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Journal of Cancer Research and Clinical Oncology

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01.03.2015 | Original Article – Clinical Oncology

Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer

verfasst von: Marta Scorsetti, Tiziana Comito, Angelo Tozzi, Pierina Navarria, Antonella Fogliata, Elena Clerici, Pietro Mancosu, Giacomo Reggiori, Lorenza Rimassa, Guido Torzilli, Stefano Tomatis, Armando Santoro, Luca Cozzi

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2015

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Abstract

Purpose

To evaluate the feasibility and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of colorectal liver metastases.

Methods

Forty-two patients with inoperable colorectal liver metastases not amenable to radiofrequency ablation (RFA) were treated with SBRT for a total number of 52 lesions. All patients received a total dose of 75 Gy in 3 consecutive fractions. Mean size of the lesions was 3.5 cm (range 1.1–5.4). Toxicity was classified according to the Common Toxicity Criteria version 3.0.

Results

Median follow-up was 24 (range 4–47) months. The progression in field was observed in 5 lesions. Twenty-four months actuarial local control (LC) rate was 91 %. Median overall survival (OS) was 29.2 ± 3.7 months. Actuarial OS rate at 24 months was 65 %. Median progression-free survival was 12.0 ± 4.2 months; 24 months actuarial rate was 35 %. No patients experienced radiation-induced liver disease or grade ≥3 toxicity.

Conclusions

SBRT represents a feasible alternative for the treatment of colorectal liver metastases not amenable to surgery or other ablative treatments in selected patients, showing optimal LC and promising survival rate.

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Titel: Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer
verfasst von: Marta Scorsetti
Tiziana Comito
Angelo Tozzi
Pierina Navarria
Antonella Fogliata
Elena Clerici
Pietro Mancosu
Giacomo Reggiori
Lorenza Rimassa
Guido Torzilli
Stefano Tomatis
Armando Santoro
Luca Cozzi
Publikationsdatum: 01.03.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2015
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-014-1833-x

Springer Medizin

Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer