Erschienen in:
01.12.1999 | Paper Report
Galectin 1 suppression of collagen-induced arthritis
verfasst von:
David Gould
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Galectin 1 (GAL-1) is a ?-galactosidase-binding protein which participates in carbohydrate recognition processes such as those involved in cell adhesion, cell growth regulation and metastasis. In addition GAL-1 induces apoptosis of activated mature T cells and subsets of immature thymocytes through engagement of CD43 or CD45. These observations suggest that GAL-1 may participate in the induction of immune tolerance. The murine DBA/1 collagen-induced arthritis (CIA) model was used to compare the therapeutic effect of GAL-1 delivery daily as protein or constitutively from genetically modified syngeneic cells. This study was performed to examine the therapeutic potential of GAL-1 in the CIA model, and to examine the contribution of T cell apoptosis to GAL-1 action. …