigraphy in diagnosis of Barrett’s esophagus. Am J Roentgenol Radium Ther Nucl Med. 123(2), 401–411 (1975)PubMedCrossRef T.H. Berquist, N.G. Nolan, D.H. Stephens, H.C. Carlson, Radioisotope scintigraphy in diagnosis of Barrett’s esophagus. Am J Roentgenol Radium Ther Nucl Med. 123(2), 401–411 (1975)PubMedCrossRef
22.
Zurück zum Zitat S.Y. Wu, J. Kollin, E. Coodley, T. Lockyer, K.P. Lyons, E. Moran, L.N. Parker, A.C. Yu, I-131 total-body scan: localization of disseminated gastric adenocarcinoma. Case report and survey of the literature. J. Nucl. Med. 25(11), 1204–1209 (1984)PubMed S.Y. Wu, J. Kollin, E. Coodley, T. Lockyer, K.P. Lyons, E. Moran, L.N. Parker, A.C. Yu, I-131 total-body scan: localization of disseminated gastric adenocarcinoma. Case report and survey of the literature. J. Nucl. Med. 25(11), 1204–1209 (1984)PubMed
23.
Zurück zum Zitat R.W. Burt, Accumulation of I123 in a Warthin’s tumour. Clin. Nucl. Med. 3(4), 155–156 (1978)PubMedCrossRef R.W. Burt, Accumulation of I123 in a Warthin’s tumour. Clin. Nucl. Med. 3(4), 155–156 (1978)PubMedCrossRef
24.
Zurück zum Zitat M. Lakshmanan, J.C. Reynolds, S. Del Vecchio, M.J. Merino, J.A. Norton, J. Robbins, Pelvic radioiodine uptake in a rectal wall teratoma after thyroidectomy for papillary carcinoma. J. Nucl. Med. 33(10), 1848–1850 (1992)PubMed M. Lakshmanan, J.C. Reynolds, S. Del Vecchio, M.J. Merino, J.A. Norton, J. Robbins, Pelvic radioiodine uptake in a rectal wall teratoma after thyroidectomy for papillary carcinoma. J. Nucl. Med. 33(10), 1848–1850 (1992)PubMed
25.
Zurück zum Zitat T. Allen, P. Wiest, S. Vela, M. Hartshorne, L.A. Crooks, I-131 uptake in the breast for thyroid cancer surveillance with biopsy-proven benign tissue. Clin. Nucl. Med. 23(9), 585–587 (1998)PubMedCrossRef T. Allen, P. Wiest, S. Vela, M. Hartshorne, L.A. Crooks, I-131 uptake in the breast for thyroid cancer surveillance with biopsy-proven benign tissue. Clin. Nucl. Med. 23(9), 585–587 (1998)PubMedCrossRef
26.
Zurück zum Zitat U.H. Tazebay, I.L. Wapnir, O. Levy, O. Dohan, L.S. Zuckier, Q.H. Zhao, H.F. Deng, P.S. Amenta, S. Fineberg, R.G. Pestell, N. Carrasco, The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat. Med. 6(8), 871–878 (2000)PubMedCrossRef U.H. Tazebay, I.L. Wapnir, O. Levy, O. Dohan, L.S. Zuckier, Q.H. Zhao, H.F. Deng, P.S. Amenta, S. Fineberg, R.G. Pestell, N. Carrasco, The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat. Med. 6(8), 871–878 (2000)PubMedCrossRef
27.
Zurück zum Zitat M. Fernandez-Ulloa, H.R. Maxon, S. Mehta, L.J. Sholiton, Iodine 131 uptake by primary lung adenocarcinoma, misinterpretation of 131I scan. JAMA 236(7), 857–858 (1976)PubMedCrossRef M. Fernandez-Ulloa, H.R. Maxon, S. Mehta, L.J. Sholiton, Iodine 131 uptake by primary lung adenocarcinoma, misinterpretation of 131I scan. JAMA 236(7), 857–858 (1976)PubMedCrossRef
28.
Zurück zum Zitat B.G. Haubold-Reuter, U. Landolt, G.K. von Schulthess, Bronchogenic carcinoma mimicking metastatic thyroid carcinoma. J. Nucl. Med. 34(5), 809–811 (1993)PubMed B.G. Haubold-Reuter, U. Landolt, G.K. von Schulthess, Bronchogenic carcinoma mimicking metastatic thyroid carcinoma. J. Nucl. Med. 34(5), 809–811 (1993)PubMed
29.
Zurück zum Zitat M. Lejeune, C. Héron, F. Tenenbaum, P.O. Sarfati, A. Louvel, J.P. Luton, B. Richard, Iodine 131 uptake by a bronchogenic cyst in a patient with differentiated carcinoma of the thyroid gland. Presse Med. 29(24), 1345–1347 (2000)PubMed M. Lejeune, C. Héron, F. Tenenbaum, P.O. Sarfati, A. Louvel, J.P. Luton, B. Richard, Iodine 131 uptake by a bronchogenic cyst in a patient with differentiated carcinoma of the thyroid gland. Presse Med. 29(24), 1345–1347 (2000)PubMed
31.
Zurück zum Zitat W.T. Pochis, A.Z. Krasnow, A.T. Isitman, J.M. Cerletty, K.M. Kir, R.S. Hellman, B.D. Collier, The radioactive handkerchief sign. A contamination artifact in I-131 imaging for metastatic thyroid carcinoma. Clin. Nucl. Med. 15(7), 491–494 (1990)PubMedCrossRef W.T. Pochis, A.Z. Krasnow, A.T. Isitman, J.M. Cerletty, K.M. Kir, R.S. Hellman, B.D. Collier, The radioactive handkerchief sign. A contamination artifact in I-131 imaging for metastatic thyroid carcinoma. Clin. Nucl. Med. 15(7), 491–494 (1990)PubMedCrossRef
32.
Zurück zum Zitat H.M. Park, R.D. Tarver, D.S. Schauwecker, R. Burt, Spurious thyroid cancer metastasis: saliva contamination artifact in high dose iodine-131 metastases survey. J. Nucl. Med. 27(5), 634–636 (1986)PubMed H.M. Park, R.D. Tarver, D.S. Schauwecker, R. Burt, Spurious thyroid cancer metastasis: saliva contamination artifact in high dose iodine-131 metastases survey. J. Nucl. Med. 27(5), 634–636 (1986)PubMed
33.
Zurück zum Zitat I. Boxen, Z.M. Zhang, Nasal secretion of iodine-131. Clin. Nucl. Med. 15(9), 610–611 (1990)PubMedCrossRef I. Boxen, Z.M. Zhang, Nasal secretion of iodine-131. Clin. Nucl. Med. 15(9), 610–611 (1990)PubMedCrossRef
34.
Zurück zum Zitat J. Schlosser, M. Paliou, R. Bravo-Vera, A. Sheikh, A. Gouller, False positive uptake in post-treatment iodine-131 whole-body scans secondary to contamination. Thyroid 17(1), 81–82 (2007)PubMedCrossRef J. Schlosser, M. Paliou, R. Bravo-Vera, A. Sheikh, A. Gouller, False positive uptake in post-treatment iodine-131 whole-body scans secondary to contamination. Thyroid 17(1), 81–82 (2007)PubMedCrossRef
35.
Zurück zum Zitat W.T. Joyce, R.J. Cowan, A potential false-positive posttherapy radioiodine scan secondary to I-131 excretion in perspiration. Clin. Nucl. Med. 20(4), 368–369 (1995)PubMedCrossRef W.T. Joyce, R.J. Cowan, A potential false-positive posttherapy radioiodine scan secondary to I-131 excretion in perspiration. Clin. Nucl. Med. 20(4), 368–369 (1995)PubMedCrossRef
36.
Zurück zum Zitat E.J. Camponovo, P.F. Goyer, E.D. Silverman, A.M. Kistler, W.M. Yudt, Axillary iodine-131 accumulation due to perspiration. Clin. Nucl. Med. 14(10), 762–763 (1989)PubMedCrossRef E.J. Camponovo, P.F. Goyer, E.D. Silverman, A.M. Kistler, W.M. Yudt, Axillary iodine-131 accumulation due to perspiration. Clin. Nucl. Med. 14(10), 762–763 (1989)PubMedCrossRef
37.
Zurück zum Zitat S.R. Zakavi, V.D. Kakhki, Exercise-induced radio-iodine accumulation in scalp and hair during admission of 131I therapy for thyroid cancer. Thyroid 16(11), 1185–1186 (2006)PubMedCrossRef S.R. Zakavi, V.D. Kakhki, Exercise-induced radio-iodine accumulation in scalp and hair during admission of 131I therapy for thyroid cancer. Thyroid 16(11), 1185–1186 (2006)PubMedCrossRef
38.
Zurück zum Zitat M. Ozguven, S. Ilgan, N. Arslan, A.O. Karacalioglu, D. Yuksel, S. Dundar, Unusual patterns of I-131 contamination. Ann. Nucl. Med. 18(3), 271–274 (2004)PubMedCrossRef M. Ozguven, S. Ilgan, N. Arslan, A.O. Karacalioglu, D. Yuksel, S. Dundar, Unusual patterns of I-131 contamination. Ann. Nucl. Med. 18(3), 271–274 (2004)PubMedCrossRef
39.
Zurück zum Zitat L.S. Gritters, J. Wissing, M.D. Gross, B. Shapiro, Extensive salivary contamination due to concurrent use of chewing tobacco during I-131 radioablative therapy. Clin. Nucl. Med. 18(2), 115–117 (1993)PubMedCrossRef L.S. Gritters, J. Wissing, M.D. Gross, B. Shapiro, Extensive salivary contamination due to concurrent use of chewing tobacco during I-131 radioablative therapy. Clin. Nucl. Med. 18(2), 115–117 (1993)PubMedCrossRef
40.
Zurück zum Zitat C.J.A. Vallejo, B.M.L. Mena, M.M.A. Gálvez, R.J.M. Latre, Tracheostomy cannula as a cause of false positive result on the whole-body scan with (131)I in the follow-up of differentiated thyroid cancer. Rev. Esp. Med. Nucl. 30(6), 384–385 (2011). doi:10.1016/j.remn.2011.03.011 CrossRef C.J.A. Vallejo, B.M.L. Mena, M.M.A. Gálvez, R.J.M. Latre, Tracheostomy cannula as a cause of false positive result on the whole-body scan with (131)I in the follow-up of differentiated thyroid cancer. Rev. Esp. Med. Nucl. 30(6), 384–385 (2011). doi:10.​1016/​j.​remn.​2011.​03.​011 CrossRef
41.
Zurück zum Zitat K.B. Ain, W.J. Shih, False-positive I-131 uptake at a tracheostomy site. Discernment with Tl-201 imaging. Clin. Nucl. Med. 19(7), 619–621 (1994)PubMedCrossRef K.B. Ain, W.J. Shih, False-positive I-131 uptake at a tracheostomy site. Discernment with Tl-201 imaging. Clin. Nucl. Med. 19(7), 619–621 (1994)PubMedCrossRef
42.
Zurück zum Zitat G.A. Kirk, E.E. Schulz, Post-laryngectomy localization of I-131 at tracheostomy site on a total body scan. Clin. Nucl. Med. 9(7), 409–411 (1984)PubMedCrossRef G.A. Kirk, E.E. Schulz, Post-laryngectomy localization of I-131 at tracheostomy site on a total body scan. Clin. Nucl. Med. 9(7), 409–411 (1984)PubMedCrossRef
43.
Zurück zum Zitat S. Karyagar, E. Uyanik, S.S. Karyagar, R. Uslu, False-positive orbital uptake on (131)I scintigraphy due to ocular prothesis. Hell. J. Nucl. Med. 11(3), 193 (2008)PubMed S. Karyagar, E. Uyanik, S.S. Karyagar, R. Uslu, False-positive orbital uptake on (131)I scintigraphy due to ocular prothesis. Hell. J. Nucl. Med. 11(3), 193 (2008)PubMed
44.
Zurück zum Zitat S. Bakheet, M.M. Hammami, Spurious lung metastases on radioiodine thyroid and whole body imaging. Clin. Nucl. Med. 18(4), 307–312 (1993)PubMedCrossRef S. Bakheet, M.M. Hammami, Spurious lung metastases on radioiodine thyroid and whole body imaging. Clin. Nucl. Med. 18(4), 307–312 (1993)PubMedCrossRef
45.
Zurück zum Zitat J.R. Oh, B.C. Ahn, False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am. J. Nucl. Med. Mol. Imaging 2(3), 362–385 (2012)PubMedPubMedCentral J.R. Oh, B.C. Ahn, False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer. Am. J. Nucl. Med. Mol. Imaging 2(3), 362–385 (2012)PubMedPubMedCentral
46.
Zurück zum Zitat S.M. Bakheet, M.M. Hammami, J. Powe, False positive radioiodine uptake in the abdomen and the pelvis: radioiodine retention in the kidneys and review of literature. Clin. Nucl. Med. 21(12), 932–937 (1996)PubMedCrossRef S.M. Bakheet, M.M. Hammami, J. Powe, False positive radioiodine uptake in the abdomen and the pelvis: radioiodine retention in the kidneys and review of literature. Clin. Nucl. Med. 21(12), 932–937 (1996)PubMedCrossRef
47.
Zurück zum Zitat M.B. Brachman, B.J. Rothman, L. Ramanna, D.E. Tanasescu, H. Adelberg, A.D. Waxman, False-positive iodine-131 body scan caused by a large renal cyst. Clin. Nucl. Med. 13(6), 416–418 (1988)PubMedCrossRef M.B. Brachman, B.J. Rothman, L. Ramanna, D.E. Tanasescu, H. Adelberg, A.D. Waxman, False-positive iodine-131 body scan caused by a large renal cyst. Clin. Nucl. Med. 13(6), 416–418 (1988)PubMedCrossRef
48.
Zurück zum Zitat O. Kraft, P. Sirucek, L. Mrhac, M. Havel, I-131 false positive uptake in a huge parapelvic renal cyst. Nucl. Med. Rev. Cent. East Eur. 14(1), 36–37 (2011)PubMedCrossRef O. Kraft, P. Sirucek, L. Mrhac, M. Havel, I-131 false positive uptake in a huge parapelvic renal cyst. Nucl. Med. Rev. Cent. East Eur. 14(1), 36–37 (2011)PubMedCrossRef
49.
Zurück zum Zitat D. Giuffrida, M.C. Fornito, G. Pellegriti, C. Regalbuto, G. Vigneri, False positive 131I total body scan due to bilateral polycystic renal disease. J. Endocrinol. Invest. 20(6), 342–344 (1997)PubMedCrossRef D. Giuffrida, M.C. Fornito, G. Pellegriti, C. Regalbuto, G. Vigneri, False positive 131I total body scan due to bilateral polycystic renal disease. J. Endocrinol. Invest. 20(6), 342–344 (1997)PubMedCrossRef
50.
Zurück zum Zitat H. Boulahdour, M. Meignan, D. Mellière, F. Braga, P. Galle, False-positive I-131 scan induced by Zenker’s diverticulum. Clin. Nucl. Med. 17(3), 243–244 (1992)PubMedCrossRef H. Boulahdour, M. Meignan, D. Mellière, F. Braga, P. Galle, False-positive I-131 scan induced by Zenker’s diverticulum. Clin. Nucl. Med. 17(3), 243–244 (1992)PubMedCrossRef
51.
Zurück zum Zitat K. Rashid, W. Johns, K. Chasse, M. Walker, S.M. Gupta, Esophageal diverticulum presenting as metastatic thyroid mass on iodine-131 scintigraphy. Clin. Nucl. Med. 31(7), 405–408 (2006)PubMedCrossRef K. Rashid, W. Johns, K. Chasse, M. Walker, S.M. Gupta, Esophageal diverticulum presenting as metastatic thyroid mass on iodine-131 scintigraphy. Clin. Nucl. Med. 31(7), 405–408 (2006)PubMedCrossRef
52.
Zurück zum Zitat A. Ozdemir, F. Güngör, S. Ozuğur, M. Cubuk, A. Boz, B. Karayalçin, Abnormal iodine-131 uptake in the mediastinum caused by achalasia. Clin. Nucl. Med. 23(10), 706–707 (1998)PubMedCrossRef A. Ozdemir, F. Güngör, S. Ozuğur, M. Cubuk, A. Boz, B. Karayalçin, Abnormal iodine-131 uptake in the mediastinum caused by achalasia. Clin. Nucl. Med. 23(10), 706–707 (1998)PubMedCrossRef
53.
Zurück zum Zitat B.D. Nguyen, M.C. Roarke, Epiphrenic diverticulum: potential pitfall in thyroid cancer iodine-131 scintigraphy. Clin. Nucl. Med. 30(9), 631–632 (2005)PubMedCrossRef B.D. Nguyen, M.C. Roarke, Epiphrenic diverticulum: potential pitfall in thyroid cancer iodine-131 scintigraphy. Clin. Nucl. Med. 30(9), 631–632 (2005)PubMedCrossRef
54.
Zurück zum Zitat C. Ceccarelli, F. Pacini, F. Lippi, A. Pinchera, An unusual case of a false-positive iodine-131 whole body scan in a patient with papillary thyroid cancer. Clin. Nucl. Med. 13(3), 192–193 (1988)PubMedCrossRef C. Ceccarelli, F. Pacini, F. Lippi, A. Pinchera, An unusual case of a false-positive iodine-131 whole body scan in a patient with papillary thyroid cancer. Clin. Nucl. Med. 13(3), 192–193 (1988)PubMedCrossRef
55.
Zurück zum Zitat D.M. Schuster, N. Alazraki, Esophageal scarring causing false-positive uptake on I-131 whole-body imaging. Clin. Nucl. Med. 23(5), 334 (1998)PubMedCrossRef D.M. Schuster, N. Alazraki, Esophageal scarring causing false-positive uptake on I-131 whole-body imaging. Clin. Nucl. Med. 23(5), 334 (1998)PubMedCrossRef
56.
Zurück zum Zitat S. Bakheet, M.M. Hammami, False-positive thyroid cancer metastasis on whole-body radioiodine scanning due to retained radioactivity in the oesophagus. Eur. J. Nucl. Med. 20(5), 415–419 (1993)PubMedCrossRef S. Bakheet, M.M. Hammami, False-positive thyroid cancer metastasis on whole-body radioiodine scanning due to retained radioactivity in the oesophagus. Eur. J. Nucl. Med. 20(5), 415–419 (1993)PubMedCrossRef
57.
Zurück zum Zitat M.S. Kipper, L.D. Krohn, Increased submandibular gland uptake on thyroid scintigraphy due to Wharton’s duct stone. Clin. Nucl. Med. 21(11), 881–882 (1996)PubMedCrossRef M.S. Kipper, L.D. Krohn, Increased submandibular gland uptake on thyroid scintigraphy due to Wharton’s duct stone. Clin. Nucl. Med. 21(11), 881–882 (1996)PubMedCrossRef
58.
Zurück zum Zitat H. Wolff, D.J. Breda, N. Da Silva, A.A. Hartmann, False-positive I-131 deposition in a parotid gland duct ectasia. Clin. Nucl. Med. 23(4), 257–259 (1998)PubMedCrossRef H. Wolff, D.J. Breda, N. Da Silva, A.A. Hartmann, False-positive I-131 deposition in a parotid gland duct ectasia. Clin. Nucl. Med. 23(4), 257–259 (1998)PubMedCrossRef
59.
Zurück zum Zitat D.L. You, K.Y. Tzen, J.F. Chen, P.F. Kao, M.F. Tsai, False-positive whole-body iodine-131 scan due to intrahepatic duct dilatation. J. Nucl. Med. 38(12), 1977–1979 (1997)PubMed D.L. You, K.Y. Tzen, J.F. Chen, P.F. Kao, M.F. Tsai, False-positive whole-body iodine-131 scan due to intrahepatic duct dilatation. J. Nucl. Med. 38(12), 1977–1979 (1997)PubMed
60.
Zurück zum Zitat M. Carlisle, A. Cortés, I.R. McDougall, Uptake of I-131 in the biliary tract: a potential cause of a false-positive result of scintiscan. Clin. Nucl. Med. 23(8), 524–527 (1998)PubMedCrossRef M. Carlisle, A. Cortés, I.R. McDougall, Uptake of I-131 in the biliary tract: a potential cause of a false-positive result of scintiscan. Clin. Nucl. Med. 23(8), 524–527 (1998)PubMedCrossRef
61.
Zurück zum Zitat C. Okuyama, Y. Ushijima, M. Kikkawa, T. Yamagami, T. Nakamura, K. Kobayashi, T. Hirota, T. Nishimura, False-positive I-131 accumulation in a liver cyst in a patient with thyroid carcinoma. Clin. Nucl. Med. 26(3), 198–201 (2001)PubMedCrossRef C. Okuyama, Y. Ushijima, M. Kikkawa, T. Yamagami, T. Nakamura, K. Kobayashi, T. Hirota, T. Nishimura, False-positive I-131 accumulation in a liver cyst in a patient with thyroid carcinoma. Clin. Nucl. Med. 26(3), 198–201 (2001)PubMedCrossRef
62.
Zurück zum Zitat A. Serafini, G. Sfakianakis, M. Georgiou, J. Morris, Breast cyst simulating metastases on iodine-131 imaging in thyroid carcinoma. J. Nucl. Med. 39(11), 1910–1912 (1998)PubMed A. Serafini, G. Sfakianakis, M. Georgiou, J. Morris, Breast cyst simulating metastases on iodine-131 imaging in thyroid carcinoma. J. Nucl. Med. 39(11), 1910–1912 (1998)PubMed
63.
Zurück zum Zitat M.M. Maslack, C.A. Wilson, Iodine-131 accumulation in a pericardial effusion. J. Nucl. Med. 28(1), 133 (1987)PubMed M.M. Maslack, C.A. Wilson, Iodine-131 accumulation in a pericardial effusion. J. Nucl. Med. 28(1), 133 (1987)PubMed
64.
Zurück zum Zitat C. Francese, M. Schlumberger, J.P. Travagli, P. Vera, B. Caillou, C. Parmentier, Iodine 131 uptake in a pleuropericardial cyst: case report of a false-positive radioiodine total body scan result in a patient with a thyroid cancer. Eur. J. Nucl. Med. 18(9), 779–780 (1991)PubMedCrossRef C. Francese, M. Schlumberger, J.P. Travagli, P. Vera, B. Caillou, C. Parmentier, Iodine 131 uptake in a pleuropericardial cyst: case report of a false-positive radioiodine total body scan result in a patient with a thyroid cancer. Eur. J. Nucl. Med. 18(9), 779–780 (1991)PubMedCrossRef
65.
Zurück zum Zitat O. Geatti, B. Shapiro, P.G. Orsolon, R. Mirolo, A. Di Donna, An unusual false-positive scan in a patient with pericardial effusion. Clin. Nucl. Med. 19(8), 678–682 (1994)PubMedCrossRef O. Geatti, B. Shapiro, P.G. Orsolon, R. Mirolo, A. Di Donna, An unusual false-positive scan in a patient with pericardial effusion. Clin. Nucl. Med. 19(8), 678–682 (1994)PubMedCrossRef
66.
Zurück zum Zitat A.D. López, S.L. García, S.A. Rivas, M.J. Alonso, B.I. Hervás, N.A. Mateo, Pericardial effusion as a possible cause of false positives in I-131 radionuclide scans. Rev. Esp. Med. Nucl. 17(3), 158–161 (1998) A.D. López, S.L. García, S.A. Rivas, M.J. Alonso, B.I. Hervás, N.A. Mateo, Pericardial effusion as a possible cause of false positives in I-131 radionuclide scans. Rev. Esp. Med. Nucl. 17(3), 158–161 (1998)
67.
Zurück zum Zitat D. Giuffrida, M.R. Garofalo, G. Cacciaguerra, V. Freni, A. Ippolito, C. Regalbuto, M.G. Santonocito, A. Belfiore, False positive 131I total body scan due to an ectasia of the common carotidis. J. Endocrinol. Invest. 16(3), 207–211 (1993)PubMedCrossRef D. Giuffrida, M.R. Garofalo, G. Cacciaguerra, V. Freni, A. Ippolito, C. Regalbuto, M.G. Santonocito, A. Belfiore, False positive 131I total body scan due to an ectasia of the common carotidis. J. Endocrinol. Invest. 16(3), 207–211 (1993)PubMedCrossRef
68.
Zurück zum Zitat B.L.M. Mena, C.J.A. Vallejo, O.E. Moreno, N.R. del Real, M.F.R. Maza, R.J.M. Latre, I-131 visualization of thoracic aortic aneurysm after radioiodine administration for thyroid carcinoma. Clin. Nucl. Med. 33(8), 553–554 (2008). doi:10.1097/RLU.0b013e31817deb95 CrossRef B.L.M. Mena, C.J.A. Vallejo, O.E. Moreno, N.R. del Real, M.F.R. Maza, R.J.M. Latre, I-131 visualization of thoracic aortic aneurysm after radioiodine administration for thyroid carcinoma. Clin. Nucl. Med. 33(8), 553–554 (2008). doi:10.​1097/​RLU.​0b013e31817deb95​ CrossRef
69.
Zurück zum Zitat E. Varoglu, M. Yildirim, R. Bayrakdar, A.M. Kantarci, H. Uslu, Radioiodine pooling in dilated greater saphenous vein mimicking contamination. Clin. Nucl. Med. 28(10), 866–868 (2003)PubMedCrossRef E. Varoglu, M. Yildirim, R. Bayrakdar, A.M. Kantarci, H. Uslu, Radioiodine pooling in dilated greater saphenous vein mimicking contamination. Clin. Nucl. Med. 28(10), 866–868 (2003)PubMedCrossRef
70.
Zurück zum Zitat V. Mohan, R.C. Jones, A.J. Drake, P.L. Daly, K.M. Shakir, Littoral cell angioma presenting as metastatic thyroid carcinoma to the spleen. Thyroid 15(2), 170–175 (2005)PubMedCrossRef V. Mohan, R.C. Jones, A.J. Drake, P.L. Daly, K.M. Shakir, Littoral cell angioma presenting as metastatic thyroid carcinoma to the spleen. Thyroid 15(2), 170–175 (2005)PubMedCrossRef
71.
Zurück zum Zitat R. Laguna, F. Silva, J. Vazquez-Sellés, E. Orduña, C. Flores, Vertebral hemangioma mimicking a metastatic bone lesion in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 25(8), 611–613 (2000)PubMedCrossRef R. Laguna, F. Silva, J. Vazquez-Sellés, E. Orduña, C. Flores, Vertebral hemangioma mimicking a metastatic bone lesion in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 25(8), 611–613 (2000)PubMedCrossRef
72.
Zurück zum Zitat F.J.P. Pena, A. Crespo de la Jara, F.J.M. Fernández, M.G. Sureda, J.V. Forteza, A.M. Brugarolas, Solitary focus in the liver in a thyroid cancer patient after a whole body scan with 131 Iodine. Rev. Esp. Med. Nucl. 26(5), 294–296 (2007)CrossRef F.J.P. Pena, A. Crespo de la Jara, F.J.M. Fernández, M.G. Sureda, J.V. Forteza, A.M. Brugarolas, Solitary focus in the liver in a thyroid cancer patient after a whole body scan with 131 Iodine. Rev. Esp. Med. Nucl. 26(5), 294–296 (2007)CrossRef
73.
Zurück zum Zitat F. Brucker-Davis, J.C. Reynolds, M.C. Skarulis, D.L. Fraker, H.R. Alexander, B.D. Weintraub, J. Robbins, False-positive iodine-131 whole-body scans due to cholecystitis and sebaceous cyst. J. Nucl. Med. 37(10), 1690–1693 (1996)PubMed F. Brucker-Davis, J.C. Reynolds, M.C. Skarulis, D.L. Fraker, H.R. Alexander, B.D. Weintraub, J. Robbins, False-positive iodine-131 whole-body scans due to cholecystitis and sebaceous cyst. J. Nucl. Med. 37(10), 1690–1693 (1996)PubMed
74.
Zurück zum Zitat H.T. Turoglu, S. Naddaf, I. Young, H.M. Abdel-Dayem, Infected sebaceous cyst. A cause for false-positive total-body I-123 metastatic survey for thyroid cancer. Clin. Nucl. Med. 21(11), 887 (1996)PubMedCrossRef H.T. Turoglu, S. Naddaf, I. Young, H.M. Abdel-Dayem, Infected sebaceous cyst. A cause for false-positive total-body I-123 metastatic survey for thyroid cancer. Clin. Nucl. Med. 21(11), 887 (1996)PubMedCrossRef
75.
Zurück zum Zitat V. Triggiani, M. Moschetta, V.A. Giagulli, B. Licchelli, E. Guastamacchia, Diffuse 131I lung uptake in bronchiectasis: a potential pitfall in the follow-up of differentiated thyroid carcinoma. Thyroid 22(12), 1287–1290 (2012). doi:10.1089/thy.2011.0439 PubMedCrossRef V. Triggiani, M. Moschetta, V.A. Giagulli, B. Licchelli, E. Guastamacchia, Diffuse 131I lung uptake in bronchiectasis: a potential pitfall in the follow-up of differentiated thyroid carcinoma. Thyroid 22(12), 1287–1290 (2012). doi:10.​1089/​thy.​2011.​0439 PubMedCrossRef
76.
Zurück zum Zitat H.C. Song, Y.J. Heo, S.M. Kim, H.S. Bom, Iodine-131 uptake in focal bronchiectasis mimicking metastatic thyroid cancer. Clin. Nucl. Med. 28(4), 351–352 (2003)PubMed H.C. Song, Y.J. Heo, S.M. Kim, H.S. Bom, Iodine-131 uptake in focal bronchiectasis mimicking metastatic thyroid cancer. Clin. Nucl. Med. 28(4), 351–352 (2003)PubMed
77.
Zurück zum Zitat I. Jong, K. Taubman, S. Schlicht, Bronchiectasis simulating pulmonary metastases on iodine-131 scintigraphy in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 30(10), 688–689 (2005)PubMedCrossRef I. Jong, K. Taubman, S. Schlicht, Bronchiectasis simulating pulmonary metastases on iodine-131 scintigraphy in well-differentiated thyroid carcinoma. Clin. Nucl. Med. 30(10), 688–689 (2005)PubMedCrossRef
79.
Zurück zum Zitat M.K. Picolos, M. Habra, A. Safdar, N.J. Sarlis, Inactive pulmonary tuberculosis mimicking metastasis from papillary thyroid carcinoma in diagnostic radioiodine whole-body scintigraphy. Thyroid 15(9), 1105–1106 (2005)PubMedCrossRef M.K. Picolos, M. Habra, A. Safdar, N.J. Sarlis, Inactive pulmonary tuberculosis mimicking metastasis from papillary thyroid carcinoma in diagnostic radioiodine whole-body scintigraphy. Thyroid 15(9), 1105–1106 (2005)PubMedCrossRef
80.
Zurück zum Zitat S.M. Bakheet, M.M. Hammami, J. Powe, M. Bazarbashi, H. Al, Suhaibani, Radioiodine uptake in inactive pulmonary tuberculosis. Eur. J. Nucl. Med. 26(6), 659–662 (1999)PubMedCrossRef S.M. Bakheet, M.M. Hammami, J. Powe, M. Bazarbashi, H. Al, Suhaibani, Radioiodine uptake in inactive pulmonary tuberculosis. Eur. J. Nucl. Med. 26(6), 659–662 (1999)PubMedCrossRef
81.
Zurück zum Zitat S.M. Bakheet, M.M. Hammami, J. Powe, Radioiodine uptake in rheumatoid arthritis-associated lung disease mimicking thyroid cancer metastases. Clin. Nucl. Med. 23(5), 319–320 (1998)PubMedCrossRef S.M. Bakheet, M.M. Hammami, J. Powe, Radioiodine uptake in rheumatoid arthritis-associated lung disease mimicking thyroid cancer metastases. Clin. Nucl. Med. 23(5), 319–320 (1998)PubMedCrossRef
82.
Zurück zum Zitat R. Höschl, D.H. Choy, B. Gandevia, Iodine-131 uptake in inflammatory lung disease: a potential pitfall in treatment of thyroid carcinoma. J. Nucl. Med. 29(5), 701–706 (1988)PubMed R. Höschl, D.H. Choy, B. Gandevia, Iodine-131 uptake in inflammatory lung disease: a potential pitfall in treatment of thyroid carcinoma. J. Nucl. Med. 29(5), 701–706 (1988)PubMed
83.
Zurück zum Zitat G. Mitchell, B.E. Pratt, L. Vini, V.R. McCready, C.L. Harmer, False positive 131I whole body scans in thyroid cancer. Br. J. Radiol. 73(870), 627–635 (2000)PubMedCrossRef G. Mitchell, B.E. Pratt, L. Vini, V.R. McCready, C.L. Harmer, False positive 131I whole body scans in thyroid cancer. Br. J. Radiol. 73(870), 627–635 (2000)PubMedCrossRef
85.
Zurück zum Zitat E. Siegel, B.A. Sachs, In vitro leukocyte uptake of 131-I labeled iodide, thyroxine and triiodothyronine, and its relation to thyroid function. J. Clin. Endocrinol. Metab. 24, 313–318 (1964)PubMedCrossRef E. Siegel, B.A. Sachs, In vitro leukocyte uptake of 131-I labeled iodide, thyroxine and triiodothyronine, and its relation to thyroid function. J. Clin. Endocrinol. Metab. 24, 313–318 (1964)PubMedCrossRef
86.
Zurück zum Zitat P.J. Van den Broek, L.F. Buys, R. Van Furth, Interaction of povidone-iodine compounds, phagocytic cells, and microorganisms. Antimicrob. Agents Chemother. 22(4), 593–597 (1982)PubMedPubMedCentralCrossRef P.J. Van den Broek, L.F. Buys, R. Van Furth, Interaction of povidone-iodine compounds, phagocytic cells, and microorganisms. Antimicrob. Agents Chemother. 22(4), 593–597 (1982)PubMedPubMedCentralCrossRef
87.
Zurück zum Zitat S.Y. Wu, T. Brown, N. Milne, R. Egbert, A. Kabok, K.P. Lyons, J. Hickey, Iodine 131 total body scan–extrathyroidal uptake of radioiodine. Semin. Nucl. Med. 16(1), 82–84 (1986)PubMedCrossRef S.Y. Wu, T. Brown, N. Milne, R. Egbert, A. Kabok, K.P. Lyons, J. Hickey, Iodine 131 total body scan–extrathyroidal uptake of radioiodine. Semin. Nucl. Med. 16(1), 82–84 (1986)PubMedCrossRef
88.
Zurück zum Zitat M.L. Maayan, J. Eisenberg, E.M. Lopez, M.A. Rothschild, Hepatic visualization after 131I in patients with thyroid carcinoma. N. Engl. J. Med. 295(22), 1258–1259 (1976)PubMed M.L. Maayan, J. Eisenberg, E.M. Lopez, M.A. Rothschild, Hepatic visualization after 131I in patients with thyroid carcinoma. N. Engl. J. Med. 295(22), 1258–1259 (1976)PubMed
89.
Zurück zum Zitat H.A. Ziessman, H. Bahar, F.H. Fahey, V. Dubiansky, Hepatic visualization on iodine-131 whole-body thyroid cancer scans. J. Nucl. Med. 28(9), 1408–1411 (1987)PubMed H.A. Ziessman, H. Bahar, F.H. Fahey, V. Dubiansky, Hepatic visualization on iodine-131 whole-body thyroid cancer scans. J. Nucl. Med. 28(9), 1408–1411 (1987)PubMed
90.
Zurück zum Zitat A. Ramos-Gabatin, W.T. Phillips, R.W. Ware, R. Blumhardt, Significance of diffuse hepatic uptake on radioiodine (1-131) diagnostic and post-therapeutic body scans. J. Nucl. Med. 30, 4 (1989) A. Ramos-Gabatin, W.T. Phillips, R.W. Ware, R. Blumhardt, Significance of diffuse hepatic uptake on radioiodine (1-131) diagnostic and post-therapeutic body scans. J. Nucl. Med. 30, 4 (1989)
91.
Zurück zum Zitat B. Schober, P. Cohen, D. Lyster, M. Charron, B. Lentle, Diffuse liver uptake of iodine-131. J. Nucl. Med. 31(9), 1575–1576 (1990)PubMed B. Schober, P. Cohen, D. Lyster, M. Charron, B. Lentle, Diffuse liver uptake of iodine-131. J. Nucl. Med. 31(9), 1575–1576 (1990)PubMed
92.
Zurück zum Zitat J.K. Chung, Y.J. Lee, J.M. Jeong, D.S. Lee, M.C. Lee, B.Y. Cho, C.S. Koh, Clinical significance of hepatic visualization on iodine-131 whole-body scan in patients with thyroid carcinoma. J. Nucl. Med. 38(8), 1191–1195 (1997)PubMed J.K. Chung, Y.J. Lee, J.M. Jeong, D.S. Lee, M.C. Lee, B.Y. Cho, C.S. Koh, Clinical significance of hepatic visualization on iodine-131 whole-body scan in patients with thyroid carcinoma. J. Nucl. Med. 38(8), 1191–1195 (1997)PubMed
94.
Zurück zum Zitat F.A. Tatar, E. Morita, P.H. Ituarte, R.R. Cavalieri, Q.Y. Duh, D.C. Price, A.E. Siperstein, O.H. Clark, Association between residual thyroid carcinoma and diffuse hepatic uptake of 131I following radioiodine ablation in postoperative total thyroidectomy patients. World J. Surg. 25(6), 718–722 (2001)PubMedCrossRef F.A. Tatar, E. Morita, P.H. Ituarte, R.R. Cavalieri, Q.Y. Duh, D.C. Price, A.E. Siperstein, O.H. Clark, Association between residual thyroid carcinoma and diffuse hepatic uptake of 131I following radioiodine ablation in postoperative total thyroidectomy patients. World J. Surg. 25(6), 718–722 (2001)PubMedCrossRef
95.
Zurück zum Zitat F. Vermiglio, E. Baudin, J.P. Travagli, B. Caillou, P. Fragu, M. Ricard, M. Schlumberger, Iodine concentration by the thymus in thyroid carcinoma. J. Nucl. Med. 37(11), 1830–1831 (1996)PubMed F. Vermiglio, E. Baudin, J.P. Travagli, B. Caillou, P. Fragu, M. Ricard, M. Schlumberger, Iodine concentration by the thymus in thyroid carcinoma. J. Nucl. Med. 37(11), 1830–1831 (1996)PubMed
96.
Zurück zum Zitat I.E. Veronikis, P. Simkin, L.E. Braverman, Thymic uptake of iodine-131 in the anterior mediastinum. J. Nucl. Med. 37(6), 991–992 (1996)PubMed I.E. Veronikis, P. Simkin, L.E. Braverman, Thymic uptake of iodine-131 in the anterior mediastinum. J. Nucl. Med. 37(6), 991–992 (1996)PubMed
97.
Zurück zum Zitat L. Montella, M. Caraglia, A. Abbruzzese, A. Soricelli, M. Caputi, G. Squame, M. Salvatore, S. Del Prete, G. Palmieri, Mediastinal images resembling thymus following 131-I treatment for thyroid cancer. Monaldi Arch. Chest Dis. 63(2), 114–117 (2005)PubMedCrossRef L. Montella, M. Caraglia, A. Abbruzzese, A. Soricelli, M. Caputi, G. Squame, M. Salvatore, S. Del Prete, G. Palmieri, Mediastinal images resembling thymus following 131-I treatment for thyroid cancer. Monaldi Arch. Chest Dis. 63(2), 114–117 (2005)PubMedCrossRef
98.
Zurück zum Zitat M. Salvatori, I. Saletnich, V. Rufini, L. Troncone, Unusual false-positive radioiodine whole-body scans in patients with differentiated thyroid carcinoma. Clin. Nucl. Med. 22(6), 380–384 (1997)PubMedCrossRef M. Salvatori, I. Saletnich, V. Rufini, L. Troncone, Unusual false-positive radioiodine whole-body scans in patients with differentiated thyroid carcinoma. Clin. Nucl. Med. 22(6), 380–384 (1997)PubMedCrossRef
99.
Zurück zum Zitat J. Andreas, K. Brühl, D. Eissner, False-positive I-131 whole-body imaging after I-131 therapy for a follicular carcinoma. Clin. Nucl. Med. 22(2), 123–124 (1997)PubMedCrossRef J. Andreas, K. Brühl, D. Eissner, False-positive I-131 whole-body imaging after I-131 therapy for a follicular carcinoma. Clin. Nucl. Med. 22(2), 123–124 (1997)PubMedCrossRef
100.
Zurück zum Zitat S. Modoni, G. Martino, M. Guerra, V. Frusciante, Unusual radioiodine uptake caused by metallic sutures in the skull in a patient with thyroid cancer. Clin. Nucl. Med. 25(12), 1053–1054 (2000)PubMedCrossRef S. Modoni, G. Martino, M. Guerra, V. Frusciante, Unusual radioiodine uptake caused by metallic sutures in the skull in a patient with thyroid cancer. Clin. Nucl. Med. 25(12), 1053–1054 (2000)PubMedCrossRef
101.
Zurück zum Zitat P.W. Wang, H.Y. Chen, C.H. Li, W.J. Chen, Uptake of I-131 by an abdominal neurilemoma mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 18(11), 964–966 (1993)PubMedCrossRef P.W. Wang, H.Y. Chen, C.H. Li, W.J. Chen, Uptake of I-131 by an abdominal neurilemoma mimicking metastatic thyroid carcinoma. Clin. Nucl. Med. 18(11), 964–966 (1993)PubMedCrossRef
102.
Zurück zum Zitat P. Sinha, G.R. Conrad, M. Holzhauer, Incidental detection of a falx meningioma on post-therapy radioiodide whole-body imaging. Clin. Nucl. Med. 27(12), 916–917 (2002)PubMedCrossRef P. Sinha, G.R. Conrad, M. Holzhauer, Incidental detection of a falx meningioma on post-therapy radioiodide whole-body imaging. Clin. Nucl. Med. 27(12), 916–917 (2002)PubMedCrossRef
103.
Zurück zum Zitat S.C. Ong, D.N. Eng, F.X. Sundram, L.L. Chan, A novel case of false-positive I-131 whole-body scan in thyroid carcinoma caused by subdural hematoma. Clin. Nucl. Med. 29(3), 164–166 (2004)PubMedCrossRef S.C. Ong, D.N. Eng, F.X. Sundram, L.L. Chan, A novel case of false-positive I-131 whole-body scan in thyroid carcinoma caused by subdural hematoma. Clin. Nucl. Med. 29(3), 164–166 (2004)PubMedCrossRef
104.
Zurück zum Zitat M. Lungo, F. Tenenbaum, P. Chaumerliac, C. Vons, A. Mirat, F. Beuzen, J.P. Luton, B. Richard, Ovarian endometriosis cyst with iodine 131 uptake: first case of false positive in the follow up for differentiated thyroid carcinoma. Ann. Endocrinol. 61(2), 147–150 (2000) M. Lungo, F. Tenenbaum, P. Chaumerliac, C. Vons, A. Mirat, F. Beuzen, J.P. Luton, B. Richard, Ovarian endometriosis cyst with iodine 131 uptake: first case of false positive in the follow up for differentiated thyroid carcinoma. Ann. Endocrinol. 61(2), 147–150 (2000)
105.
Zurück zum Zitat M.H. Sohn, M.W. Kim, S.T. Lim, N.R. Lee, E.K. Song, C.Y. Yim, Radioiodine uptake by metastatic nonthyroidal adenocarcinoma of the lung in a patient with papillary thyroid carcinoma. Clin. Nucl. Med. 30(4), 269–270 (2005)PubMedCrossRef M.H. Sohn, M.W. Kim, S.T. Lim, N.R. Lee, E.K. Song, C.Y. Yim, Radioiodine uptake by metastatic nonthyroidal adenocarcinoma of the lung in a patient with papillary thyroid carcinoma. Clin. Nucl. Med. 30(4), 269–270 (2005)PubMedCrossRef
106.
Zurück zum Zitat S. Muherji, H.A. Ziessman, J.M. Earll, J.W. Jr, Keyes, False-positive iodine-131 whole body scan due to pectus excavatum. Clin. Nucl. Med. 13(3), 207–208 (1988)PubMedCrossRef S. Muherji, H.A. Ziessman, J.M. Earll, J.W. Jr, Keyes, False-positive iodine-131 whole body scan due to pectus excavatum. Clin. Nucl. Med. 13(3), 207–208 (1988)PubMedCrossRef
107.
Zurück zum Zitat S.Y. Naddaf, M.F. Akisik, W.S. Omar, I. Young, H.M. Abdel-Dayem, I-123 uptake in the chest wall after needle biopsy of a pulmonary nodule. A cause for false-positive I-123 uptake. Clin. Nucl. Med. 22(8), 572–573 (1997)PubMedCrossRef S.Y. Naddaf, M.F. Akisik, W.S. Omar, I. Young, H.M. Abdel-Dayem, I-123 uptake in the chest wall after needle biopsy of a pulmonary nodule. A cause for false-positive I-123 uptake. Clin. Nucl. Med. 22(8), 572–573 (1997)PubMedCrossRef
108.
Zurück zum Zitat D.P. Greenler, H.A. Klein, The scope of false-positive iodine-131 images for thyroid carcinoma. Clin. Nucl. Med. 14(2), 111–117 (1989)PubMedCrossRef D.P. Greenler, H.A. Klein, The scope of false-positive iodine-131 images for thyroid carcinoma. Clin. Nucl. Med. 14(2), 111–117 (1989)PubMedCrossRef
109.
Zurück zum Zitat I.R. McDougall, Whole-body scintigraphy with radioiodine-131. A comprehensive list of false-positives with some examples. Clin. Nucl. Med. 20(10), 869–875 (1995)PubMedCrossRef I.R. McDougall, Whole-body scintigraphy with radioiodine-131. A comprehensive list of false-positives with some examples. Clin. Nucl. Med. 20(10), 869–875 (1995)PubMedCrossRef
110.
Zurück zum Zitat A. Waxman, L. Ramanna, N. Chapman, D. Chapman, M. Brachman, D. Tanasescu, D. Berman, B. Catz, G. Braunstein, The significance of 1-131 scan dose in patients with thyroid cancer: determination of ablation: concise communication. J. Nucl. Med. 22(10), 861–865 (1981)PubMed A. Waxman, L. Ramanna, N. Chapman, D. Chapman, M. Brachman, D. Tanasescu, D. Berman, B. Catz, G. Braunstein, The significance of 1-131 scan dose in patients with thyroid cancer: determination of ablation: concise communication. J. Nucl. Med. 22(10), 861–865 (1981)PubMed
111.
Zurück zum Zitat S. Rudoni, M. Toubeau, S. Mansuy, G. Vaillant, B. Verges, J.M. Brun, F. Brunotte, False positive scintigraphic images in the surveillance of differentiated thyroid cancers. Ann. Endocrinol. 58(5), 399–407 (1997) S. Rudoni, M. Toubeau, S. Mansuy, G. Vaillant, B. Verges, J.M. Brun, F. Brunotte, False positive scintigraphic images in the surveillance of differentiated thyroid cancers. Ann. Endocrinol. 58(5), 399–407 (1997)
112.
Zurück zum Zitat M. Blum, Hepatic visualization after 131I in patients with thyroid carcinoma. N. Engl. J. Med. 296(11), 634 (1977)PubMed M. Blum, Hepatic visualization after 131I in patients with thyroid carcinoma. N. Engl. J. Med. 296(11), 634 (1977)PubMed
113.
Zurück zum Zitat M.R. Carlisle, C. Lu, I.R. McDougall, The interpretation of 131I scans in the evaluation of thyroid cancer, with an emphasis on false positive findings. Nucl. Med. Commun. 24(6), 715–735 (2003)PubMedCrossRef M.R. Carlisle, C. Lu, I.R. McDougall, The interpretation of 131I scans in the evaluation of thyroid cancer, with an emphasis on false positive findings. Nucl. Med. Commun. 24(6), 715–735 (2003)PubMedCrossRef
114.
Zurück zum Zitat Y. Maruoka, K. Abe, S. Baba, T. Isoda, H. Sawamoto, Y. Tanabe, M. Sasaki, H. Honda, Incremental diagnostic value of SPECT/CT with 131I scintigraphy after radioiodine therapy in patients with well-differentiated thyroid carcinoma. Radiology 265(3), 902–909 (2012). doi:10.1148/radiol.12112108 PubMedCrossRef Y. Maruoka, K. Abe, S. Baba, T. Isoda, H. Sawamoto, Y. Tanabe, M. Sasaki, H. Honda, Incremental diagnostic value of SPECT/CT with 131I scintigraphy after radioiodine therapy in patients with well-differentiated thyroid carcinoma. Radiology 265(3), 902–909 (2012). doi:10.​1148/​radiol.​12112108 PubMedCrossRef
Metadaten
Titel
False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers
verfasst von
Vincenzo Triggiani
Vito Angelo Giagulli
Michele Iovino
Giovanni De Pergola
Brunella Licchelli
Antonio Varraso
Franca Dicembrino
Guido Valle
Edoardo Guastamacchia
Publikationsdatum
26.10.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2016
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-015-0750-3

Weitere Artikel der Ausgabe 3/2016

Endocrine 3/2016 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Reizdarmsyndrom: Diäten wirksamer als Medikamente

29.04.2024 Reizdarmsyndrom Nachrichten

Bei Reizdarmsyndrom scheinen Diäten, wie etwa die FODMAP-arme oder die kohlenhydratreduzierte Ernährung, effektiver als eine medikamentöse Therapie zu sein. Das hat eine Studie aus Schweden ergeben, die die drei Therapieoptionen im direkten Vergleich analysierte.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.