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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 6/2015

01.06.2015 | Miscellaneous

Fundus-controlled two-color dark adaptometry with the Microperimeter MP1

verfasst von: Wadim Bowl, Knut Stieger, Birgit Lorenz

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 6/2015

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Abstract

Purpose

The aim of this study was to provide fundus-controlled two-color adaptometry with an existing device. A quick and easy approach extends the application possibilities of a commercial fundus-controlled perimeter.

Methods

An external filter holder was placed in front the objective lens of the MP1 (Nidek, Italy) and fitted with filters to modify background, stimulus intensity, and color. Prior to dark adaptometry, the subject’s visual sensitivity profile was measured for red and blue stimuli to determine whether rods or cones or both mediated the absolute threshold. After light adaptation, 20 healthy subjects were investigated with a pattern covering six spots at the posterior pole of the retina up to 45 min of dark adaptation. Thresholds were determined using a 200 ms red Goldmann IV and a blue Goldmann II stimulus.

Results

The pre-test sensitivity showed a typical distribution of values along the meridian, with high peripheral light increment sensitivity (LIS) and low central LIS for rods and the reverse for cones. After bleach, threshold recovery had a classic biphasic shape. The absolute threshold was reached after approximately 10 min for the red and 15 min for the blue stimulus.

Conclusions

Two-color fundus-controlled adaptometry with a commercial MP1 without internal changes to the device provides a quick and easy examination of rod and cone function during dark adaptation at defined retinal loci of the posterior pole. This innovative method will be helpful to measure rod vs. cone function at known loci of the posterior pole in early stages of retinal degenerations.
Literatur
1.
Zurück zum Zitat Levin LA, Nilsson SFE, Ver Hoeve J, Wu S, Kaufman PL, Alm A (2011) Adler’s physiology of the eye, 11th edn. Saunders/Elsevier, Edinburgh Levin LA, Nilsson SFE, Ver Hoeve J, Wu S, Kaufman PL, Alm A (2011) Adler’s physiology of the eye, 11th edn. Saunders/Elsevier, Edinburgh
2.
Zurück zum Zitat Johnson CA, Keltner JL, Balestrery F (1978) Effects of target size and eccentricity on visual detection and resolution. Vis Res 18(9):1217–1222CrossRefPubMed Johnson CA, Keltner JL, Balestrery F (1978) Effects of target size and eccentricity on visual detection and resolution. Vis Res 18(9):1217–1222CrossRefPubMed
3.
Zurück zum Zitat Johnson CA, Keltner JL, Balestrery FG (1981) Static and acuity profile perimetry at various adaptation levels. Doc Ophthalmol 50(2):371–388CrossRefPubMed Johnson CA, Keltner JL, Balestrery FG (1981) Static and acuity profile perimetry at various adaptation levels. Doc Ophthalmol 50(2):371–388CrossRefPubMed
4.
Zurück zum Zitat Pirenne MH (1962) Dark adaptation and night vision. In: Davson H (ed) The eye, vol 2. Academic, London, pp 93–122 Pirenne MH (1962) Dark adaptation and night vision. In: Davson H (ed) The eye, vol 2. Academic, London, pp 93–122
5.
Zurück zum Zitat Gunkel RD (1967) Retinal profiles. A psychophysical test of rod and cone sensitivity. Arch Ophthalmol 77:22–25CrossRefPubMed Gunkel RD (1967) Retinal profiles. A psychophysical test of rod and cone sensitivity. Arch Ophthalmol 77:22–25CrossRefPubMed
6.
Zurück zum Zitat Hecht S, Mandelbaum J (1962) From: Pirenne MH, Dark adaptation and night vision. Chapter 5. In: Davson H (ed) The eye, vol 2. Academic, London Hecht S, Mandelbaum J (1962) From: Pirenne MH, Dark adaptation and night vision. Chapter 5. In: Davson H (ed) The eye, vol 2. Academic, London
7.
Zurück zum Zitat Chapanis A (1965) From: Bartlett NR, Dark and light adaptation. In: Graham CH (ed) Vision and visual perception. Wiley, New York Chapanis A (1965) From: Bartlett NR, Dark and light adaptation. In: Graham CH (ed) Vision and visual perception. Wiley, New York
8.
Zurück zum Zitat Aulhorn E, Harms H (1972) In: Jameson D, Hurvich LM (eds) Visual psychophysics, handbook of sensory physiology, vol 7/4. Springer, Berlin, pp 102–145CrossRef Aulhorn E, Harms H (1972) In: Jameson D, Hurvich LM (eds) Visual psychophysics, handbook of sensory physiology, vol 7/4. Springer, Berlin, pp 102–145CrossRef
9.
Zurück zum Zitat Wald G, Zeavin BH (1956) Rod and cone vision in retinitis pigmetosa. Am J Ophthalmol 42:253–269CrossRefPubMed Wald G, Zeavin BH (1956) Rod and cone vision in retinitis pigmetosa. Am J Ophthalmol 42:253–269CrossRefPubMed
10.
Zurück zum Zitat Massof RW, Finkelstein D (1979) Rod sensitivity relative to cone sensitivity in retinitis pigmentosa. Invest Ophthalmol Vis Sci 18(3):263–272PubMed Massof RW, Finkelstein D (1979) Rod sensitivity relative to cone sensitivity in retinitis pigmentosa. Invest Ophthalmol Vis Sci 18(3):263–272PubMed
11.
Zurück zum Zitat Massof RW, Johnson AJ, Finkelstein D (1981) Peripheral absolute threshold spectral sensitivity in retinitis pigmentosa. Br J Ophthalmol 65(2):112–121CrossRefPubMedCentralPubMed Massof RW, Johnson AJ, Finkelstein D (1981) Peripheral absolute threshold spectral sensitivity in retinitis pigmentosa. Br J Ophthalmol 65(2):112–121CrossRefPubMedCentralPubMed
12.
Zurück zum Zitat Jacobson SG, Voigt WJ, Parel JM, Apathy PP, Nghiem-Phu L, Myers SW, Patella VM (1986) Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology 93(12):1604–1611CrossRefPubMed Jacobson SG, Voigt WJ, Parel JM, Apathy PP, Nghiem-Phu L, Myers SW, Patella VM (1986) Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology 93(12):1604–1611CrossRefPubMed
13.
Zurück zum Zitat Krill AE (1972) Hereditary and choroidal diseases. Harper and Row Pub, New York Krill AE (1972) Hereditary and choroidal diseases. Harper and Row Pub, New York
14.
Zurück zum Zitat Lyness AL, Ernst W, Quinlan MP, Clover GM, Arden GB, Carter RM, Bird AC, Parker JA (1985) A clinical, psychophysical, and electroretinographic survey of patients with autosomal dominant retinitis pigmentosa. Br J Ophthalmol 69(5):326–339CrossRefPubMedCentralPubMed Lyness AL, Ernst W, Quinlan MP, Clover GM, Arden GB, Carter RM, Bird AC, Parker JA (1985) A clinical, psychophysical, and electroretinographic survey of patients with autosomal dominant retinitis pigmentosa. Br J Ophthalmol 69(5):326–339CrossRefPubMedCentralPubMed
15.
Zurück zum Zitat Birch DG, Herman WK, deFaller JM, Disbrow DT, Birch EE (1987) The relationship between rod perimetric thresholds and full-field rod ERGs in retinitis pigmentosa. Invest Ophthalmol Vis Sci 28(6):954–965PubMed Birch DG, Herman WK, deFaller JM, Disbrow DT, Birch EE (1987) The relationship between rod perimetric thresholds and full-field rod ERGs in retinitis pigmentosa. Invest Ophthalmol Vis Sci 28(6):954–965PubMed
16.
Zurück zum Zitat Jacobson SG, Kemp CM, Sung CH, Nathans J (1991) Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations. Am J Ophthalmol 112(3):256–271CrossRefPubMed Jacobson SG, Kemp CM, Sung CH, Nathans J (1991) Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations. Am J Ophthalmol 112(3):256–271CrossRefPubMed
17.
Zurück zum Zitat Jacobson SG, Cideciyan AV, Iannaccone A, Weleber RG, Fishman GA, Maguire AM, Affatigato LM, Bennett J, Pierce EA, Danciger M, Farber DB, Stone EM (2000) Disease expression of RP1 mutations causing autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 41(7):1898–1908PubMed Jacobson SG, Cideciyan AV, Iannaccone A, Weleber RG, Fishman GA, Maguire AM, Affatigato LM, Bennett J, Pierce EA, Danciger M, Farber DB, Stone EM (2000) Disease expression of RP1 mutations causing autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 41(7):1898–1908PubMed
18.
Zurück zum Zitat Lorenz B, Andrassi M, Kretschmann U (2003) Phenotype in two families with RP3 associated with RPGR mutations. Ophthalmic Genet 24(2):89–101CrossRefPubMed Lorenz B, Andrassi M, Kretschmann U (2003) Phenotype in two families with RP3 associated with RPGR mutations. Ophthalmic Genet 24(2):89–101CrossRefPubMed
19.
Zurück zum Zitat Rohrschneider K, Bültmann S, Springer C (2008) Use of fundus perimetry (microperimetry) to quantify macular sensitivity. Prog Retin Eye Res 27(5):536–548CrossRefPubMed Rohrschneider K, Bültmann S, Springer C (2008) Use of fundus perimetry (microperimetry) to quantify macular sensitivity. Prog Retin Eye Res 27(5):536–548CrossRefPubMed
20.
Zurück zum Zitat Chen FK, Patel PJ, Xing W, Bunce C, Egan C, Tufail AT, Coffey PJ, Rubin GS, Da Cruz L (2009) Test-retest variability of microperimetry using the Nidek MP1 in patients with macular disease. Invest Ophthalmol Vis Sci 50(7):3464–3472CrossRefPubMed Chen FK, Patel PJ, Xing W, Bunce C, Egan C, Tufail AT, Coffey PJ, Rubin GS, Da Cruz L (2009) Test-retest variability of microperimetry using the Nidek MP1 in patients with macular disease. Invest Ophthalmol Vis Sci 50(7):3464–3472CrossRefPubMed
21.
Zurück zum Zitat Chen FK, Patel PJ, Xing W, Crossland MD, Bunce C, Rubin GS, Da Cruz L (2011) Intrasession repeatability of fixation stability assessment with the Nidek MP-1. Optom Vis Sci 88(6):742–750CrossRefPubMed Chen FK, Patel PJ, Xing W, Crossland MD, Bunce C, Rubin GS, Da Cruz L (2011) Intrasession repeatability of fixation stability assessment with the Nidek MP-1. Optom Vis Sci 88(6):742–750CrossRefPubMed
22.
Zurück zum Zitat Crossland MD, Luong VA, Rubin GS, Fitzke FW (2011) Retinal specific measurement of darkadapted visual function: validation of a modified microperimeter. BMC Ophthalmol 11:5CrossRefPubMedCentralPubMed Crossland MD, Luong VA, Rubin GS, Fitzke FW (2011) Retinal specific measurement of darkadapted visual function: validation of a modified microperimeter. BMC Ophthalmol 11:5CrossRefPubMedCentralPubMed
23.
Zurück zum Zitat Birch DG, Wen Y, Locke K, Hood DC (2011) Rod sensitivity, cone sensitivity, and photoreceptor layer thickness in retinal degenerative diseases. Invest Ophthalmol Vis Sci 52(10):7141–7147CrossRefPubMedCentralPubMed Birch DG, Wen Y, Locke K, Hood DC (2011) Rod sensitivity, cone sensitivity, and photoreceptor layer thickness in retinal degenerative diseases. Invest Ophthalmol Vis Sci 52(10):7141–7147CrossRefPubMedCentralPubMed
24.
Zurück zum Zitat Bowl W, Lorenz B, Jäger M, Friedburg C (2013) Improving detection of mild loss of retinal light increment sensitivity at the posterior pole with the microperimeter MP1. Invest Ophthalmol Vis Sci 54(7):4666–4674CrossRefPubMed Bowl W, Lorenz B, Jäger M, Friedburg C (2013) Improving detection of mild loss of retinal light increment sensitivity at the posterior pole with the microperimeter MP1. Invest Ophthalmol Vis Sci 54(7):4666–4674CrossRefPubMed
25.
Zurück zum Zitat Cornsweet TN (1970) Visual perception. Academic, New York Cornsweet TN (1970) Visual perception. Academic, New York
26.
Zurück zum Zitat Shah VA, Chalam KV (2009) Values for macular perimetry using the MP-1 microperimeter in normal subjects. Ophthalmic Res 41:9–13CrossRefPubMed Shah VA, Chalam KV (2009) Values for macular perimetry using the MP-1 microperimeter in normal subjects. Ophthalmic Res 41:9–13CrossRefPubMed
27.
Zurück zum Zitat Sabates F, Vincent R, Koulen P, Sabates N, Gallimore G (2011) Normative data set identifying properties of the macula across age groups: integration of visual function and retinal structure with microperimetry and spectral-domain optical coherence tomography. Retina 31:1294–1302CrossRefPubMed Sabates F, Vincent R, Koulen P, Sabates N, Gallimore G (2011) Normative data set identifying properties of the macula across age groups: integration of visual function and retinal structure with microperimetry and spectral-domain optical coherence tomography. Retina 31:1294–1302CrossRefPubMed
28.
Zurück zum Zitat Matin L (1975) Ricco’s law: response as a power function of stimulus luminance and distance from target center. Vis Res 15(12):1381–1384CrossRefPubMed Matin L (1975) Ricco’s law: response as a power function of stimulus luminance and distance from target center. Vis Res 15(12):1381–1384CrossRefPubMed
29.
Zurück zum Zitat Piper H (1903) Über das Helligkeitsverhältnis monokular u. binokular ausgelöster Lichtempfindungen. (Fortsetzung der Untersuchungen über Dunkeladaptation des Sehorgans). Z Psychol Physiol Sinnesorgane 32:161–176 Piper H (1903) Über das Helligkeitsverhältnis monokular u. binokular ausgelöster Lichtempfindungen. (Fortsetzung der Untersuchungen über Dunkeladaptation des Sehorgans). Z Psychol Physiol Sinnesorgane 32:161–176
30.
Zurück zum Zitat Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG (2008) Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther 19(10):979–990CrossRefPubMedCentralPubMed Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG (2008) Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther 19(10):979–990CrossRefPubMedCentralPubMed
31.
Zurück zum Zitat Kiser AK, Mladenovich D, Eshraghi F, Bourdeau D, Dagnelie G (2005) Reliability and consistency of dark-adapted psychophysical measures in advanced eye disease. Invest Ophthalmol Vis Sci 47(1):444–452CrossRef Kiser AK, Mladenovich D, Eshraghi F, Bourdeau D, Dagnelie G (2005) Reliability and consistency of dark-adapted psychophysical measures in advanced eye disease. Invest Ophthalmol Vis Sci 47(1):444–452CrossRef
32.
Zurück zum Zitat Stockman A, Sharpe LT (2006) Into the twilight zone: the complexities of mesopic vision and luminous efficiency. Ophthalmic Physiol Opt 26(3):225–239CrossRefPubMed Stockman A, Sharpe LT (2006) Into the twilight zone: the complexities of mesopic vision and luminous efficiency. Ophthalmic Physiol Opt 26(3):225–239CrossRefPubMed
33.
Zurück zum Zitat Hess R, Sharpe L, Nordby K (1990) Night vision. Basic, clinical and applied aspects. Cambridge University Press, Cambridge Hess R, Sharpe L, Nordby K (1990) Night vision. Basic, clinical and applied aspects. Cambridge University Press, Cambridge
34.
Zurück zum Zitat Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292(4):497–523CrossRefPubMed Curcio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292(4):497–523CrossRefPubMed
35.
Zurück zum Zitat Roman AJ, Schwartz SB, Aleman TS, Cideciyan AV, Chico JD, Windsor EA, Gardner LM, Ying GS, Smilko EE, Maquire MG, Jacobson SG (2005) Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measured. Exp Eye Res 80(2):259–272CrossRefPubMed Roman AJ, Schwartz SB, Aleman TS, Cideciyan AV, Chico JD, Windsor EA, Gardner LM, Ying GS, Smilko EE, Maquire MG, Jacobson SG (2005) Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measured. Exp Eye Res 80(2):259–272CrossRefPubMed
Metadaten
Titel
Fundus-controlled two-color dark adaptometry with the Microperimeter MP1
verfasst von
Wadim Bowl
Knut Stieger
Birgit Lorenz
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 6/2015
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-015-3010-6

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