nach oben

World Journal of Urology

Erschienen in:

07.04.2020 | Topic Paper

Five compelling UTI questions after kidney transplant

verfasst von: Selda Aydın, Abhijit Patil, Mahesh Desai, Nasser Simforoosh

Erschienen in: World Journal of Urology | Ausgabe 11/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Urinary tract infection (UTI) is the most common bacterial infection among infectious complications in kidney transplant recipients (KTR). After transplantation, infections can result from surgical complications, donor-derived infections, pre-existing recipient infections, and nosocomial infections. Post-transplant infection is still a major cause of morbidity, mortality, graft dysfunction and rejection. In this paper, we aimed to review a few compelling questions in kidney transplantation (KTX).

Methods

To identify relevant clinical questions regarding KTX and UTI a meeting was conducted among physicians involved in the KT program in our hospital. After discussion, several clinically relevant questions related to UTI after KTX. The 5 first rated in importance were judged generalizable to other clinical settings and selected for the purposes of this review.

Results

Nearly half of the patients present in the first three months of transplant with UTI. The most common uropathogens in post-transplant UTIs are Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis. Risk factors for UTI include female sex, advanced age, recurrent UTI before transplant, prolonged urethral catheterization, delayed graft function, and cadaveric kidney transplant.

Conclusion

The incidence of post-transplant UTI is similar in both developed and developing countries. E.coli is the most common pathogen in most of studies. Cadaveric donor and post-dialysis transplantation are defined as independent risk factors for post-transplant UTI. Further studies are still required to identify risk factors after kidney transplantation and UTI’s importance for graft function and patient outcome.

Levin A (2018) Improving global kidney health: international society of nephrology initiatives and the global kidney health atlas. Ann Nutr Metab 72(Suppl 2):28–32. https://doi.org/10.1159/000488123CrossRef

Luxardo R, Kramer A, Gonzalez-Bedat MC, Massy ZA, Jager KJ, Rosa-Diez G, Noordzij M, Collaborators (2018) The epidemiology of renal replacement therapy in two different parts of the world: the Latin American Dialysis and Transplant Registry versus the European Renal Association-European Dialysis and Transplant Association Registry. Rev Panam Salud Publ 42:e87. https://doi.org/10.26633/RPSP.2018.87CrossRef

Maglakelidze N, Pantsulaia T, Tchokhonelidze I, Managadze L, Chkhotua A (2011) Assessment of health-related quality of life in renal transplant recipients and dialysis patients. Transpl Proc 43(1):376–379. https://doi.org/10.1016/j.transproceed.2010.12.015CrossRef

Sanchez-Escuredo A, Alsina A, Diekmann F, Revuelta I, Esforzado N, Ricart MJ, Cofan F, Torregrosa JV, Campistol JM, Oppenheimer F, Fernandez E (2015) Economic analysis of the treatment of end-stage renal disease treatment: living-donor kidney transplantation versus hemodialysis. Transpl Proc 47(1):30–33. https://doi.org/10.1016/j.transproceed.2014.12.005CrossRef

Hollyer I, Ison MG (2018) The challenge of urinary tract infections in renal transplant recipients. Transpl Infect Dis 20(2):e12828. https://doi.org/10.1111/tid.12828CrossRef

Kauffman H, Rosendale J, Taranto S, McBride M, Marks W (2007) Non-heart-beating donors (then) and donation after cardiac death (now). Transpl Rev 21:237–248. https://doi.org/10.1016/j.trre.2007.01.007CrossRef

Al Midani A, Elands S, Collier S, Harber M, Shendi AM (2018) Impact of urinary tract infections in kidney transplant recipients: a 4-year single-center experience. Transpl Proc 50(10):3351–3355. https://doi.org/10.1016/j.transproceed.2018.08.022CrossRef

Olenski S, Scuderi C, Choo A, Bhagat Singh AK, Way M, Jeyaseelan L, John G (2019) Urinary tract infections in renal transplant recipients at a quaternary care centre in Australia. BMC Nephrol 20(1):479. https://doi.org/10.1186/s12882-019-1666-6CrossRef

Kotagiri P, Chembolli D, Ryan J, Hughes PD, Toussaint ND (2017) Urinary tract infections in the first year post-kidney transplantation: potential benefits of treating asymptomatic bacteriuria. Transpl Proc 49(9):2070–2075. https://doi.org/10.1016/j.transproceed.2017.07.008CrossRef

10.

Cowan J, Bennett A, Fergusson N, McLean C, Mallick R, Cameron DW, Knoll G (2018) Incidence rate of post-kidney transplant infection: a retrospective cohort study examining infection rates at a large Canadian multicenter tertiary-care facility. Can J Kidney Health Dis 5:2054358118799692. https://doi.org/10.1177/2054358118799692CrossRef

11.

Chuang P, Parikh CR, Langone A (2005) Urinary tract infections after renal transplantation: a retrospective review at two US transplant centers. Clin Transpl 19(2):230–235. https://doi.org/10.1111/j.1399-0012.2005.00327.xCrossRef

12.

Britt NS, Hagopian JC, Brennan DC, Pottebaum AA, Santos CAQ, Gharabagi A, Horwedel TA (2017) Effects of recurrent urinary tract infections on graft and patient outcomes after kidney transplantation. Nephrol Dial Transpl 32(10):1758–1766. https://doi.org/10.1093/ndt/gfx237CrossRef

13.

Alangaden GJ, Thyagarajan R, Gruber SA, Morawski K, Garnick J, El-Amm JM, West MS, Sillix DH, Chandrasekar PH, Haririan A (2006) Infectious complications after kidney transplantation: current epidemiology and associated risk factors. Clin Transpl 20(4):401–409. https://doi.org/10.1111/j.1399-0012.2006.00519.xCrossRef

14.

Lee JR, Bang H, Dadhania D, Hartono C, Aull MJ, Satlin M, August P, Suthanthiran M, Muthukumar T (2013) Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection: a single-center report of 1166 kidney allograft recipients. Transplantation 96(8):732–738. https://doi.org/10.1097/TP.0b013e3182a04997CrossRef

15.

Sorto R, Irizar SS, Delgadillo G, Alberu J, Correa-Rotter R, Morales-Buenrostro LE (2010) Risk factors for urinary tract infections during the first year after kidney transplantation. Transpl Proc 42(1):280–281. https://doi.org/10.1016/j.transproceed.2009.11.029CrossRef

16.

Rivera-Sanchez R, Delgado-Ochoa D, Flores-Paz RR, Garcia-Jimenez EE, Espinosa-Hernandez R, Bazan-Borges AA, Arriaga-Alba M (2010) Prospective study of urinary tract infection surveillance after kidney transplantation. BMC Infect Dis 10:245. https://doi.org/10.1186/1471-2334-10-245CrossRef

17.

Camargo LF, Esteves AB, Ulisses LR, Rivelli GG, Mazzali M (2014) Urinary tract infection in renal transplant recipients: incidence, risk factors, and impact on graft function. Transpl Proc 46(6):1757–1759. https://doi.org/10.1016/j.transproceed.2014.05.006CrossRef

18.

Pinheiro HS, Mituiassu AM, Carminatti M, Braga AM, Bastos MG (2010) Urinary tract infection caused by extended-spectrum beta-lactamase-producing bacteria in kidney transplant patients. Transpl Proc 42(2):486–487. https://doi.org/10.1016/j.transproceed.2010.02.002CrossRef

19.

Golebiewska J, Debska-Slizien A, Komarnicka J, Samet A, Rutkowski B (2011) Urinary tract infections in renal transplant recipients. Transpl Proc 43(8):2985–2990. https://doi.org/10.1016/j.transproceed.2011.07.010CrossRef

20.

Golebiewska JE, Debska-Slizien A, Rutkowski B (2014) Urinary tract infections during the first year after renal transplantation: one center's experience and a review of the literature. Clin Transpl 28(11):1263–1270. https://doi.org/10.1111/ctr.12465CrossRef

21.

Valera B, Gentil MA, Cabello V, Fijo J, Cordero E, Cisneros JM (2006) Epidemiology of urinary infections in renal transplant recipients. Transpl Proc 38(8):2414–2415. https://doi.org/10.1016/j.transproceed.2006.08.018CrossRef

22.

Bodro M, Sanclemente G, Lipperheide I, Allali M, Marco F, Bosch J, Cofan F, Ricart MJ, Esforzado N, Oppenheimer F, Moreno A, Cervera C (2015) Impact of urinary tract infections on short-term kidney graft outcome. Clin Microbiol Infect 21(12):1104 e1101–1104 e1108. https://doi.org/10.1016/j.cmi.2015.07.019CrossRef

23.

Galindo Sacristan P, Perez Marfil A, Osorio Moratalla JM, de Gracia GC, Ruiz Fuentes C, Castilla Barbosa YA, Garcia Jimenez B, de Teresa AJ, Barroso Martin FJ, Osuna Ortega A (2013) Predictive factors of infection in the first year after kidney transplantation. Transpl Proc 45(10):3620–3623. https://doi.org/10.1016/j.transproceed.2013.11.009CrossRef

24.

Pelle G, Vimont S, Levy PP, Hertig A, Ouali N, Chassin C, Arlet G, Rondeau E, Vandewalle A (2007) Acute pyelonephritis represents a risk factor impairing long-term kidney graft function. Am J Transpl 7(4):899–907. https://doi.org/10.1111/j.1600-6143.2006.01700.xCrossRef

25.

Ooms L, Ij J, Voor In 't Holt A, Betjes M, Vos M, Terkivatan T (2017) Urinary tract infections after kidney transplantation: a risk factor analysis of 417 patients. Ann Transpl 22:402–408. https://doi.org/10.12659/aot.903249CrossRef

26.

Memikoglu KO, Keven K, Sengul S, Soypacaci Z, Erturk S, Erbay B (2007) Urinary tract infections following renal transplantation: a single-center experience. Transpl Proc 39(10):3131–3134. https://doi.org/10.1016/j.transproceed.2007.10.005CrossRef

27.

Yabanoglu H, Aliskan HE, Caliskan K, Arer I, Akdur A, Yildirim S, Moray G, Haberal M (2015) Early infections in renal transplant recipients: incidence, risk factors, and causative microorganisms. Exp Clin Transpl 13(Suppl 3):11–14. https://doi.org/10.6002/ect.tdtd2015.O9CrossRef

28.

Azap O, Togan T, Yesilkaya A, Arslan H, Haberal M (2013) Antimicrobial susceptibilities of uropathogen Escherichia coli in renal transplant recipients: dramatic increase in ciprofloxacin resistance. Transpl Proc 45(3):956–957. https://doi.org/10.1016/j.transproceed.2013.03.006CrossRef

29.

Papasotiriou M, Savvidaki E, Kalliakmani P, Papachristou E, Marangos M, Fokaefs E, Maroulis I, Karavias D, Goumenos DS (2011) Predisposing factors to the development of urinary tract infections in renal transplant recipients and the impact on the long-term graft function. Ren Fail 33(4):405–410. https://doi.org/10.3109/0886022X.2011.568137CrossRef

30.

Iqbal T, Naqvi R, Akhter SF (2010) Frequency of urinary tract infection in renal transplant recipients and effect on graft function. J Pak Med Assoc 60(10):826–829

31.

Shohab D, Khawaja A, Atif E, Jamil I, Ali I, Akhter S (2015) Frequency of occurrence of urinary tract infection in double j stented versus non-stented renal transplant recipients. Saudi J Kidney Dis Transpl 26(3):443–446. https://doi.org/10.4103/1319-2442.157298CrossRef

32.

Kumar A, Agarwal C, Hooda AK, Ojha A, Dhillon M, Hari Kumar KV (2016) Profile of infections in renal transplant recipients from India. J Fam Med Prim Care 5(3):611–614. https://doi.org/10.4103/2249-4863.197320CrossRef

33.

Mukherjee D, Sharma S, Nair RK, Datt B, Arora D, Rao A (2018) Urinary tract infection in renal transplant recipients at a tertiary care center in India. Saudi J Kidney Dis Transpl 29(2):361–368. https://doi.org/10.4103/1319-2442.229294CrossRef

34.

Khanna P, Abraham G, Mohamed Ali AA, Miriam PE, Mathew M, Lalitha MK, Lesley N (2010) Urinary tract infections in the era of newer immunosuppressant agents: a tertiary care center study. Saudi J Kidney Dis Transpl 21(5):876–880

35.

Wu SW, Liu KS, Lin CK, Hung TW, Tsai HC, Chang HR, Lian JD (2013) Community-acquired urinary tract infection in kidney transplantation: risk factors for bacteremia and recurrent infection. J Form Med Assoc 112(3):138–143. https://doi.org/10.1016/j.jfma.2012.01.010CrossRef

36.

Khosravi AD, Abasi Montazeri E, Ghorbani A, Parhizgari N (2014) Bacterial urinary tract infection in renal transplant recipients and their antibiotic resistance pattern: a four-year study. Iran J Microbiol 6(2):74–78

37.

Mansury D, Khaledi A, Ghazvini K, Sabbagh MG, Zare H, Rokni-Hosseini MH, Vazini H (2018) Study of bacterial infections among patients receiving kidney transplant in Mashhad. Iran Exp Clin Transpl 16(3):282–286. https://doi.org/10.6002/ect.2016.0311CrossRef

38.

Shams SF, Eidgahi ES, Lotfi Z, Khaledi A, Shakeri S, Sheikhi M, Bahrami A (2017) Urinary tract infections in kidney transplant recipients 1(st) year after transplantation. J Res Med Sci 22:20. https://doi.org/10.4103/1735-1995.200274CrossRef

39.

Khedr EM, Attallah AHB, Shawki SM, Kamel CR (2012) Impact of urinary tract infection on the outcome of allograft renal transplantation in. J Am Sci 8:1

40.

Okafor UH (2016) Kidney transplant in Nigeria: a single centre experience. Pan Afr Med J 25:112. https://doi.org/10.11604/pamj.2016.25.112.7930CrossRef

41.

Gondos AS, Al-Moyed KA, Al-Robasi AB, Al-Shamahy HA, Alyousefi NA (2015) Urinary tract infection among renal transplant recipients in Yemen. PLoS ONE 10(12):e0144266. https://doi.org/10.1371/journal.pone.0144266CrossRef

42.

Alevizakos M, Nasioudis D, Mylonakis E (2017) Urinary tract infections caused by ESBL-producing Enterobacteriaceae in renal transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis 19:6. https://doi.org/10.1111/tid.12759CrossRef

43.

Wu X, Dong Y, Liu Y, Li Y, Sun Y, Wang J, Wang S (2016) The prevalence and predictive factors of urinary tract infection in patients undergoing renal transplantation: a meta-analysis. Am J Infect Control 44(11):1261–1268. https://doi.org/10.1016/j.ajic.2016.04.222CrossRef

44.

Vidal E, Torre-Cisneros J, Blanes M, Montejo M, Cervera C, Aguado JM, Len O, Carratala J, Cordero E, Bou G, Munoz P, Ramos A, Gurgui M, Borrell N, Fortun J, Spanish Network for Research in Infectious D (2012) Bacterial urinary tract infection after solid organ transplantation in the RESITRA cohort. Transpl Infect Dis 14(6):595–603. https://doi.org/10.1111/j.1399-3062.2012.00744.xCrossRef

45.

Yalci A, Celebi ZK, Ozbas B, Sengezer OL, Unal H, Memikoglu KO, Sengul S, Tuzuner A, Keven K (2015) Evaluation of infectious complications in the first year after kidney transplantation. Transpl Proc 47(5):1429–1432. https://doi.org/10.1016/j.transproceed.2015.04.056CrossRef

46.

Mohan M, Neeraja M, Sudhaharan S, Raju SB, Gangadhar T, Lakshmi V (2017) Risk factors for urinary tract infections in renal allograft recipients: experience of a tertiary care center in Hyderabad, South India. Indian J Nephrol 27(5):372–376. https://doi.org/10.4103/ijn.IJN_331_16CrossRef

47.

Fiorante S, Lopez-Medrano F, Lizasoain M, Lalueza A, Juan RS, Andres A, Otero JR, Morales JM, Aguado JM (2010) Systematic screening and treatment of asymptomatic bacteriuria in renal transplant recipients. Kidney Int 78(8):774–781. https://doi.org/10.1038/ki.2010.286CrossRef

48.

Gozdowska J, Czerwinska M, Chabros L, Mlynarczyk G, Kwiatkowski A, Chmura A, Durlik M (2016) Urinary tract infections in kidney transplant recipients hospitalized at a transplantation and nephrology ward: 1-year follow-up. Transpl Proc 48(5):1580–1589. https://doi.org/10.1016/j.transproceed.2016.01.061CrossRef

49.

Kosmadakis G, Daikos GL, Pavlopoulou ID, Gobou A, Kostakis A, Tzanatou-Exarchou H, Boletis JN (2013) Infectious complications in the first year post renal transplantation. Transplant Proc 45(4):1579–1583. https://doi.org/10.1016/j.transproceed.2012.10.047CrossRef

50.

Ness D, Olsburgh J (2019) UTI in kidney transplant. World J Urol. https://doi.org/10.1007/s00345-019-02742-6CrossRef

51.

Giessing M (2012) Urinary tract infection in renal transplantation. Arab J Urol 10(2):162–168. https://doi.org/10.1016/j.aju.2012.01.005CrossRef

52.

Origuen J, Fernandez-Ruiz M, Lopez-Medrano F, Ruiz-Merlo T, Gonzalez E, Morales JM, Fiorante S, San-Juan R, Villa J, Orellana MA, Andres A, Aguado JM (2016) Progressive increase of resistance in Enterobacteriaceae urinary isolates from kidney transplant recipients over the past decade: narrowing of the therapeutic options. Transpl Infect Dis 18(4):575–584. https://doi.org/10.1111/tid.12547CrossRef

53.

Green H, Rahamimov R, Goldberg E, Leibovici L, Gafter U, Bishara J, Mor E, Paul M (2013) Consequences of treated versus untreated asymptomatic bacteriuria in the first year following kidney transplantation: retrospective observational study. Eur J Clin Microbiol Infect Dis 32(1):127–131. https://doi.org/10.1007/s10096-012-1727-2CrossRef

54.

El Amari EB, Hadaya K, Buhler L, Berney T, Rohner P, Martin PY, Mentha G, van Delden C (2011) Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients. Nephrol Dial Transpl 26(12):4109–4114. https://doi.org/10.1093/ndt/gfr198CrossRef

55.

Fiorentino M, Pesce F, Schena A, Simone S, Castellano G, Gesualdo L (2019) Updates on urinary tract infections in kidney transplantation. J Nephrol. https://doi.org/10.1007/s40620-019-00585-3CrossRef

56.

Parasuraman R, Julian K, Practice ASTIDCo (2013) Urinary tract infections in solid organ transplantation. Am J Transpl 13(Suppl 4):327–336. https://doi.org/10.1111/ajt.12124CrossRef

57.

Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Koves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R (2019) Clinical practice guideline for the management of asymptomatic bacteriuria: 2019 update by the infectious diseases society of America. Clin Infect Dis. https://doi.org/10.1093/cid/ciy1121CrossRef

58.

Shendi AM, Wallis G, Painter H, Harber M, Collier S (2018) Epidemiology and impact of bloodstream infections among kidney transplant recipients: a retrospective single-center experience. Transpl Infect Dis 20:1. https://doi.org/10.1111/tid.12815CrossRef

59.

Green H, Rahamimov R, Gafter U, Leibovitci L, Paul M (2011) Antibiotic prophylaxis for urinary tract infections in renal transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis 13(5):441–447. https://doi.org/10.1111/j.1399-3062.2011.00644.xCrossRef

60.

European Centre for Disease Prevention and Control (2017) Surveillance of antimicrobial resistance in Europe 2017. https://ecdc.europa.eu/en/publications-data/surveillance-antimicrobial-resistance-europe-2017

61.

Zanichelli V, Huttner A, Harbarth S, Kronenberg A, Huttner B, Swiss Centre For Antibiotic Resistance A (2019) Antimicrobial resistance trends in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis urinary isolates from Switzerland: retrospective analysis of data from a national surveillance network over an 8-year period (2009–2016). Swiss Med Wkly 149:w20110. https://doi.org/10.4414/smw.2019.20110CrossRef

62.

Hsueh PR, Hoban DJ, Carmeli Y, Chen SY, Desikan S, Alejandria M, Ko WC, Binh TQ (2011) Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia–Pacific region. J Infect 63(2):114–123. https://doi.org/10.1016/j.jinf.2011.05.015CrossRef

63.

Reed TAN, Krang S, Miliya T, Townell N, Letchford J, Bun S, Sar B, Osbjer K, Seng S, Chou M, By Y, Vanchinsuren L, Nov V, Chau D, Phe T, de Lauzanne A, Ly S, Turner P, Cambodia Technical Working Group on Antimicrobial R (2019) Antimicrobial resistance in Cambodia: a review. Int J Infect Dis 85:98–107. https://doi.org/10.1016/j.ijid.2019.05.036CrossRef

64.

Karlowsky JA, Lagace-Wiens PR, Simner PJ, DeCorby MR, Adam HJ, Walkty A, Hoban DJ, Zhanel GG (2011) Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study. Antimicrob Agents Chemother 55(7):3169–3175. https://doi.org/10.1128/AAC.00066-11CrossRef

65.

Arredondo-Garcia JL, Amabile-Cuevas CF (2008) High resistance prevalence towards ampicillin, co-trimoxazole and ciprofloxacin, among uropathogenic Escherichia coli isolates in Mexico City. J Infect Dev Ctries 2(5):350–353

66.

Freire MP, Mendes CV, Piovesan AC, de Paula FJ, Spadao F, Nahas WC, David-Neto E, Pierrotti LC (2018) Does the urinary tract infection caused by carbapenem-resistant Gram-negative bacilli impact the outcome of kidney transplant recipients? Transpl Infect Dis 20(4):e12923. https://doi.org/10.1111/tid.12923CrossRef

67.

Molton JS, Tambyah PA, Ang BS, Ling ML, Fisher DA (2013) The global spread of healthcare-associated multidrug-resistant bacteria: a perspective from Asia. Clin Infect Dis 56(9):1310–1318. https://doi.org/10.1093/cid/cit020CrossRef

68.

Eleftheriadis T, Liakopoulos V, Leivaditis K, Antoniadi G, Stefanidis I (2011) Infections in hemodialysis: a concise review—Part 1: bacteremia and respiratory infections. Hippokratia 15(1):12–17

69.

Simforoosh N, Basiri A, Pourrezagholi F, et al. (2003) Is preemptive renal transplantation preferred? In: Paper presented at the transplantation proceeding

70.

Kroth LV, Barreiro FF, Saitovitch D, Traesel MA, d'Avila DO, Poli-de-Figueiredo CE (2016) Acute graft pyelonephritis occurring up to 30 days after kidney transplantation: epidemiology, risk factors, and survival. Transpl Proc 48(7):2298–2300. https://doi.org/10.1016/j.transproceed.2016.06.016CrossRef

71.

Rice JC, Safdar N, Practice ASTIDCo (2009) Urinary tract infections in solid organ transplant recipients. Am J Transpl 9(Suppl 4):S267–272. https://doi.org/10.1111/j.1600-6143.2009.02919.xCrossRef

72.

Dharnidharka VR, Agodoa LY, Abbott KC (2007) Risk factors for hospitalization for bacterial or viral infection in renal transplant recipients—an analysis of USRDS data. Am J Transpl 7(3):653–661. https://doi.org/10.1111/j.1600-6143.2006.01674.xCrossRef

73.

Snyder JJ, Israni AK, Peng Y, Zhang L, Simon TA, Kasiske BL (2009) Rates of first infection following kidney transplant in the United States. Kidney Int 75(3):317–326. https://doi.org/10.1038/ki.2008.580CrossRef

74.

de Souza RM, Olsburgh J (2008) Urinary tract infection in the renal transplant patient. Nat Clin Pract Nephrol 4(5):252–264. https://doi.org/10.1038/ncpneph0781CrossRef

75.

Fishman JA, Rubin RH (1998) Infection in organ-transplant recipients. N Engl J Med 338(24):1741–1751. https://doi.org/10.1056/NEJM199806113382407CrossRef

76.

Khoury JA, Brennan DC (2005) Infectious complications in kidney transplant recipients: review of the literature. Saudi J Kidney Dis Transpl 16(4):453–497

77.

Taminato M, Fram D, Grothe C, Pereira RR, Belasco A, Barbosa D (2015) Prevalence of infection in kidney transplantation from living versus deceased donor: systematic review and meta-analysis. Rev Esc Enferm USP 49(3):509–514. https://doi.org/10.1590/S0080-623420150000300020CrossRef

78.

Sousa SR, Galante NZ, Barbosa DA, Pestana JO (2010) Incidence of infectious complications and their risk factors in the first year after renal transplantation. J Bras Nefrol 32(1):75–82CrossRef

Titel: Five compelling UTI questions after kidney transplant
verfasst von: Selda Aydın
Abhijit Patil
Mahesh Desai
Nasser Simforoosh
Publikationsdatum: 07.04.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 11/2020
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03173-4

Neu im Fachgebiet Urologie

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

Stufenschema weist Prostatakarzinom zuverlässig nach

22.04.2024 Prostatakarzinom Nachrichten

Erst PSA-Test, dann Kallikrein-Score, schließlich MRT und Biopsie – ein vierstufiges Screening-Schema kann die Zahl der unnötigen Prostatabiopsien erheblich reduzieren: Die Hälfte der Männer, die in einer finnischen Studie eine Biopsie benötigten, hatte einen hochgradigen Tumor.

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

20.04.2024 EAU 2024 Kongressbericht

Beim chronischen Harnwegsinfekt bei Frauen wird bisher meist eine Antibiotikaprophylaxe eingesetzt. Angesichts der zunehmenden Antibiotikaresistenz erweist sich das Antiseptikum Methenamin-Hippurat als vielversprechende Alternative, so die Auswertung einer randomisierten kontrollierten Studie.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2020

Perioperative antithrombotic (antiplatelet and anticoagulant) therapy in urological practice: a critical assessment and summary of the clinical practice guidelines

Substantial radiation dose reduction with consistent image quality using a novel low-dose stone composition protocol

The LACE + index as a predictor of 90-day urologic surgery outcomes

The impact of extended pelvic lymph node dissection on the risk of hospital readmission within 180 days after robot assisted radical prostatectomy