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12.04.2023

First-Line Therapy for Nodal T-cell Non-Hodgkin Lymphomas: an Unmet Need in Hematology

verfasst von: Vibor Milunović, Inga Mandac Smoljanović, Martina Bogeljić Patekar, Viktor Zatezalo, Marin Kursar, Delfa Radić-Krišto, Slobodanka Ostojić Kolonić, Slavko Gašparov

Erschienen in: Current Oncology Reports | Ausgabe 7/2023

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Abstract

Purposeof Review

The main aim of this review is to summarize first-line therapy of nodal T-cell non-Hodgkin lymphoma.

Recent Findings

Current treatment with CHOP chemotherapy results in poor outcomes in the majority of patients. However, there are advances within the field. First breakthrough is the ECHELON-2 trial which showed that the addition of brentuximab vedotin improves outcomes in anaplastic large cell lymphoma. However, other types of peripheral T-cell non-Hodgkin lymphoma were underrepresented with optimal treatment not known. Second breakthrough is an increase of autologous stem cell transplantation usage in the first complete metabolic remission, except in ALK + anaplastic large cell lymphoma, offering better disease control.

Summary

Despite advances in the field, CHOP remains the standard treatment for the majority of these lymphomas, but multiple trials are underway with the aim to improve this unmet need in hematology and, hopefully, leading us to a new era in the treatment of peripheral T-cell lymphomas.

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Titel: First-Line Therapy for Nodal T-cell Non-Hodgkin Lymphomas: an Unmet Need in Hematology
verfasst von: Vibor Milunović
Inga Mandac Smoljanović
Martina Bogeljić Patekar
Viktor Zatezalo
Marin Kursar
Delfa Radić-Krišto
Slobodanka Ostojić Kolonić
Slavko Gašparov
Publikationsdatum: 12.04.2023
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 7/2023
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-023-01400-w

Springer Medizin

First-Line Therapy for Nodal T-cell Non-Hodgkin Lymphomas: an Unmet Need in Hematology