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International Journal of Clinical Oncology

Erschienen in:

01.06.2013 | Original Article

Feasibility and toxicity of docetaxel before or after fluorouracil, epirubicin and cyclophosphamide as adjuvant chemotherapy for early breast cancer

verfasst von: Hajime Abe, Tsuyoshi Mori, Yuki Kawai, Hirotomi Cho, Yoshihiro Kubota, Tomoko Umeda, Yoshimasa Kurumi, Tohru Tani

Erschienen in: International Journal of Clinical Oncology | Ausgabe 3/2013

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Abstract

Background

The tolerance and safety associated with the administration order of the anthracycline and taxane drugs have not been evaluated.

Patients and methods

Breast cancer patients with node-positive or high-risk patients with node-negative were eligible. The feasibility and toxicity were evaluated in the following regimens—arm A, 3 courses of fluorouracil 500 mg/m², epirubicin 100 mg/m² and cyclophosphamide 500 mg/m² (FEC) followed by 3 courses of docetaxel 100 mg/m² (DOC); arm B, 3 courses of DOC followed by 3 courses of FEC.

Results

Forty-two patients were registered. The relative dose intensity was 94.2 % for FEC and 97.8 % for DOC in arm A, and 98.9 % for DOC and 95.2 % for FEC in arm B. In arm A, grade 3 or higher hematological toxicity was observed in nine patients, and febrile neutropenia developed in three patients with FEC. In arm B, grade 3 or higher hematological toxicity was observed in seven patients, but febrile neutropenia was not noted in any patient.

Conclusion

The regimens in both arms A and B were safe regarding adjuvant chemotherapy for early breast cancer. However, DOC followed by FEC might be more tolerable. Further studies will maximize the results obtained with DOC followed by FEC.

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Titel: Feasibility and toxicity of docetaxel before or after fluorouracil, epirubicin and cyclophosphamide as adjuvant chemotherapy for early breast cancer
verfasst von: Hajime Abe
Tsuyoshi Mori
Yuki Kawai
Hirotomi Cho
Yoshihiro Kubota
Tomoko Umeda
Yoshimasa Kurumi
Tohru Tani
Publikationsdatum: 01.06.2013
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 3/2013
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-012-0407-7

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Feasibility and toxicity of docetaxel before or after fluorouracil, epirubicin and cyclophosphamide as adjuvant chemotherapy for early breast cancer