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Erschienen in:

20.05.2023 | Cardiac

Feasibility of accelerated non-contrast-enhanced whole-heart bSSFP coronary MR angiography by deep learning–constrained compressed sensing

verfasst von: Xi Wu, Lu Tang, Wanjiang Li, Shuai He, Xun Yue, Pengfei Peng, Tao Wu, Xiaoyong Zhang, Zhigang Wu, Yong He, Yucheng Chen, Juan Huang, Jiayu Sun

Erschienen in: European Radiology | Ausgabe 11/2023

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Abstract

Objectives

To examine a compressed sensing artificial intelligence (CSAI) framework to accelerate image acquisition in non-contrast-enhanced whole-heart bSSFP coronary magnetic resonance (MR) angiography.

Methods

Thirty healthy volunteers and 20 patients with suspected coronary artery disease (CAD) scheduled for coronary computed tomography angiography (CCTA) were enrolled. Non-contrast-enhanced coronary MR angiography was performed with CSAI, compressed sensing (CS), and sensitivity encoding (SENSE) methods in healthy participants and with CSAI in patients. Acquisition time, subjective image quality score, and objective image quality measurement (blood pool homogeneity, signal-to-noise ratio [SNR], and contrast-to-noise ratio [CNR]) were compared among the three protocols. The diagnostic performance of CASI coronary MR angiography for predicting significant stenosis (≥ 50% diameter stenosis) on CCTA was evaluated. The Friedman test was performed to compare the three protocols.

Results

Acquisition time was significantly shorter in the CSAI and CS groups than in the SENSE group (10.2 ± 3.2 min vs. 10.9 ± 2.9 min vs. 13.0 ± 4.1 min, p < 0.001). However, the CSAI approach had the highest image quality scores, blood pool homogeneity, mean SNR value, and mean CNR value (all p < 0.001) compared with the CS and SENSE approaches. The sensitivity, specificity, and accuracy of CSAI coronary MR angiography per patient were 87.5% (7/8), 91.7% (11/12), and 90.0% (18/20); those per vessel were 81.8% (9/11), 93.9% (46/49), and 91.7% (55/60); and those per segment were 84.6% (11/13), 98.0% (244/249), and 97.3% (255/262), respectively.

Conclusions

CSAI yielded superior image quality within a clinically feasible acquisition time in healthy participants and patients with suspected CAD.

Clinical relevance statement

The non-invasive and radiation-free CSAI framework could be a promising tool for rapid screening and comprehensive examination of the coronary vasculature in patients with suspected CAD.

Key Points

• This prospective study showed that CSAI enables a reduction in acquisition time by 22% with superior diagnostic image quality compared with the SENSE protocol.

• CSAI replaces the wavelet transform with a CNN as a sparsifying transform in the CS algorithm, achieving high coronary MR image quality with reduced noise.

• CSAI achieved per-patient sensitivity of 87.5% (7/8) and specificity of 91.7% (11/12) respectively for detecting significant coronary stenosis.

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Titel: Feasibility of accelerated non-contrast-enhanced whole-heart bSSFP coronary MR angiography by deep learning–constrained compressed sensing
verfasst von: Xi Wu
Lu Tang
Wanjiang Li
Shuai He
Xun Yue
Pengfei Peng
Tao Wu
Xiaoyong Zhang
Zhigang Wu
Yong He
Yucheng Chen
Juan Huang
Jiayu Sun
Publikationsdatum: 20.05.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2023
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-09740-8

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Feasibility of accelerated non-contrast-enhanced whole-heart bSSFP coronary MR angiography by deep learning–constrained compressed sensing