Skip to main content
Erschienen in: Clinical & Experimental Metastasis 5-6/2018

04.08.2018 | Review

Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves

verfasst von: Russell S. Witte, Chandra Karunakaran, Andres N. Zuniga, Hannah Schmitz, Hina Arif

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 5-6/2018

Einloggen, um Zugang zu erhalten

Abstract

This review describes emerging techniques within the last 5 years that employ ultrasound for detecting and staging malignancy, tracking metastasis, and guiding treatment. Ultrasound elastography quantifies soft tissue elastic properties that change as a tumor grows and proliferates. Hybrid imaging modalities that combine ultrasound with light or microwave energy provide novel contrast for mapping blood oxygen saturation, transport of particles through lymphatic vessels and nodes, and real-time feedback for guiding needle biopsies. Combining these methods with smart nanoparticles and contrast agents further promotes new paradigms for cancer imaging and therapy.
Literatur
1.
Zurück zum Zitat Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C (2012) Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 31(2):281–287CrossRef Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C (2012) Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 31(2):281–287CrossRef
2.
Zurück zum Zitat Sayed A, Layne G, Abraham J, Mukdadi OM (2014) 3-D visualization and non-linear tissue classification of breast tumors using ultrasound elastography in vivo. Ultrasound Med Biol 40(7):1490–1502CrossRef Sayed A, Layne G, Abraham J, Mukdadi OM (2014) 3-D visualization and non-linear tissue classification of breast tumors using ultrasound elastography in vivo. Ultrasound Med Biol 40(7):1490–1502CrossRef
3.
Zurück zum Zitat Yang Y, Xu X, Guo L, He Y, Wang D, Liu B, Zhao C, Chen B, Xu H (2017) Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions. Sci Rep 7:40964CrossRef Yang Y, Xu X, Guo L, He Y, Wang D, Liu B, Zhao C, Chen B, Xu H (2017) Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions. Sci Rep 7:40964CrossRef
4.
Zurück zum Zitat Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 71(2):452–456CrossRef Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 71(2):452–456CrossRef
5.
Zurück zum Zitat Ho F, Tham IW, Earnest A, Lee KM, Lu JJ (2012) Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12:98CrossRef Ho F, Tham IW, Earnest A, Lee KM, Lu JJ (2012) Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12:98CrossRef
6.
Zurück zum Zitat Azizi G, Keller JM, Mayo ML, Piper K, Puett D, Earp KM, Malchoff CD (2016) Shear wave elastography and cervical lymph nodes: predicting malignancy. Ultrasound Med Biol 42(6):1273–1281CrossRef Azizi G, Keller JM, Mayo ML, Piper K, Puett D, Earp KM, Malchoff CD (2016) Shear wave elastography and cervical lymph nodes: predicting malignancy. Ultrasound Med Biol 42(6):1273–1281CrossRef
7.
Zurück zum Zitat Chen BB, Li J, Guan Y, Xiao WW, Zhao C, Lu TX, Han F (2018) The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: a preliminary study. Eur J Radiol 103:19–24CrossRef Chen BB, Li J, Guan Y, Xiao WW, Zhao C, Lu TX, Han F (2018) The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: a preliminary study. Eur J Radiol 103:19–24CrossRef
8.
Zurück zum Zitat Ting CE, Yeong CH, Ng KH, Abdulla BJJ, Ting HE (2015) Accuracy of tissue elasticity measurement using shear wave ultrasound elastography: a comparative phantom study. In: World congress on medical physics and biomedical engineering. Springer, Toronto, pp 252–255 Ting CE, Yeong CH, Ng KH, Abdulla BJJ, Ting HE (2015) Accuracy of tissue elasticity measurement using shear wave ultrasound elastography: a comparative phantom study. In: World congress on medical physics and biomedical engineering. Springer, Toronto, pp 252–255
9.
Zurück zum Zitat Menezes GLG, Pijnappel RM, Meeuwis C, Bisschops R, Veltman J, Lavin PT, van de Vijver MJ, Mann RM (2018) Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging. Radiology 17:170500 Menezes GLG, Pijnappel RM, Meeuwis C, Bisschops R, Veltman J, Lavin PT, van de Vijver MJ, Mann RM (2018) Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging. Radiology 17:170500
10.
Zurück zum Zitat Lin L, Hu P, Shi J, Appleton CM, Maslov K, Li L, Zhang R, Wang LV (2018) Single-breath-hold photoacoustic computed tomography of the breast. Nat Commun 9(1):2352CrossRef Lin L, Hu P, Shi J, Appleton CM, Maslov K, Li L, Zhang R, Wang LV (2018) Single-breath-hold photoacoustic computed tomography of the breast. Nat Commun 9(1):2352CrossRef
11.
Zurück zum Zitat Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV (2015) Dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection in patients with breast cancer. Sci Rep 5:15748CrossRef Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV (2015) Dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection in patients with breast cancer. Sci Rep 5:15748CrossRef
12.
Zurück zum Zitat Forbrich A, Heinmiller A, Zemp RJ (2017) Photoacoustic imaging of lymphatic pumping. J Biomed Opt 22(10):106003CrossRef Forbrich A, Heinmiller A, Zemp RJ (2017) Photoacoustic imaging of lymphatic pumping. J Biomed Opt 22(10):106003CrossRef
13.
Zurück zum Zitat Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J (2015) Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 7(317):317ra199CrossRef Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J (2015) Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 7(317):317ra199CrossRef
14.
Zurück zum Zitat Luke GP, Myers JN, Emelianov SY, Sokolov KV (2014) Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors. Cancer Res 74(19):5397–5408CrossRef Luke GP, Myers JN, Emelianov SY, Sokolov KV (2014) Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors. Cancer Res 74(19):5397–5408CrossRef
15.
Zurück zum Zitat Yang L, Cheng J, Chen Y, Yu S, Liu F, Sun Y, Chen Y, Ran H (2017) Phase-transition nanodroplets for real-time photoacoustic/ultrasound dual-modality imaging and photothermal therapy of sentinel lymph node in breast cancer. Sci Rep 7:45213CrossRef Yang L, Cheng J, Chen Y, Yu S, Liu F, Sun Y, Chen Y, Ran H (2017) Phase-transition nanodroplets for real-time photoacoustic/ultrasound dual-modality imaging and photothermal therapy of sentinel lymph node in breast cancer. Sci Rep 7:45213CrossRef
16.
Zurück zum Zitat Kruger RA, Miller KD, Reynolds HE, Kiser WL, Reinecke DR, Kruger GA (2000) Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz—feasibility study. Radiology 216(1):279–283CrossRef Kruger RA, Miller KD, Reynolds HE, Kiser WL, Reinecke DR, Kruger GA (2000) Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz—feasibility study. Radiology 216(1):279–283CrossRef
17.
Zurück zum Zitat Razansky D, Kellnberger S, Ntziachristos V (2010) Near-field radiofrequency thermoacoustic tomography with impulse excitation. Med Phys 37(9):4602–4607CrossRef Razansky D, Kellnberger S, Ntziachristos V (2010) Near-field radiofrequency thermoacoustic tomography with impulse excitation. Med Phys 37(9):4602–4607CrossRef
18.
Zurück zum Zitat Lou C, Yang S, Ji Z, Chen Q, Xing D (2012) Ultrashort microwave-induced thermoacoustic imaging: a breakthrough in excitation efficiency and spatial resolution. Phys Rev Lett 109:218101 Lou C, Yang S, Ji Z, Chen Q, Xing D (2012) Ultrashort microwave-induced thermoacoustic imaging: a breakthrough in excitation efficiency and spatial resolution. Phys Rev Lett 109:218101
19.
Zurück zum Zitat Ye F, Ji Z, Ding W, Lou C, Yang S, Xing D (2016) Ultrashort microwave-pumped real-time thermoacoustic breast tumor imaging system. IEEE Trans Med Imaging 35(3):839–844CrossRef Ye F, Ji Z, Ding W, Lou C, Yang S, Xing D (2016) Ultrashort microwave-pumped real-time thermoacoustic breast tumor imaging system. IEEE Trans Med Imaging 35(3):839–844CrossRef
20.
Zurück zum Zitat Wen L, Yang S, Zhong J, Zhou Q, Xing D (2017) Thermoacoustic imaging and therapy guidance based on ultra short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles. Theranostics 7(7):1976–1989CrossRef Wen L, Yang S, Zhong J, Zhou Q, Xing D (2017) Thermoacoustic imaging and therapy guidance based on ultra short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles. Theranostics 7(7):1976–1989CrossRef
Metadaten
Titel
Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves
verfasst von
Russell S. Witte
Chandra Karunakaran
Andres N. Zuniga
Hannah Schmitz
Hina Arif
Publikationsdatum
04.08.2018
Verlag
Springer Netherlands
Erschienen in
Clinical & Experimental Metastasis / Ausgabe 5-6/2018
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-018-9923-9

Weitere Artikel der Ausgabe 5-6/2018

Clinical & Experimental Metastasis 5-6/2018 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.