Erschienen in:
01.04.2011
Ganciclovir-resistant human herpesvirus-6 encephalitis in a liver transplant patient: a case report
verfasst von:
Kelly Baldwin
Erschienen in:
Journal of NeuroVirology
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Ausgabe 2/2011
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Abstract
Human herpesvirus-6 (HHV-6) was initially isolated in 1986 from patients with lymphoproliferative disorders (Ablashi et al.
1987). Since that time, two genetically distinct variants were sequenced, HHV-6A and HHV-6B (Ablashi and Balachandran
1991). Both variants have been linked with neurologic disease (Crawford et al.
2007). HHV-6 encephalitis has been well described in literature, typically presenting with confusion, coma, seizure, and headache. The majority of HHV-6 encephalitis has been limited to post-transplant recipients (Singh and Paterson
2000). Encephalitis due to HHV-6 infection has been reported in two liver transplant recipients (Massih and Razonable
2009 and Montejo et al.
2002). Although there has been in vitro studies regarding the potential resistance patterns for HHV-6 virus, there has been only one clinic case report supporting these findings (Isegawa et al.
2009). We describe the first case of ganciclovir-resistant HHV-6 encephalitis in a post-liver transplant patient.