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Current Fungal Infection Reports

Erschienen in:

01.12.2011 | Genomics and Pathogenesis (Shmuel Shoham, Section Editor)

Fungal Infections in Phagocytic Defects

verfasst von: Alexandra F. Freeman, Steven M. Holland

Erschienen in: Current Fungal Infection Reports | Ausgabe 4/2011

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Abstract

Delineating the infection susceptibility of primary immunodeficiencies allows insight into host immunity. Filamentous mold infections are seen most frequently in chronic granulomatous disease, a neutrophil disorder characterized by impaired superoxide production. Mucocutaneous candidiasis occurs in disorders of impaired interleukin (IL)-17 and IL-22 signaling, such as seen in autosomal dominant hyper-IgE (Job’s) syndrome and in disorders with autoantibodies to these cytokines. The endemic dimorphic fungi are in part controlled by disorders of the IL-12/interferon (IFN)-γ pathway, such as IFN-γ receptor and STAT1 defects. Understanding the pathways involved in these primary immunodeficiency disorders will also provide insight into these infections in secondary immunodeficiencies and allow guidance for novel therapies.

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Titel: Fungal Infections in Phagocytic Defects
verfasst von: Alexandra F. Freeman
Steven M. Holland
Publikationsdatum: 01.12.2011
Verlag: Current Science Inc.
Erschienen in: Current Fungal Infection Reports / Ausgabe 4/2011
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI: https://doi.org/10.1007/s12281-011-0063-9

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