Background
Methods
Publication search
Inclusion, exclusion criteria and data abstraction
Statistical analysis
Results
Study characteristics
First author | Year | Ethnicity | Cases | Controls | Case | Control | Pathological parameters of cases | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gly/Gly | Gly/Arg | Arg/Arg | Gly/Gly | Gly/Arg | Arg/Arg | ||||||
Wang | 2004 | Caucasian | 284 | 97 | 125 | 117 | 42 | 53 | 40 | 4 | Stratified by Gleason score (7-9 vs. 5-6), pathological stage (T3 vs. T2), lymph node metastasis (positive vs. negative), and PSA recurrence (positive vs. negative) |
Wang | 2004 | African American | 45 | 94 | 37 | 6 | 2 | 76 | 18 | 0 | |
FitzGerald | 2009 | Caucasian | 1254 | 1251 | 587 | 544 | 123 | 631 | 496 | 124 | Stratified by Gleason score [≥7(4+3) vs.≤7(3+4)], and pathological stage (regional/distant vs. local) |
FitzGerald | 2009 | African American | 146 | 80 | 104 | 39 | 3 | 60 | 18 | 2 | |
Ho | 2009 | Caucasian | 397 | 439 | 183 | 182 | 32 | 235 | 167 | 37 | - |
Ma | 2008 | Asian | 492 | 344 | 163 | 196 | 133 | 125 | 152 | 67 | Stratified by tumor stage (stage D vs. A+B+C) a, and Gleason score (8-10 vs. 2-7) |
Quantitative synthesis
Variables | na | Cases/controls | Arg vs. Gly | Arg/Arg vs. Gly/Gly | Gly/Arg+Arg/Arg vs. Gly/Gly | Arg/Arg vs. Gly/Gly+ Gly/Arg | ||||
---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Pb | OR (95% CI) | Pb | OR (95% CI) | Pb | OR (95% CI) | Pb | |||
Total | 5 | 2618/2305 | 1.17 (1.07-1.29) | 0.37 | 1.39 (0.97-1.99) | 0.08 | 1.21 (1.08-1.36) | 0.79 | 1.32 (0.90-1.94)c | 0.03 |
Caucasian | 3 | 1935/1787 | 1.21 (1.00-1.47) | 0.09 | 1.40 (0.80-2.45)c | 0.04 | 1.23 (1.08-1.40) | 0.39 | 1.26 (0.72-2.19)c | 0.04 |
African | 2 | 191/174 | 1.15 (0.73-1.82) | 0.95 | 2.17 (0.20-23.14) | 0.17 | 1.11 (0.66-1.86) | 0.62 | 2.21 (0.18-26.83) | 0.15 |
Asian | 1 | 492/344 | 1.24 (1.02-1.51) | - | 1.52 (1.05-2.22) | - | 1.15 (0.86-1.54) | - | 1.53 (1.10-2.14) | - |
Tumor stage | ||||||||||
Localized | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||||
Advanced | 1.18 (0.96-1.44) | 0.75 | 1.33 (0.91-1.96) | 0.89 | 1.01 (0.93-1.10) | 0.44 | 1.34 (1.03-1.74) | 0.61 |