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Current Bladder Dysfunction Reports
Erschienen in: Current Bladder Dysfunction Reports 4/2015

01.12.2015 | Reconstructed Bladder Function & Dysfunction (M Kaufman, Section Editor)

Future Perspectives in Bladder Tissue Engineering

verfasst von: Bradley C. Gill, Margot S. Damaser, Christopher J. Chermansky

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2015

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Abstract

Substantial clinical need persists for improved autologous tissues to augment or replace the urinary bladder, and research has begun to address this using tissue engineering techniques. The implantation of both tissue scaffolds, which allow for native bladder tissue ingrowth, and autologous bladder grafts created from in-vitro cellularization of such scaffolds have been tested clinically; however, successful outcomes in both scenarios have been challenged by insufficient vascularity resulting from large graft sizes, which subsequently limits tissue ingrowth and leads to central graft ischemia. Consequently, recent research has focused on developing better methods to produce scaffolds with increased tissue ingrowth and vascularity. This review provides an update on bladder tissue engineering and outlines the challenges that remain to clinical implementation.
Literatur
1.
Carattino MD, Prakasam HS, Ruiz WG, et al. Bladder filling and voiding affect umbrella cell tight junction organization and function. Am J Physiol Ren Physiol. 2013;305:F1158–68.CrossRef
2.
Andersson KE, McCloskey KD. Lamina propria: the functional center of the bladder? Neurourol Urodyn. 2014;33:9–16.CrossRefPubMed
3.
Shah AP, Mevcha A, Wilby D, et al. Continence and micturition: an anatomical basis. Clin Anat. 2014;27:1275–83.CrossRefPubMed
4.•
Lin HK, Madihally SV, Palmer B, et al. Biomatrices for bladder reconstruction. Adv Drug Deliv Rev. 2015;82–83:47–63. An in depth technical review and comparative analysis of bladder engineering techniques. Evaluates various scaffold and graft types, as well as modifications thereof, and their utilization for autologous bladder tissue engineering.CrossRefPubMed
5.
Osborn SL, Kurzrock EA. Bioengineered bladder tissue-close but yet so far! J Urol. 2015;194:619–20.
6.
Atala A. Regenerative bladder augmentation using autologous tissue-when will we get there? J Urol. 2014;191:1204–5.CrossRefPubMed
7.
van Koeveringe GA, Rademakers KL, Birder LA, et al. Detrusor underactivity: pathophysiological considerations, models and proposals for future research. ICI-RS 2013. Neurourol Urodyn. 2014;33:591–6.PubMedCentralCrossRefPubMed
8.
Ng CK, Kauffman EC, Lee MM, et al. A comparison of postoperative complications in open versus robotic cystectomy. Eur Urol. 2010;57:274–81.CrossRefPubMed
9.
Khandelwal P, Abraham SN, Apodaca G. Cell biology and physiology of the uroepithelium. Am J Physiol Ren Physiol. 2009;297:F1477–501.CrossRef
10.
11.
Ochodnicky P, Cruz CD, Yoshimura N, Cruz F. Neurotrophins as regulators of urinary bladder function. Nat Rev Urol. 2012;9:628–37.PubMed
12.
Girard BM, Malley SE, Vizzard MA. Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium. Am J Physiol Ren Physiol. 2011;300:F345–55.CrossRef
13.
14.
Deveaud CM, Macarak EJ, Kucich U, et al. Molecular analysis of collagens in bladder fibrosis. J Urol. 1998;160:1518–27.CrossRefPubMed
15.
Antonakopoulos GN, Hicks RM, Berry RJ. The subcellular basis of damage to the human urinary bladder induced by irradiation. J Pathol. 1984;143:103–16.CrossRefPubMed
16.
Roelofs LA, Kortmann BB, Oosterwijk E, et al. Tissue engineering of diseased bladder using a collagen scaffold in a bladder exstrophy model. BJU Int. 2014;114:447–57.PubMed
17.
Koiso K, Komai T, Niijima T. Experimental urinary bladder reconstruction using a synthetic poly(alpha-amino acids) membrane. Artif Organs. 1983;7:232–7.CrossRefPubMed
18.
Atala A, Freeman MR, Vacanti JP, et al. Implantation in vivo and retrieval of artificial structures consisting of rabbit and human urothelium and human bladder muscle. J Urol. 1993;150:608–12.PubMed
19.•
Song L, Murphy SV, Yang B, et al. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng B Rev. 2014;20:163–72. A review of bladder acellular matrix and its use in augmentation cystoplasty. Reviews the various modifications that have been made to the substrate in differing studies. Highlights that this may be the scaffold of choice moving forward due to its endogenous growth factors and physiologic structure.CrossRef
20.
Griffith CK, Miller C, Sainson RC, et al. Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng. 2005;11:257–66.CrossRefPubMed
21.
Nomi M, Atala A, Coppi PD, Soker S. Principals of neovascularization for tissue engineering. Mol Asp Med. 2002;23:463–83.CrossRef
22.•
Joseph DB, Borer JG, De Filippo RE, et al. Autologous cell seeded biodegradable scaffold for augmentation cystoplasty: phase II study in children and adolescents with spina bifida. J Urol. 2014;191:1389–95. A multicenter clinical study of autologous graft bladder augmentation in children with omental flap overlay. The results of this trial show there is room for improvement in graft viability as well as function.CrossRefPubMed
23.
Pokrywczynska M, Gubanska I, Drewa G, Drewa T. Application of bladder acellular matrix in urinary bladder regeneration: the state of the art and future directions. Biomed Res Int. 2015;2015:613439.PubMedCentralCrossRefPubMed
24.
Zhao Y, He Y, Guo JH, et al. Time-dependent bladder tissue regeneration using bilayer bladder acellular matrix graft-silk fibroin scaffolds in a rat bladder augmentation model. Acta Biomater. 2015;23:91–102.
25.
26.
Thapa A, Webster TJ, Haberstroh KM. Polymers with nano-dimensional surface features enhance bladder smooth muscle cell adhesion. J Biomed Mater Res A. 2003;67:1374–83.CrossRefPubMed
27.
Naji M, Rasouli J, Shakhssalim N, et al. Supportive features of a new hybrid scaffold for urothelium engineering. Arch Med Sci. 2015;11:438–45.PubMedCentralCrossRefPubMed
28.•
Jiang X, Xiong Q, Xu G, et al. VEGF-loaded nanoparticle-modified BAMAs enhance angiogenesis and inhibit graft shrinkage in tissue-engineered bladder. Ann Biomed Eng. 2015;43(10):2577–86. A study showing bladder acellular matrix scaffolds enhanced with vascular endothelial growth factor nanoparticles have better vascularity. Reduced contraction of the implanted acellular scaffolds was also observed.
29.
Youssif M, Shiina H, Urakami S, et al. Effect of vascular endothelial growth factor on regeneration of bladder acellular matrix graft: histologic and functional evaluation. Urology. 2005;66:201–7.CrossRefPubMed
30.
Zhu WD, Xu YM, Feng C, et al. Bladder reconstruction with adipose-derived stem cell-seeded bladder acellular matrix grafts improve morphology composition. World J Urol. 2010;28:493–8.CrossRefPubMed
31.
Zimmern PE, Lin VK, McConnell JD. Smooth-muscle physiology. Urol Clin N Am. 1996;23:211–9.CrossRef
32.
Wei W, Howard PS, Kogan B, Macarak EJ. Urinary diversion results in marked decreases in proliferation and apoptosis in fetal bladder. J Urol. 2012;188:1306–12.CrossRefPubMed
33.
Boruch AV, Nieponice A, Qureshi IR, et al. Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model. J Surg Res. 2010;161:217–25.CrossRefPubMed
34.
Burmeister DM, AbouShwareb T, Bergman CR, et al. Age-related alterations in regeneration of the urinary bladder after subtotal cystectomy. Am J Pathol. 2013;183:1585–95.PubMedCentralCrossRefPubMed
35.
Caione P, Boldrini R, Salerno A, Nappo SG. Bladder augmentation using acellular collagen biomatrix: a pilot experience in exstrophic patients. Pediatr Surg Int. 2012;28:421–8.CrossRefPubMed
36.
37.
Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006;367:1241–6.CrossRefPubMed
38.•
Osborn SL, So M, Hambro S, et al. Inosculation of blood vessels allows early perfusion and vitality of bladder grafts-implications for bioengineered bladder wall. Tissue Eng A. 2015;21:1906–15. A study utilizing autologous bladder patch transplants to study vascularization of tissue grafts. Results showed that host vascularization occurs minimally at graft edges with chimeric vessel formation to take advantage of the established donor tissue circulation.CrossRef
39.
Sharma AK. Is a functional urinary bladder attainable through current regenerative medicine strategies? Cent European J Urol. 2013;66:207–8.PubMedCentralPubMed
40.
Horst M, Madduri S, Gobet R, et al. Engineering functional bladder tissues. J Tissue Eng Regen Med. 2013;7:515–22.CrossRefPubMed
41.
Abdel Hay S, Soliman SM, Debeky ME. Urothelial ingrowth over demucosalized gastrocystoplasty: an experimental study. BJU Int. 2002;90:945–9.CrossRefPubMed
42.
Hidas G, Lee HJ, Bahoric A, et al. Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for bladder augmentation: in vivo, long term, and functional pilot study. J Pediatr Urol. 2015. doi:10.​1016/​j.​jpurol.​2015.​02.​020
43.
Bouhout S, Goulet F, Bolduc S. A novel and faster method to obtain a differentiated 3-dimensional tissue engineered bladder. J Urol. 2015;194:834–41.
Metadaten
Titel
Future Perspectives in Bladder Tissue Engineering
verfasst von
Bradley C. Gill
Margot S. Damaser
Christopher J. Chermansky
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 4/2015
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-015-0327-2

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