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Erschienen in: Journal of Ophthalmic Inflammation and Infection 1/2016

Open Access 01.12.2016 | Brief report

Fulminant proliferative vitreoretinopathy in syphilitic uveitis

verfasst von: Rafael de Pinho Queiroz, André Vasconcelos Diniz, Daniel Vitor Vasconcelos-Santos

Erschienen in: Journal of Ophthalmic Inflammation and Infection | Ausgabe 1/2016

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Abstract

Background

Syphilis is a reemerging sexually transmitted disease that can lead to any type of intraocular inflammation. Prognosis of syphilitic uveitis after appropriate therapy is classically regarded as favorable. However, visual threatening complications may develop, rarely including rhegmatogenous/tractional retinal detachment (R/T RD) and proliferative vitreoretinopathy.

Findings

We report 4 patients presenting with complex R/T RD and fulminant proliferative vitreoretinopathy despite treatment among 19 patients with syphilitic posterior uveitis consecutively seen at our uveitis service. Most of these complications occurred during or shortly after antibiotic therapy. All patients presented with significant intraocular inflammation, including vitritis, occlusive retinal vasculitis, and retinal infiltrates (necrotizing retinochoroiditis in six eyes of four patients). Two patients (50 %) tested HIV positive, and the same proportion had inadvertently received high dose oral ± intravenous corticosteroids prior to diagnosis of syphilis. Two patients (three eyes) underwent RD surgical repair. Histopathology of an excised epiretinal membrane disclosed fibroglial tissue, with immature glial cells and metaplastic retinal pigment epithelium, admixed with lymphoplasmacytic infiltrate.

Conclusions

Syphilitic uveitis may be complicated by complex RD/fulminant fibroglial proliferation, occurring during/after treatment. Predisposing factors are currently unknown but may include prior use of corticosteroid, necrotizing retinitis and/or high spirochaetal load. A significant inflammatory component may underlie this fulminant fibroglial proliferation, being possibly amenable to modulation by aggressive anti-inflammatory therapy delivered concurrently with parenteral antibiotics.
Hinweise
Presented in part at the Fall Meeting of the American Uveitis Society, Chicago, November 11th 2012
No related papers from this same study were previously published or are under appreciation elsewhere.

Competing interests

All authors declare no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work.

Authors’ contributions

RQ made contributions on the design, acquisition, analysis, and interpretation of data; drafting and revising of the article; and approval of the final version. AD made contributions on the acquisition and analysis of data, revising of the article; and approval of the final version. DV-S made contributions on the conception and design, acquisition, analysis, and interpretation of data; revision of the article; and final approval.
Abkürzungen
AC
anterior chamber
AIDS
acquired immunodeficiency syndrome
BCVA
best-corrected visual acuity
CF
counting fingers
ERM
epiretinal membrane
HM
hand movements
IOP
intraocular pressure
IV
intravenous
OD
right eye
OS
left eye
OU
both eyes
PPV
pars plana vitrectomy
PRI
punctate inner retinal infiltrates
PVD
posterior vitreous detachment
R/T RD
rhegmatogenous/tractional retinal detachment

Findings

Syphilis has been reemerging globally, particularly in association with acquired immunodeficiency syndrome (AIDS) and with contemporary changes in sexual practices [1]. The prevalence of syphilitic uveitis parallels this rise on the general incidence of the disease, with novel ocular manifestations, such as inner punctate retinitis, being recently described [2]. The prognosis has been classically regarded as favorable, with good response to parenteral penicillin [14].
From April 2011 to October 2012, we had 19 consecutive patients with syphilitic posterior uveitis admitted to our referral hospital, of which 4 (21.05 %) presented with rhegmatogenous/tractional retinal detachment (R/T RD) and fulminant proliferative vitreoretinopathy (PVR) during or shortly after parenteral penicillin therapy.

Report of cases

Case 1

A 24-year-old male reported decreased vision in both eyes, worse in the left (OS), for 8 weeks. Best-corrected visual acuity (BCVA) on admission was 20/63 in the right eye (OD) and hand movements (HM) in OS. Biomicroscopy showed 0.5+ anterior chamber (AC) cells in OD and 2+ AC cells in OS, with 2+ vitreous cells bilaterally. Intraocular pressure (IOP) was within normal limits. Fundus examination revealed 1+ vitreous haze in both eyes (OU). Punctate inner retinal infiltrates (PRI) in the temporal periphery of OD and nasally in OS were also seen, in addition to a large necrotizing lesion involving the inferior aspect of the left retina.
In the face of positive syphilis serology (Table 1), he was admitted and treated with intravenous (IV) penicillin (4 million IU q4h). Oral prednisone 60 mg daily was added 3 days later, in a tapering regimen. Resolution of active intraocular inflammation was verified upon discharge. In the following week, BCVA improved to 20/40 in OD and 20/32 in OS.
Table 1
Aspects of four patients with syphilitic uveitis presenting with retinal detachment and fulminant fibroglial proliferation
Case
Initial BCVA
Laboratory results
Presentation of posterior uveitis
Duration of treatment
Outcome after treatmenta
Final BCVA
Case 1
OD: 20/63
Serum: + VDRL: 1/512 + TPHA
OD: PRI
Intravenous penicillin: 14 days
OD: Macular pucker (21 weeks)
OD: 20/63
OS: HM
CSF: + VDRL
Pleocytosis
HIV: negative
OS: PRI, NRC
Prednisone: 60 mg/day (tapering regimen for 7 weeks)
OS: Tractional RD (8 weeks)
OS: CF
Case 2
OD: HM
Serum: + VDRL: 1/1024 + TPHA
OD: NRC
Intravenous penicillin: 21 days
OD: Mixed RD (2 weeks)
OD: LP
OS: HM
CSF: + VDRL
Pleocytosis
HIV: positive
OS: NRC
Prednisone: 60 mg/day (tapering regimen for 7 weeks)
OS: Mixed RD (1 week)
OS: 20/150
Case 3
OD: CF
Serum: + VDRL:1/4096 + THPA
OD: NRC
Intravenous penicillin: 21 days
OD: Macular Pucker (5 weeks)
OD: 20/250
OS: HM
CSF: + VDRL
Pleocytosis
HIV: negative
OS: PPCR, PRI, NRC
Prednisone: 60 mg/day (tapering regimen for 10 weeks)
OS: Mixed RD (4 weeks)
OS: HM
Case 4
OD: HM
Serum: + VDRL: 1/512 + THPA
OD: NRC
Intravenous penicillin: 21 days
OD: Tractional RD (2 weeks)
OD: NLP
OS: 20/200
CSF: − VDRL
HIV: positive
OS: Optic disc hyperemia, vascular sheathing
Prednisone: 60 mg/day (tapering regimen for 4 weeks)
OS: No lesions
OS: 20/20
BCVA best corrected visual acuity, OD right eye, OS left eye, HM hand movements, VDRL Venereal Disease Research Laboratory, TPHA Treponema pallidum hemagglutination assay, CSF cerebrospinal fluid, HIV human immunodeficiency virus, PRI punctate inner retinal infiltrates, NRC necrotizing retinochoroiditis, RD retinal detachment CF, counting fingers, LP light perception PPCR, posterior placoid chorioretinitis, NPL no light perception
aThe time indicated in brackets refers to interval between initial diagnosis and moment that the complication occurred / was detected.
Five weeks later, he reported decreased vision in OS since the week prior. BCVA was 20/25 in OD and counting fingers (CF) in OS. Extensive R/T RD in the posterior pole of OS had developed, with subretinal fibrosis and marked epiretinal fibroglial proliferation (Fig 1). The patient refused surgery and RD rapidly progressed over the next few weeks. The contralateral eye retained good vision until 3 months later, when severe macular pucker was noted in OD (Fig. 1), reducing BCVA to 20/63 (Table 1).

Case 2

A 45-year-old male was referred with a history of decreased vision in OU for 2 months, despite topical, oral and IV steroids. On admission, BCVA was HM in OU. Biomicroscopy showed large granulomatous keratic precipitates, in addition to 2+ AC cells and 3+ vitreous cells. Fundus examination disclosed 4+ vitreous haze in OU, with dense vitritis and attached retinas on B-scan. Desquamative erythematous lesions of the palms and soles were also observed.
Uveitis workup revealed positive serology for syphilis and for HIV, with CD4+ cell count of 419/mL. The patient was treated for 21 days with IV penicillin, in combination with oral prednisone. Despite improvement of the vitreous haze in OU, R/T RD developed and rapidly progressed, with extensive PVR bilaterally. Pars plana vitrectomy (PPV) was performed in OU, with decreased vision despite attached retinas postoperatively (Table 1).

Case 3

A 57-year-old male complained of decreased vision for 30 days in OD, having been unsuccessfully treated for presumed toxoplasmic retinochoroiditis with oral sulfamethoxazole-trimethoprim and prednisone elsewhere. Three weeks later, symptoms started in OS. He also had desquamative erythematous lesions in the palms/soles for several weeks. On admission, BCVA was HM in OD and CF in OS. Biomicroscopy revealed vitreous cells in OU. Fundus examination was precluded because of dense vitreous haze in OD, but B-scan initially ruled out any RD, as well as posterior vitreous detachment (PVD). OS had macular and optic disc edema and PRI in the temporal periphery. Fluorescein angiogram of OS showed changes consistent with superimposed posterior placoid chorioretinitis, as well as multifocal occlusive arteritis.
After positive serology for syphilis (Table 1), the patient received IV penicillin for 21 days. A tapering regimen of prednisone was started 48 h later. Vitreous haze progressively improved thereafter, disclosing foci of retinal necrosis, associated with extensive occlusive vasculitis in OU.
Five days after discharge, R/T RD developed in OS. PPV was performed 6 days later. Partial PVD was noted during the procedure, but fulminant PVR had developed (Fig. 2). Histopathology of the excised epiretinal membrane (ERM) disclosed fibroglial proliferation, with immature glial cells and metaplastic retinal pigment epithelium, admixed with lymphoplasmacytic infiltrate. Numerous plasma cells could also be seen adhered to the internal limiting membrane (Fig. 3b, c). In 1 week, marked macular pucker developed in OD, rapidly progressing, and not responding to oral/periocular steroids (Fig. 2a, c).

Case 4

A 36-year-old HIV-positive male with CD4+ cell count of 80 cells/mL was referred to our facility complaining of decreased vision OU for 40 days. Biomicroscopy showed 2+ and 1+ AC cells in OD and OS respectively, with 2–3+ vitreous cells OU. Fundus examination of OD revealed 3+ vitreous haze; large necrotizing retinal lesions could also be partially seen inferiorly. OS showed optic disc hyperemia and peripheral vascular sheathing.
Workup revealed positive serology for syphilis (Table 1). IV aqueous penicillin was initiated, with addition of oral prednisone after 48 h. Intraocular inflammation progressively improved, but within 7 days of treatment, R/T RD developed in OD, leading to PVR and progression to no light perception before surgery could be performed. OS maintained good VA (Table 1).

Comments

Reports since early 2000s have been pointing to the reemergence of syphilis worldwide [1]. Syphilitic uveitis is reported in 2.5–5 % of cases of syphilis [5], manifesting as any type of intraocular inflammation. Despite the usual good prognosis following adequate treatment [1, 4], posterior syphilitic uveitis and panuveitis may potentially be complicated by RD. Eight cases (11 eyes) of patients with syphilitic uveitis presenting with this complication have been previously reported in indexed literature, mostly attributed to a predominant rhegmatogenous component, with variable PVR. Three of these 11 eyes (27.3 %) were left with BCVA ≤20/200 despite surgery [69]. We here report even worse outcomes in five eyes of four patients with syphilitic uveitis developing RD/fulminant fibroglial proliferation. Two patients also developed rapidly progressive macular pucker in the contralateral eye (Table 1). Most of these complications occurred during or shortly after antibiotic therapy, except for case 1, in which it surprisingly occurred subacutely, 5 weeks after discharge.
Common features were the presence of necrotizing retinal lesions, high VDRL titers (1:512 to 1:4096; in fact, higher than the majority of other patients) and delayed diagnosis. Nontreponemal antibody titers may indeed correlate with disease activity [10], and this might have been associated with more severe retinal damage in our cases. Characteristic skin lesions in two patients and high VDRL titers in all of them, suggesting high spirochaetal load, point to uveitis occurring at the secondary stage of syphilis. Prior use of corticosteroids and concomitant HIV infection (previously unrecognized in one patient) were probably other contributing factors [3, 11]. It has been demonstrated that corticosteroid-induced immunossupression allows for spirochaetal proliferation [12]. Two of the patients were HIV positive, with a CD4 count of 419 (case 2) and 80 (case 4), and two had received systemic corticosteroids before the diagnosis (Table 1). Another predisposing factor might have been younger age (three of four patients <45 years), possibly associated with incomplete PVD.
Interestingly, histopathology of excised fibroglial membrane disclosed an inflammatory infiltrate rich in plasma cells (Fig. 3), which may underlie the rapid fibroglial proliferation seen in our cases. This pattern is consistent with that seen in the histopathology of Jarisch-Herxheimer reaction following antibiotic therapy [13]. It is likely that such intraocular inflammation in our cases may have served as a trigger for PVR. Indeed, several growth factors (PDGF, FGF, TNF-α, TNF-β) and cytokines (IL-1, IL-6, IL-8, IL-10, INF-γ) are thought to play a role in PVR, mediating chemotaxis and cellular migration, cellular proliferation, membrane formation with remodeling of the extracellular matrix, and, finally, contraction (mediated by myofibroblasts) and subsequent tractional RD [14]. We hypothesize that this deleterious inflammatory response contributing to PVR may be amenable to early modulation by aggressive anti-inflammatory therapy, including higher doses of oral or even periocular costicosteroids.
In conclusion, syphilitic posterior uveitis may be associated with complex RD and fulminant PVR despite therapy, with a potentially poor visual prognosis. Contributing factors, such as delayed diagnosis and previous use of corticosteroids, might be addressed. On the other hand, use of corticosteroids after the initiation of antibiotics might be of benefit to better modulate the inflammatory process, likely associated with a local Jarisch-Herxheimer response.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Competing interests

All authors declare no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work.

Authors’ contributions

RQ made contributions on the design, acquisition, analysis, and interpretation of data; drafting and revising of the article; and approval of the final version. AD made contributions on the acquisition and analysis of data, revising of the article; and approval of the final version. DV-S made contributions on the conception and design, acquisition, analysis, and interpretation of data; revision of the article; and final approval.
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Metadaten
Titel
Fulminant proliferative vitreoretinopathy in syphilitic uveitis
verfasst von
Rafael de Pinho Queiroz
André Vasconcelos Diniz
Daniel Vitor Vasconcelos-Santos
Publikationsdatum
01.12.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Ophthalmic Inflammation and Infection / Ausgabe 1/2016
Elektronische ISSN: 1869-5760
DOI
https://doi.org/10.1186/s12348-016-0075-2

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