Skip to main content
Erschienen in: Neuroradiology 1/2018

21.11.2017 | Functional Neuroradiology

Functional brain networks involved in decision-making under certain and uncertain conditions

verfasst von: Danielle C. Farrar, Asim Z. Mian, Andrew E. Budson, Mark B. Moss, Ronald J. Killiany

Erschienen in: Neuroradiology | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim of this study was to describe imaging markers of decision-making under uncertain conditions in normal individuals, in order to provide baseline activity to compare to impaired decision-making in pathological states.

Methods

In this cross-sectional study, 19 healthy subjects ages 18–35 completed a novel decision-making card-matching task using a Phillips T3 Scanner and a 32-channel head coil. Functional data were collected in six functional runs. In one condition of the task, the participant was certain of the rule to apply to match the cards; in the other condition, the participant was uncertain. We performed cluster-based comparison of the two conditions using FSL fMRI Expert Analysis Tool and network-based analysis using MATLAB.

Results

The uncertain > certain comparison yielded three clusters—a midline cluster that extended through the midbrain, the thalamus, bilateral prefrontal cortex, the striatum, and bilateral parietal/occipital clusters. The certain > uncertain comparison yielded bilateral clusters in the insula, parietal and temporal lobe, as well as a medial frontal cluster. A larger, more connected functional network was found in the uncertain condition.

Conclusion

The involvement of the insula, parietal cortex, temporal cortex, ventromedial prefrontal cortex, and orbitofrontal cortex of the certain condition reinforces the notion that certainty is inherently rewarding. For the uncertain condition, the involvement of the prefrontal cortex, parietal cortex, striatum, thalamus, amygdala, and hippocampal involvement was expected, as these are areas involved in resolving uncertainty and rule updating. The involvement of occipital cortical involvement and midbrain involvement may be attributed to increased visual attention and increased motor control.
Literatur
7.
Zurück zum Zitat Krug A, Cabanis M, Pyka M, Pauly K, Walter H, Landsberg M, Shah NJ, Winterer G, Wölwer W, Musso F, Müller BW, Wiedemann G, Herrlich J, Schnell K, Vogeley K, Schilbach L, Langohr K, Rapp A, Klingberg S, Kircher T (2014) Investigation of decision-making under uncertainty in healthy subjects: a multi-centric fMRI study. Behav Brain Res 261:89–96. https://doi.org/10.1016/j.bbr.2013.12.013 CrossRefPubMed Krug A, Cabanis M, Pyka M, Pauly K, Walter H, Landsberg M, Shah NJ, Winterer G, Wölwer W, Musso F, Müller BW, Wiedemann G, Herrlich J, Schnell K, Vogeley K, Schilbach L, Langohr K, Rapp A, Klingberg S, Kircher T (2014) Investigation of decision-making under uncertainty in healthy subjects: a multi-centric fMRI study. Behav Brain Res 261:89–96. https://​doi.​org/​10.​1016/​j.​bbr.​2013.​12.​013 CrossRefPubMed
15.
Zurück zum Zitat Nieuwenhuys R, Voogd J, van Huijzen F.M.A.A. C (2008) The human central nervous system: Springer Berlin Heidelberg Nieuwenhuys R, Voogd J, van Huijzen F.M.A.A. C (2008) The human central nervous system: Springer Berlin Heidelberg
20.
Metadaten
Titel
Functional brain networks involved in decision-making under certain and uncertain conditions
verfasst von
Danielle C. Farrar
Asim Z. Mian
Andrew E. Budson
Mark B. Moss
Ronald J. Killiany
Publikationsdatum
21.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 1/2018
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-017-1949-1

Weitere Artikel der Ausgabe 1/2018

Neuroradiology 1/2018 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.