nach oben

Angiogenesis

Erschienen in:

01.06.2009 | Review Paper

Fibronectins in vascular morphogenesis

verfasst von: Sophie Astrof, Richard O. Hynes

Erschienen in: Angiogenesis | Ausgabe 2/2009

Einloggen, um Zugang zu erhalten

Abstract

Fibronectin is an extracellular matrix protein found only in vertebrate organisms containing endothelium-lined vasculature and is required for cardiovascular development in fish and mice. Fibronectin and its splice variants containing EIIIA and EIIIB domains are highly upregulated around newly developing vasculature during embryogenesis and in pathological conditions including atherosclerosis, cardiac hypertrophy, and tumorigenesis. However, their molecular roles in these processes are not entirely understood. We review genetic studies examining functions of fibronectin and its splice variants during embryonic cardiovascular development, and discuss potential roles of fibronectin in vascular disease and tumor angiogenesis.

Coultas L et al (2005) Endothelial cells and VEGF in vascular development. Nature 438:937–945PubMed

Hodivala-Dilke K (2008) Alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 20:514–519PubMed

Hynes RO (2007) Cell-matrix adhesion in vascular development. J Thromb Haemost 5(Suppl 1):32–40PubMed

Armulik A et al (2005) Endothelial/pericyte interactions. Circ Res 97:512–523PubMed

Bergers G, Song S (2005) The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 7:452–464PubMed

von Tell D et al (2006) Pericytes and vascular stability. Exp Cell Res 312:623–629

George EL et al (1997) Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood 90:3073–3081PubMed

George EL et al (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079–1091PubMed

Georges-Labouesse EN et al (1996) Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn 207:145–156PubMed

10.

Francis SE et al (2002) Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol 22:927–933PubMed

11.

Lucitti JL et al (2007) Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development 134:3317–3326PubMed

12.

Astrof S et al (2007) Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech Dev 124:551–558PubMed

13.

Trinh LA, Stainier DY (2004) Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell 6:371–382PubMed

14.

Koshida S et al (2005) Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell 8:587–598PubMed

15.

Marsden M, DeSimone DW (2001) Regulation of cell polarity, radial intercalation and epiboly in Xenopus: novel roles for integrin and fibronectin. Development 128:3635–3647PubMed

16.

Katsuno T et al (2008) Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell 19:2465–2475PubMed

17.

Ikenouchi J et al (2007) Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization. J Cell Biol 176:779–786PubMed

18.

Umeda K et al (2006) ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 126:741–754PubMed

19.

Buchner DA et al (2007) Pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A 104:13996–14001PubMed

20.

Kamei M et al (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature 442:453–456PubMed

21.

Koh W et al (2008) Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. J Cell Sci 121:989–1001PubMed

22.

Giancotti FG, Tarone G (2003) Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol 19:173–206PubMed

23.

Hynes RO et al (2002) The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol 67:143–153PubMed

24.

Yang JT, Hynes RO (1996) Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. Mol Biol Cell 7:1737–1748PubMed

25.

Taverna D, Hynes RO (2001) Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies. Cancer Res 61:5255–5261PubMed

26.

Aota S et al (1994) The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem 269:24756–24761PubMed

27.

Hynes RO (1990) Fibronectins. Springer-Verlag, New York

28.

Takahashi S et al (2007) The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol 178:167–178PubMed

29.

Bader BL et al (1998) Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95:507–519PubMed

30.

Grazioli A et al (2006) Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos. Dev Biol 293:165–177PubMed

31.

Wijelath ES et al (2002) Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity. Circ Res 91:25–31PubMed

32.

Wijelath ES et al (2006) Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res 99:853–860PubMed

33.

Lee S et al (2005) Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169:681–691PubMed

34.

Carmeliet P et al (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med 5:495–502PubMed

35.

Maes C et al (2004) Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest 113:188–199PubMed

36.

Zhou X et al (2008) Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev 22:1231–1243PubMed

37.

Bayless et al (2000) RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins. Am J Pathol 156:1673–1683PubMed

38.

McCarty JH et al (2002) Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol 22:7667–7677PubMed

39.

Yang JT et al (1999) Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol 215:264–277PubMed

40.

Carlson TR et al (2008) Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion migration and survival during angiogenesis in mice. Development 135:2193–2202PubMed

41.

Wierzbicka-Patynowski I, Schwarzbauer JE (2003) The ins and outs of fibronectin matrix assembly. J Cell Sci 116:3269–3276PubMed

42.

White ES et al (2008) New insights into form and function of fibronectin splice variants. J Pathol 216:1–14PubMed

43.

Astrof S et al (2007) Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol 311:11–24PubMed

44.

Dickson MC et al (1995) Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121:1845–1854PubMed

45.

Ferrara N et al (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439–442PubMed

46.

Lee SH et al (2000) Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor. J Biol Chem 275:33679–33687PubMed

47.

Suri C et al (1996) Requisite role of angiopoietin–1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171–1180PubMed

48.

Miyamoto S et al (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 135:1633–1642PubMed

49.

Reinhart-King CA et al (2005) The dynamics and mechanics of endothelial cell spreading. Biophys J 89:676–689PubMed

50.

Davidson LA et al (2008) Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Dev Dyn 237:2684–2692PubMed

51.

Erickson HP (1994) Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. Proc Natl Acad Sci U S A 91:10114–10118PubMed

52.

Liao YF et al (2002) The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem 277:14467–14474PubMed

53.

Okamura Y et al (2001) The extra domain A of fibronectin activates toll-like receptor 4. J Biol Chem 276:10229–10233PubMed

54.

Shinde AV et al (2008) Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities. J Biol Chem 283:2858–2870PubMed

55.

Huang XZ et al (2000) Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol 20:5208–5215PubMed

56.

Li S et al (2003) The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A 100:9366–9370PubMed

57.

Serini G et al (1998) The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873–881PubMed

58.

High FA et al (2007) An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117:353–363PubMed

59.

Hirschi et al (2003) Gap junction communication mediates transforming growth factor-{beta} activation and endothelial-induced mural cell differentiation. Circ Res 93:429–437PubMed

60.

Wurdak H et al (2005) Inactivation of TGF{beta} signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 19:530–535PubMed

61.

Lindblom P et al (2003) Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev 17:1835–1840PubMed

62.

Abramsson A et al (2003) Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 112:1142–1151PubMed

63.

Hellstrom M et al (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126:3047–3055PubMed

64.

Majesky MW (2007) Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol 27:1248–1258PubMed

65.

Esner M et al (2006) Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome. Development 133:737–749PubMed

66.

Snider P et al (2007) Cardiovascular development and the colonizing cardiac neural crest lineage. Scientific World J 7:1090–1113

67.

Ffrench-Constant C, Hynes RO (1988) Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos. Development 104:369–382PubMed

68.

Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653–660PubMed

69.

Cascone I et al (2005) Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang–1. J Cell Biol 170:993–1004PubMed

70.

Sheppard J et al (1994) Expanding roles for alpha 4 integrin and its ligands in development. Cell Adhes Commun 2:27–43PubMed

71.

Vlahakis NE et al (2005) The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem 280:4544–4552PubMed

72.

Bergers G et al (1999) Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284:808–812PubMed

73.

Bergers G et al (2003) Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111:1287–1295PubMed

74.

Morikawa S et al (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 160:985–1000PubMed

75.

Benjamin LE, Keshet E (1997) Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA 94:8761–8766PubMed

76.

Sennino B et al (2007) Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 67:7358–7367PubMed

77.

Owens GK et al (2004) Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84:767–801PubMed

78.

Dzau VJ et al (2002) Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 8:1249–1256PubMed

79.

Glukhova MA et al (1989) Expression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent. J Cell Biol 109:357–366PubMed

80.

Rosamond W et al (2007) Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115:e69–e171PubMed

81.

Babaev VR et al (2008) Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice. Atherosclerosis 197:534–540PubMed

82.

Tan MH et al (2004) Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood 104:11–18PubMed

83.

Dangas G, Kuepper F (2002) Cardiology patient page. Restenosis: repeat narrowing of a coronary artery: prevention and treatment. Circulation 105:2586–2587PubMed

84.

Dubin D et al (1995) Balloon catheterization induces arterial expression of embryonic fibronectins. Arterioscler Thromb Vasc Biol 15:1958–1967PubMed

85.

Samuel JL et al (1991) Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload. J Clin Invest 88:1737–1746PubMed

86.

Coito AJ et al (1997) Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts. Am J Pathol 150:1757–1772PubMed

87.

Cai CL et al (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature 454:104–108PubMed

88.

Zhou B et al (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454:109–113PubMed

89.

Lepilina A et al (2006) A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127:607–619PubMed

90.

Castellani P et al (1994) The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int J Cancer 59:612–618PubMed

91.

Castellani P et al (2002) Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. Am J Pathol 161:1695–1700PubMed

92.

D’Ovidio MC et al (1998) Intratumoral microvessel density and expression of ED-A/ED-B sequences of fibronectin in breast carcinoma. Eur J Cancer 34:1081–1085PubMed

93.

Inufusa H et al (1995) Localization of oncofetal and normal fibronectin in colorectal cancer. Correlation with histologic grade, liver metastasis, and prognosis. Cancer 75:2802–2808PubMed

94.

Kaczmarek J et al (1994) Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues. Int J Cancer 59:11–16PubMed

95.

Lohi J et al (1995) Tenascin and fibronectin isoforms in human renal cell carcinomas, renal cell carcinoma cell lines and xenografts in nude mice. Int J Cancer 63:442–449PubMed

96.

Kosmehl H et al (1999) Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma. Br J Cancer 81:1071–1079PubMed

97.

Matsumoto E et al (1999) Expression of fibronectin isoforms in human breast tissue: production of extra domain A +/extra domain B + by cancer cells and extra domain A + by stromal cell. Jap J Cancer Res 90:320–325

98.

Oyama F et al (1989) Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J Biol Chem 264:10331–10334PubMed

99.

Oyama F et al (1990) Oncodevelopmental regulation of the alternative splicing of fibronectin pre-messenger RNA in human lung tissues. Cancer Res 50:1075–1078PubMed

100.

Pujuguet P et al (1996) Expression of fibronectin ED-A + and ED-B + isoforms by human and experimental colorectal cancer. Contribution of cancer cells and tumor-associated myofibroblasts. Am J Pathol 148:579–592PubMed

101.

Scarpino S et al (1999) Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid. J Pathol 188:163–167PubMed

102.

Ohnishi T et al (1998) Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues. Clin Exp Metastasis 16:729–741PubMed

103.

Astrof S et al (2004) Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol Cell Biol 24:8662–8670PubMed

104.

Ruoslahti E (2002) Specialization of tumour vasculature. Nat Rev Cancer 2:83–90PubMed

105.

Borsi L et al (2002) Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int J Cancer 102:75–85PubMed

106.

Nilsson F et al (2001) Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res 61:711–716PubMed

107.

Kaspar M et al (2006) Fibronectin as target for tumor therapy. Int J Cancer 118:1331–1339PubMed

108.

Villa A et al (2008) A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo. Int J Cancer 122:2405–2413PubMed

109.

Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58–62PubMed

110.

Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592–603PubMed

111.

Batchelor TT et al (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11:83–95PubMed

Titel: Fibronectins in vascular morphogenesis
verfasst von: Sophie Astrof
Richard O. Hynes
Publikationsdatum: 01.06.2009
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 2/2009
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-009-9136-6

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2009

Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature

Vasculogenesis in infantile hemangioma

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

The role of the Angiopoietins in vascular morphogenesis

Endogenous endothelial cell signaling systems maintain vascular stability