Erschienen in:
28.08.2015 | Original Article
Feasibility of the liver-first approach for patients with initially unresectable and not optimally resectable synchronous colorectal liver metastases
verfasst von:
Masayuki Okuno, Etsuro Hatano, Yosuke Kasai, Takahiro Nishio, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Takashi Nitta, Akira Mori, Hideaki Okajima, Toshimi Kaido, Suguru Hasegawa, Shigemi Matsumoto, Yoshiharu Sakai, Shinji Uemoto
Erschienen in:
Surgery Today
|
Ausgabe 6/2016
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Abstract
Purpose
To investigate the outcomes of patients with colorectal cancer and initially unresectable or not optimally resectable liver metastases, who were treated using the liver-first approach in the era of modern chemotherapy in Japan.
Methods
We analyzed and compared data retrospectively on patients with asymptomatic resectable colorectal cancer and initially unresectable or not optimally resectable liver metastases, who were treated either using the liver-first approach (n = 12, LF group) or the primary-first approach (n = 13, PF group).
Results
Both groups of patients completed their therapeutic plan and there was no mortality. Postoperative morbidity rates after primary resection and hepatectomy, and post-hepatectomy liver failure rate were comparable between the groups (p = 1.00, p = 0.91, and p = 0.55, respectively). Recurrence rates, median recurrence-free survival since the last operation, and 3-year overall survival rates from diagnosis were also comparable between the LF and PF groups (58.3 vs. 61.5 %, p = 0.87; 10.5 vs. 18.6 months, p = 0.57; and 87.5 vs. 82.5 %, p = 0.46, respectively).
Conclusions
The liver-first approach may be an appropriate treatment sequence without adversely affecting perioperative or survival outcomes for selected patients.