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01.10.2008 | Natural Medicine Note

Free-radical-scavenging principles from Phlomis caucasica

verfasst von: Abbas Delazar, Araz Sabzevari, Mahdi Mojarrab, Hossein Nazemiyeh, Solmaz Esnaashari, Lutfun Nahar, Seied Mehdi Razavi, Satyajit Dey Sarker

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2008

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Abstract

Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (1), chrysoeriol 7-O-rutinoside (2), kaempferol 3-O-glucoside (3), chrysoeriol 7-O-glucoside (4) and naringenin (5), and two phenylethanoid glycosides, forsythoside B (6) and acteoside (7) were isolated from the methanol extract of the aerial parts of the Iranian medicinal plant Phlomis caucasica by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of 1–7 were assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. Among these compounds, forsythoside B (6) and acteoside (7) were found to be the most potent antioxidants with the RC₅₀ values of 4.97 and 4.27 μg/ml, respectively.

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Titel: Free-radical-scavenging principles from Phlomis caucasica
verfasst von: Abbas Delazar
Araz Sabzevari
Mahdi Mojarrab
Hossein Nazemiyeh
Solmaz Esnaashari
Lutfun Nahar
Seied Mehdi Razavi
Satyajit Dey Sarker
Publikationsdatum: 01.10.2008
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2008
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-008-0255-y

Springer Medizin

Abstract

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