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2022 | OriginalPaper | Buchkapitel

3. Gastroenterologische Symptome

verfasst von : Boris Zernikow, Jens Berrang, Carola Hasan, Margit Baumann-Köhler, Michael C. Frühwald, Johannes Holzapfel, Silke Kromm, Thomas Berger

Erschienen in: Pädiatrische Palliativversorgung – Schmerzbehandlung und Symptomkontrolle

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Gastroenterologische Symptome sind häufig in der pädiatrischen Palliativversorgung und werden oft als sehr leidvoll erlebt. So tritt z. B. bei etwa 30–40 % der Kinder und Jugendlichen Obstipation auf, zwischen 65 und 70 % aller Kinder und Jugendlichen mit Krebs leiden in den letzten Lebenswochen unter Symptomen von Nausea und Erbrechen. Die Prävalenz einer Malnutrition bei Kindern mit schweren neurologischen Erkrankungen wird auf etwa 30–50 % geschätzt. Begleitsymptome wie Schmerzen, Appetitverlust und Kachexie erhöhen den Leidensdruck des Kindes und beeinträchtigen seine Lebensqualität. Das Kapitel behandelt die relevantesten gastroenterologischen Symptome und stellt praxiserprobte Therapieansätze vor.
Literatur
Zurück zum Zitat Agostini BA, Cericato GO, Silveira ERD et al (2018) How common is dry mouth? Systematic review and meta-regression analysis of prevalence estimates. Braz Dent J 29(6):606–618PubMedCrossRef Agostini BA, Cericato GO, Silveira ERD et al (2018) How common is dry mouth? Systematic review and meta-regression analysis of prevalence estimates. Braz Dent J 29(6):606–618PubMedCrossRef
Zurück zum Zitat Allen G, Logan R, Gue S (2010) Oral manifestations of cancer treatment in children. Clin J Oncol Nurs 14(4):481–490PubMedCrossRef Allen G, Logan R, Gue S (2010) Oral manifestations of cancer treatment in children. Clin J Oncol Nurs 14(4):481–490PubMedCrossRef
Zurück zum Zitat Ang SK, Shoemaker LK, Davis MP (2010) Nausea and vomiting in advanced cancer. Am J Hosp Palliat Med 27(3):219–225CrossRef Ang SK, Shoemaker LK, Davis MP (2010) Nausea and vomiting in advanced cancer. Am J Hosp Palliat Med 27(3):219–225CrossRef
Zurück zum Zitat Arsanious D, Khoury S, Martinez E et al (2016) Ultrasound-guided phrenic nerve block for intractable hiccups following placement of esophageal stent for esophageal squamous cell carcinoma. Pain Physician 19:E653–E6E6PubMedCrossRef Arsanious D, Khoury S, Martinez E et al (2016) Ultrasound-guided phrenic nerve block for intractable hiccups following placement of esophageal stent for esophageal squamous cell carcinoma. Pain Physician 19:E653–E6E6PubMedCrossRef
Zurück zum Zitat Azcona C, Castro L, Crespo E et al (1996) Megestrol acetate therapy for anorexia and weight loss in children with malignant solid tumours. Aliment Pharmacol Ther 10(4):577–586PubMedCrossRef Azcona C, Castro L, Crespo E et al (1996) Megestrol acetate therapy for anorexia and weight loss in children with malignant solid tumours. Aliment Pharmacol Ther 10(4):577–586PubMedCrossRef
Zurück zum Zitat Azkur D, Yoldas T, Toyran M et al (2011) A pediatric case of anaphylaxis due to octreotide. Asian Pac J Allergy Immunol 29(4):361–363PubMed Azkur D, Yoldas T, Toyran M et al (2011) A pediatric case of anaphylaxis due to octreotide. Asian Pac J Allergy Immunol 29(4):361–363PubMed
Zurück zum Zitat Balmer C, Wells AV (1997) Basic principle of cancer treatment and cancer chemotherapy. In: Dipiro J, Talbert R, Yee G (Hrsg) Pharmacotherapy. Appleton and Lange, Stamfort Balmer C, Wells AV (1997) Basic principle of cancer treatment and cancer chemotherapy. In: Dipiro J, Talbert R, Yee G (Hrsg) Pharmacotherapy. Appleton and Lange, Stamfort
Zurück zum Zitat Bateman DN, Rawlins MD, Simpson JM (1985) Extrapyramidal reactions with metoclopramide. Br Med J (Clin Res Ed) 291(6500):930–932CrossRef Bateman DN, Rawlins MD, Simpson JM (1985) Extrapyramidal reactions with metoclopramide. Br Med J (Clin Res Ed) 291(6500):930–932CrossRef
Zurück zum Zitat Bausewein C, Roller R, Voltz R (2018) Leitfaden Palliative Care: Palliativmedizin und Hospizbetreuung. Urban & Fischer, München Bausewein C, Roller R, Voltz R (2018) Leitfaden Palliative Care: Palliativmedizin und Hospizbetreuung. Urban & Fischer, München
Zurück zum Zitat Beckman RA, Siden R, Yanik GA et al (2000) Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. J Pediatr Hematol Oncol 22(4):344–350PubMedCrossRef Beckman RA, Siden R, Yanik GA et al (2000) Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. J Pediatr Hematol Oncol 22(4):344–350PubMedCrossRef
Zurück zum Zitat Bernaola Aponte G, Bada Mancilla CA, Carreazo Pariasca NY et al (2010) Probiotics for treating persistent diarrhoea in children. Cochrane Database Syst Rev 11:CD007401 Bernaola Aponte G, Bada Mancilla CA, Carreazo Pariasca NY et al (2010) Probiotics for treating persistent diarrhoea in children. Cochrane Database Syst Rev 11:CD007401
Zurück zum Zitat Blake P, Delicata R, Cross N et al (2012) Large bowel obstruction due to colorectal carcinoma can be safely treated by colonic stent insertion-case series from a UK district general hospital. Color Dis 14(12):1489–1492CrossRef Blake P, Delicata R, Cross N et al (2012) Large bowel obstruction due to colorectal carcinoma can be safely treated by colonic stent insertion-case series from a UK district general hospital. Color Dis 14(12):1489–1492CrossRef
Zurück zum Zitat Brady MT, Koranyi KI, Hunkler JA (1994) Megestrol acetate for treatment of anorexia associated with human immunodeficiency virus infection in children. Pediatr Infect Dis J 13(8):754–756PubMedCrossRef Brady MT, Koranyi KI, Hunkler JA (1994) Megestrol acetate for treatment of anorexia associated with human immunodeficiency virus infection in children. Pediatr Infect Dis J 13(8):754–756PubMedCrossRef
Zurück zum Zitat Bredenoord AJ (2013) Management of belching, hiccups, and aerophagia. Clin Gastroenterol Hepatol 11(1):6–12PubMedCrossRef Bredenoord AJ (2013) Management of belching, hiccups, and aerophagia. Clin Gastroenterol Hepatol 11(1):6–12PubMedCrossRef
Zurück zum Zitat Brunton LL (1996) Agents affecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes. In: Goodman LS, Limbird LE, Milinoff PB (Hrsg) Goodman and Gilman’s the pharmacological basis of therapeutics. McGraw-Hill, New York, S 917–937 Brunton LL (1996) Agents affecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes. In: Goodman LS, Limbird LE, Milinoff PB (Hrsg) Goodman and Gilman’s the pharmacological basis of therapeutics. McGraw-Hill, New York, S 917–937
Zurück zum Zitat Bujanover Y, Sullivan P, Liebman WM et al (1979) Cholestyramine treatment of chronic diarrhea associated with immune deficiency syndrome. Clin Pediatr (Phila) 18(10):630–633CrossRef Bujanover Y, Sullivan P, Liebman WM et al (1979) Cholestyramine treatment of chronic diarrhea associated with immune deficiency syndrome. Clin Pediatr (Phila) 18(10):630–633CrossRef
Zurück zum Zitat Cherny NI (2008) Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review. J Pain Symptom Manag 36(4):413–423CrossRef Cherny NI (2008) Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review. J Pain Symptom Manag 36(4):413–423CrossRef
Zurück zum Zitat Christensen L, Wildgaard L, Wildgaard K (2016) Permanent catheters for recurrent ascites – a critical and systematic review of study methodology. Support Care Cancer 24(6):2767–2779PubMedCrossRef Christensen L, Wildgaard L, Wildgaard K (2016) Permanent catheters for recurrent ascites – a critical and systematic review of study methodology. Support Care Cancer 24(6):2767–2779PubMedCrossRef
Zurück zum Zitat Clarick RH, Hanekom WA, Yogev R et al (1997) Megestrol acetate treatment of growth failure in children infected with human immunodeficiency virus. Pediatrics 99(3):354–357PubMedCrossRef Clarick RH, Hanekom WA, Yogev R et al (1997) Megestrol acetate treatment of growth failure in children infected with human immunodeficiency virus. Pediatrics 99(3):354–357PubMedCrossRef
Zurück zum Zitat Clarkson JE, Worthington HV, Furness S et al (2010) Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (8):CD001973.pub4 Clarkson JE, Worthington HV, Furness S et al (2010) Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (8):CD001973.pub4
Zurück zum Zitat Clemens KE, Klaschik E (2008) Management of constipation in palliative care patients. Curr Opin Support Palliat Care 2(1):22–27PubMedCrossRef Clemens KE, Klaschik E (2008) Management of constipation in palliative care patients. Curr Opin Support Palliat Care 2(1):22–27PubMedCrossRef
Zurück zum Zitat Coello-Ramirez P (1977) [Cholestyramine in a case of a prolonged diarrhea after a partial ileocolectomy]. Bol Med Hosp Infant Mex 34(2):325–328 Coello-Ramirez P (1977) [Cholestyramine in a case of a prolonged diarrhea after a partial ileocolectomy]. Bol Med Hosp Infant Mex 34(2):325–328
Zurück zum Zitat Cotanch P, Hockenberry M (1985) Self-hypnosis as antiemetic therapy in children receiving chemotherapy. Oncol Nurs Forum 12(4):41–46PubMed Cotanch P, Hockenberry M (1985) Self-hypnosis as antiemetic therapy in children receiving chemotherapy. Oncol Nurs Forum 12(4):41–46PubMed
Zurück zum Zitat Cuvelier GD, Baker TJ, Peddie EF et al (2014) A randomized, double-blind, placebo-controlled clinical trial of megestrol acetate as an appetite stimulant in children with weight loss due to cancer and/or cancer therapy. Pediatr Blood Cancer 61(4):672–679PubMedCrossRef Cuvelier GD, Baker TJ, Peddie EF et al (2014) A randomized, double-blind, placebo-controlled clinical trial of megestrol acetate as an appetite stimulant in children with weight loss due to cancer and/or cancer therapy. Pediatr Blood Cancer 61(4):672–679PubMedCrossRef
Zurück zum Zitat Cymet TC (2002) Retrospective analysis of hiccups in patients at a community hospital from 1995–2000. J Natl Med Assoc 94(6):480–483PubMedPubMedCentral Cymet TC (2002) Retrospective analysis of hiccups in patients at a community hospital from 1995–2000. J Natl Med Assoc 94(6):480–483PubMedPubMedCentral
Zurück zum Zitat Dalgic B, Sari S, Dogan I et al (2005) Chronic intestinal pseudoobstruction: report of four pediatric patients. Turk J Gastroenterol 16(2):93–97PubMed Dalgic B, Sari S, Dogan I et al (2005) Chronic intestinal pseudoobstruction: report of four pediatric patients. Turk J Gastroenterol 16(2):93–97PubMed
Zurück zum Zitat Dand P, Sakel M (2010) The management of drooling in motor neurone disease. Int J Palliat Nurs 16(11):560–564PubMedCrossRef Dand P, Sakel M (2010) The management of drooling in motor neurone disease. Int J Palliat Nurs 16(11):560–564PubMedCrossRef
Zurück zum Zitat De Simone GG, Eisenchlas JH, Junin M et al (2006) Atropine drops for drooling: a randomized controlled trial. Palliat Med 20(7):665–671PubMedCrossRef De Simone GG, Eisenchlas JH, Junin M et al (2006) Atropine drops for drooling: a randomized controlled trial. Palliat Med 20(7):665–671PubMedCrossRef
Zurück zum Zitat Devi KS, Allenidekania A (2019) The relationship of oral care practice at home with mucositis incidence in children with acute lymphoblastic leukemia. Compr Child Adolesc Nurs 42(Suppl 1):56–64PubMedCrossRef Devi KS, Allenidekania A (2019) The relationship of oral care practice at home with mucositis incidence in children with acute lymphoblastic leukemia. Compr Child Adolesc Nurs 42(Suppl 1):56–64PubMedCrossRef
Zurück zum Zitat Dias BLS, Fernandes AR, Maia Filho HS (2017) Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy. Arq Neuropsiquiatr 75(5):282–287PubMedCrossRef Dias BLS, Fernandes AR, Maia Filho HS (2017) Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy. Arq Neuropsiquiatr 75(5):282–287PubMedCrossRef
Zurück zum Zitat Dorman S, Perkins P (2010) Droperidol for treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev 10:CD006938 Dorman S, Perkins P (2010) Droperidol for treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev 10:CD006938
Zurück zum Zitat Drake R, Frost J, Collins JJ (2003) The symptoms of dying children. J Pain Symptom Manag 26(1):594–603CrossRef Drake R, Frost J, Collins JJ (2003) The symptoms of dying children. J Pain Symptom Manag 26(1):594–603CrossRef
Zurück zum Zitat Dupuis LL, Roscoe JA, Olver I et al (2017) 2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy. Support Care Cancer 25(1):317–321PubMedCrossRef Dupuis LL, Roscoe JA, Olver I et al (2017) 2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy. Support Care Cancer 25(1):317–321PubMedCrossRef
Zurück zum Zitat Dy SM, Apostol CC (2010) Evidence-based approaches to other symptoms in advanced cancer. Cancer J 16(5):507PubMedCrossRef Dy SM, Apostol CC (2010) Evidence-based approaches to other symptoms in advanced cancer. Cancer J 16(5):507PubMedCrossRef
Zurück zum Zitat Eberlin M, Chen M, Mueck T et al (2018) Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC Pediatr 18(1):124PubMedPubMedCentralCrossRef Eberlin M, Chen M, Mueck T et al (2018) Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC Pediatr 18(1):124PubMedPubMedCentralCrossRef
Zurück zum Zitat Elfvin A, Göthberg G, Lönroth U et al (2011) Temporary percutaneous and permanent gastric electrical stimulation in children younger than 3 years with chronic vomiting. J Pediatr Surg 46(4):655–661PubMedCrossRef Elfvin A, Göthberg G, Lönroth U et al (2011) Temporary percutaneous and permanent gastric electrical stimulation in children younger than 3 years with chronic vomiting. J Pediatr Surg 46(4):655–661PubMedCrossRef
Zurück zum Zitat Eubanks V, Koppersmith N, Wooldridge N et al (2002) Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis. J Pediatr 140(4):439–444PubMedCrossRef Eubanks V, Koppersmith N, Wooldridge N et al (2002) Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis. J Pediatr 140(4):439–444PubMedCrossRef
Zurück zum Zitat Evans WJ, Morley JE, Argilés J et al (2008) Cachexia: a new definition. Clin Nutr 27(6):793–799PubMedCrossRef Evans WJ, Morley JE, Argilés J et al (2008) Cachexia: a new definition. Clin Nutr 27(6):793–799PubMedCrossRef
Zurück zum Zitat Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12(5):489–495PubMedCrossRef Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12(5):489–495PubMedCrossRef
Zurück zum Zitat Fedorowicz Z, Jagannath VA, Carter B (2011) Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst Rev 7(9):CD005506 Fedorowicz Z, Jagannath VA, Carter B (2011) Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst Rev 7(9):CD005506
Zurück zum Zitat Fesmire FM (1988) Termination of intractable hiccups with digital rectal massage. Ann Emerg Med 17(8):872PubMedCrossRef Fesmire FM (1988) Termination of intractable hiccups with digital rectal massage. Ann Emerg Med 17(8):872PubMedCrossRef
Zurück zum Zitat Flank J, Schechter T, Gibson P et al (2018) Olanzapine for prevention of chemotherapy-induced nausea and vomiting in children and adolescents: a multi-center, feasibility study. Support Care Cancer 26(2):549–555PubMedCrossRef Flank J, Schechter T, Gibson P et al (2018) Olanzapine for prevention of chemotherapy-induced nausea and vomiting in children and adolescents: a multi-center, feasibility study. Support Care Cancer 26(2):549–555PubMedCrossRef
Zurück zum Zitat Fontana M, Zuin G, Massironi E et al (1997) Antibiotic and cholestyramine treatment of chronic diarrhea in HIV-infected children. Ital J Gastroenterol Hepatol 29(1):22–24PubMed Fontana M, Zuin G, Massironi E et al (1997) Antibiotic and cholestyramine treatment of chronic diarrhea in HIV-infected children. Ital J Gastroenterol Hepatol 29(1):22–24PubMed
Zurück zum Zitat Frisancho AR (1981) New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr 34(11):2540–2545PubMedCrossRef Frisancho AR (1981) New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr 34(11):2540–2545PubMedCrossRef
Zurück zum Zitat Gerbes AL, Sauerbruch T, Dathe K (2011) S3-Leitlinie „Aszites, spontan bakterielle Peritonitis, hepatorenales Syndrom“. Z Gastroenterol 49(06):780–787PubMedCrossRef Gerbes AL, Sauerbruch T, Dathe K (2011) S3-Leitlinie „Aszites, spontan bakterielle Peritonitis, hepatorenales Syndrom“. Z Gastroenterol 49(06):780–787PubMedCrossRef
Zurück zum Zitat Gisel EG, Patrick J (1988) Identification of children with cerebral palsy unable to maintain a normal nutritional state. Lancet 331(8580):283–286CrossRef Gisel EG, Patrick J (1988) Identification of children with cerebral palsy unable to maintain a normal nutritional state. Lancet 331(8580):283–286CrossRef
Zurück zum Zitat Gobbo M, Verzegnassi F, Ronfani L et al (2018) Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatr Blood Cancer 65(8):e27098PubMedCrossRef Gobbo M, Verzegnassi F, Ronfani L et al (2018) Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatr Blood Cancer 65(8):e27098PubMedCrossRef
Zurück zum Zitat Gore L, Chawla S, Petrilli A et al (2009) Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability. Pediatr Blood Cancer 52(2):242–247PubMedCrossRef Gore L, Chawla S, Petrilli A et al (2009) Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability. Pediatr Blood Cancer 52(2):242–247PubMedCrossRef
Zurück zum Zitat Gremse DA, Hixon J, Crutchfield A (2002) Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children. Clin Pediatr (Phila) 41(4):225–229CrossRef Gremse DA, Hixon J, Crutchfield A (2002) Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children. Clin Pediatr (Phila) 41(4):225–229CrossRef
Zurück zum Zitat Gryboski JD, Kocoshis S (1990) Effect of bismuth subsalicylate on chronic diarrhea in childhood: a preliminary report. Rev Infect Dis 12(Suppl 1):S36–S40PubMedCrossRef Gryboski JD, Kocoshis S (1990) Effect of bismuth subsalicylate on chronic diarrhea in childhood: a preliminary report. Rev Infect Dis 12(Suppl 1):S36–S40PubMedCrossRef
Zurück zum Zitat Guandalini S (2011) Probiotics for prevention and treatment of diarrhea. J Clin Gastroenterol 45:S149–SS53PubMedCrossRef Guandalini S (2011) Probiotics for prevention and treatment of diarrhea. J Clin Gastroenterol 45:S149–SS53PubMedCrossRef
Zurück zum Zitat Guarino A, Canani RB, Spagnuolo MI et al (1998) In vivo and in vitro efficacy of octreotide for treatment of enteric cryptosporidiosis. Dig Dis Sci 43(2):436–441PubMedCrossRef Guarino A, Canani RB, Spagnuolo MI et al (1998) In vivo and in vitro efficacy of octreotide for treatment of enteric cryptosporidiosis. Dig Dis Sci 43(2):436–441PubMedCrossRef
Zurück zum Zitat Guelaud C, Similowski T, Bizec JL et al (1995) Baclofen therapy for chronic hiccup. Eur Respir J 8(2):235–237PubMedCrossRef Guelaud C, Similowski T, Bizec JL et al (1995) Baclofen therapy for chronic hiccup. Eur Respir J 8(2):235–237PubMedCrossRef
Zurück zum Zitat Gullett NP, Hebbar G, Ziegler TR (2010) Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr 91(4):1143S–1147SPubMedPubMedCentralCrossRef Gullett NP, Hebbar G, Ziegler TR (2010) Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr 91(4):1143S–1147SPubMedPubMedCentralCrossRef
Zurück zum Zitat Guo Q, Goldenberg JZ, Humphrey C et al (2019) Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev (4):CD004827.pub5 Guo Q, Goldenberg JZ, Humphrey C et al (2019) Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev (4):CD004827.pub5
Zurück zum Zitat Hanks GW, Conno F, Cherny N et al (2001) Expert working group of the research network of the European Association for Palliative Care. Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br J Cancer 84:587–593PubMedPubMedCentralCrossRef Hanks GW, Conno F, Cherny N et al (2001) Expert working group of the research network of the European Association for Palliative Care. Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br J Cancer 84:587–593PubMedPubMedCentralCrossRef
Zurück zum Zitat Hardy JR, O’Shea A, White C et al (2010) The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer. J Pain Symptom Manag 40(1):111–116CrossRef Hardy JR, O’Shea A, White C et al (2010) The efficacy of haloperidol in the management of nausea and vomiting in patients with cancer. J Pain Symptom Manag 40(1):111–116CrossRef
Zurück zum Zitat He M, Zhang B, Shen N et al (2018) A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. Eur J Pediatr 177(1):7–17PubMedCrossRef He M, Zhang B, Shen N et al (2018) A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. Eur J Pediatr 177(1):7–17PubMedCrossRef
Zurück zum Zitat Heikenen JB, Pohl JF, Werlin SL et al (2002) Octreotide in pediatric patients. J Pediatr Gastroenterol Nutr 35(5):600PubMedCrossRef Heikenen JB, Pohl JF, Werlin SL et al (2002) Octreotide in pediatric patients. J Pediatr Gastroenterol Nutr 35(5):600PubMedCrossRef
Zurück zum Zitat Hernandez SL, Fasnacht KS, Sheyner I et al (2015) Treatment of refractory hiccups with amantadine. J Pain Palliat Care Pharmacother 29(4):374–377PubMedCrossRef Hernandez SL, Fasnacht KS, Sheyner I et al (2015) Treatment of refractory hiccups with amantadine. J Pain Palliat Care Pharmacother 29(4):374–377PubMedCrossRef
Zurück zum Zitat Hesketh PJ, Grunberg SM, Gralla RJ et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin the Aprepitant Protocol 052 Study Group. J Clin Oncol 21(22):4112–4119PubMedCrossRef Hesketh PJ, Grunberg SM, Gralla RJ et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin the Aprepitant Protocol 052 Study Group. J Clin Oncol 21(22):4112–4119PubMedCrossRef
Zurück zum Zitat Hesketh PJ, Kris MG, Basch E et al (2017) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35(28):3240–3261PubMedCrossRef Hesketh PJ, Kris MG, Basch E et al (2017) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35(28):3240–3261PubMedCrossRef
Zurück zum Zitat Hillesund E, Skranes J, Trygg KU et al (2007) Micronutrient status in children with cerebral palsy. Acta Paediatr 96(8):1195–1198PubMedCrossRef Hillesund E, Skranes J, Trygg KU et al (2007) Micronutrient status in children with cerebral palsy. Acta Paediatr 96(8):1195–1198PubMedCrossRef
Zurück zum Zitat Hiyama T, Yoshihara M, Tanaka S et al (2009) Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol 24(4):537–546PubMedCrossRef Hiyama T, Yoshihara M, Tanaka S et al (2009) Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol 24(4):537–546PubMedCrossRef
Zurück zum Zitat Hobbs DJ, Bunchman TE, Weismantel DP et al (2010) Megestrol acetate improves weight gain in pediatric patients with chronic kidney disease. J Ren Nutr 20(6):408–413PubMedCrossRef Hobbs DJ, Bunchman TE, Weismantel DP et al (2010) Megestrol acetate improves weight gain in pediatric patients with chronic kidney disease. J Ren Nutr 20(6):408–413PubMedCrossRef
Zurück zum Zitat Hockstein NG, Samadi DS, Gendron K et al (2004) Sialorrhea: a management challenge. Am Fam Physician 69(11):2628–2634PubMed Hockstein NG, Samadi DS, Gendron K et al (2004) Sialorrhea: a management challenge. Am Fam Physician 69(11):2628–2634PubMed
Zurück zum Zitat Hooke MC, Grund E, Quammen H et al (2007) Propofol use in pediatric patients with severe cancer pain at the end of life. J Pediatr Oncol Nurs 24(1):29–34PubMedCrossRef Hooke MC, Grund E, Quammen H et al (2007) Propofol use in pediatric patients with severe cancer pain at the end of life. J Pediatr Oncol Nurs 24(1):29–34PubMedCrossRef
Zurück zum Zitat Horimoto Y, Tomie H, Hanzawa K et al (1991) Scopolamine patch reduces postoperative emesis in paediatric patients following strabismus surgery. Can J Anaesth 38(4):441–444PubMedCrossRef Horimoto Y, Tomie H, Hanzawa K et al (1991) Scopolamine patch reduces postoperative emesis in paediatric patients following strabismus surgery. Can J Anaesth 38(4):441–444PubMedCrossRef
Zurück zum Zitat Howard I (2019) Cannabis hyperemesis syndrome in palliative care: a case study and narrative review. J Palliat Med 22:1227–1231PubMedCrossRef Howard I (2019) Cannabis hyperemesis syndrome in palliative care: a case study and narrative review. J Palliat Med 22:1227–1231PubMedCrossRef
Zurück zum Zitat Ianiro G, Rizzatti G, Plomer M et al (2018) Bacillus clausii for the treatment of acute diarrhea in children: a systematic review and meta-analysis of randomized controlled trials. Nutrients 10(8):1074PubMedCentralCrossRef Ianiro G, Rizzatti G, Plomer M et al (2018) Bacillus clausii for the treatment of acute diarrhea in children: a systematic review and meta-analysis of randomized controlled trials. Nutrients 10(8):1074PubMedCentralCrossRef
Zurück zum Zitat Isaac JH (1999) Megestrol acetate treatment of failure to thrive in congenital heart disease. Pediatr Cardiol 20(5):350PubMedCrossRef Isaac JH (1999) Megestrol acetate treatment of failure to thrive in congenital heart disease. Pediatr Cardiol 20(5):350PubMedCrossRef
Zurück zum Zitat Isolauri E, Vesikari T (1985) Oral rehydration, rapid feeding, and cholestyramine for treatment of acute diarrhea. J Pediatr Gastroenterol Nutr 4(3):366–374PubMedCrossRef Isolauri E, Vesikari T (1985) Oral rehydration, rapid feeding, and cholestyramine for treatment of acute diarrhea. J Pediatr Gastroenterol Nutr 4(3):366–374PubMedCrossRef
Zurück zum Zitat Isolauri E, Vesikari T (1986) Effect of cholestyramine on acute diarrhoea in children receiving rapid oral rehydration and full feedings. Ann Clin Res 18(2):99–102PubMed Isolauri E, Vesikari T (1986) Effect of cholestyramine on acute diarrhoea in children receiving rapid oral rehydration and full feedings. Ann Clin Res 18(2):99–102PubMed
Zurück zum Zitat Iwasaki N, Kinugasa H, Watanabe A et al (2007) Hiccup treated by administration of intranasal vinegar. No To Hattatsu 39(3):202–205PubMed Iwasaki N, Kinugasa H, Watanabe A et al (2007) Hiccup treated by administration of intranasal vinegar. No To Hattatsu 39(3):202–205PubMed
Zurück zum Zitat Jacknow DS, Tschann JM, Link MP et al (1994) Hypnosis in the prevention of chemotherapy-related nausea and vomiting in children: a prospective study. J Dev Behav Pediatr 15(4):258–264PubMedCrossRef Jacknow DS, Tschann JM, Link MP et al (1994) Hypnosis in the prevention of chemotherapy-related nausea and vomiting in children: a prospective study. J Dev Behav Pediatr 15(4):258–264PubMedCrossRef
Zurück zum Zitat Jackson WC, Tavernier L (2003) Olanzapine for intractable nausea in palliative care patients. J Palliat Med 6(2):251–255PubMedCrossRef Jackson WC, Tavernier L (2003) Olanzapine for intractable nausea in palliative care patients. J Palliat Med 6(2):251–255PubMedCrossRef
Zurück zum Zitat Jassal SS (2011) Basic symptom control in paediatric palliative care. The Rainbow Children’s Hospice Guidelines. ACT, Bristol Jassal SS (2011) Basic symptom control in paediatric palliative care. The Rainbow Children’s Hospice Guidelines. ACT, Bristol
Zurück zum Zitat Jeon YS, Kearney AM, Baker PG (2018) Management of hiccups in palliative care patients. BMJ Support Palliat Care 8(1):1–6PubMedCrossRef Jeon YS, Kearney AM, Baker PG (2018) Management of hiccups in palliative care patients. BMJ Support Palliat Care 8(1):1–6PubMedCrossRef
Zurück zum Zitat Kang HJ, Loftus S, Taylor A et al (2015) Aprepitant for the prevention of chemotherapy-induced nausea and vomiting in children: a randomised, double-blind, phase 3 trial. Lancet Oncol 16(4):385–394PubMedCrossRef Kang HJ, Loftus S, Taylor A et al (2015) Aprepitant for the prevention of chemotherapy-induced nausea and vomiting in children: a randomised, double-blind, phase 3 trial. Lancet Oncol 16(4):385–394PubMedCrossRef
Zurück zum Zitat Kekomaki M, Vilkki P, Gordin A et al (1981) Loperamide as a symptomatic treatment in pediatric surgery: a double-blind cross-over study. Z Kinderchir 32(3):237–243PubMed Kekomaki M, Vilkki P, Gordin A et al (1981) Loperamide as a symptomatic treatment in pediatric surgery: a double-blind cross-over study. Z Kinderchir 32(3):237–243PubMed
Zurück zum Zitat Keller KM (2002) Evidenzbasierte Therapie der chronischen Obstipation und Enkopresis bei Kindern. Monatsschr Kinderheilk 150(5):594–601CrossRef Keller KM (2002) Evidenzbasierte Therapie der chronischen Obstipation und Enkopresis bei Kindern. Monatsschr Kinderheilk 150(5):594–601CrossRef
Zurück zum Zitat Khoo D, Motson R, Denman K et al (1994) Palliation of malignant intestinal obstruction using octreotide. Eur J Cancer 30(1):28–30CrossRef Khoo D, Motson R, Denman K et al (1994) Palliation of malignant intestinal obstruction using octreotide. Eur J Cancer 30(1):28–30CrossRef
Zurück zum Zitat Knoben JE, Anderson PO (1997) Handbook of clinical drug data. Appleton and Lange, Stamford Knoben JE, Anderson PO (1997) Handbook of clinical drug data. Appleton and Lange, Stamford
Zurück zum Zitat Koga T, Fukuda H (1992) Neurons in the nucleus of the solitary tract mediating inputs from emetic vagal afferents and the area postrema to the pattern generator for the emetic act in dogs. Neurosci Res 14(3):166–179PubMedCrossRef Koga T, Fukuda H (1992) Neurons in the nucleus of the solitary tract mediating inputs from emetic vagal afferents and the area postrema to the pattern generator for the emetic act in dogs. Neurosci Res 14(3):166–179PubMedCrossRef
Zurück zum Zitat Kolodzik PW, Filers MA (1991) Hiccups (singultus): review and approach to management. Ann Emerg Med 20(5):565–573PubMedCrossRef Kolodzik PW, Filers MA (1991) Hiccups (singultus): review and approach to management. Ann Emerg Med 20(5):565–573PubMedCrossRef
Zurück zum Zitat Kovacs G, Wachtel AE, Basharova EV et al (2016) Palonosetron versus ondansetron for prevention of chemotherapy-induced nausea and vomiting in paediatric patients with cancer receiving moderately or highly emetogenic chemotherapy: a randomised, phase 3, double-blind, double-dummy, non-inferiority study. Lancet Oncol 17(3):332–344PubMedCrossRef Kovacs G, Wachtel AE, Basharova EV et al (2016) Palonosetron versus ondansetron for prevention of chemotherapy-induced nausea and vomiting in paediatric patients with cancer receiving moderately or highly emetogenic chemotherapy: a randomised, phase 3, double-blind, double-dummy, non-inferiority study. Lancet Oncol 17(3):332–344PubMedCrossRef
Zurück zum Zitat Kreutzer EW, Milligan FD (1978) Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin. Johns Hopkins Med J 143(3):67–72PubMed Kreutzer EW, Milligan FD (1978) Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin. Johns Hopkins Med J 143(3):67–72PubMed
Zurück zum Zitat Krick J, Murphy PE, Markham JFB et al (1992) A proposed formula for calculating energy needs of children with cerebral palsy. Dev Med Child Neurol 34(6):481–487PubMedCrossRef Krick J, Murphy PE, Markham JFB et al (1992) A proposed formula for calculating energy needs of children with cerebral palsy. Dev Med Child Neurol 34(6):481–487PubMedCrossRef
Zurück zum Zitat Lai JS, Cella D, Peterman A et al (2005) Anorexia/cachexia-related quality of life for children with cancer. Cancer 104(7):1531–1539PubMedCrossRef Lai JS, Cella D, Peterman A et al (2005) Anorexia/cachexia-related quality of life for children with cancer. Cancer 104(7):1531–1539PubMedCrossRef
Zurück zum Zitat Lamireau T, Galperine RI, Ohlbaum P et al (1990) Use of a long acting somatostatin analogue in controlling lleostomy diarrhoea in infants. Acta Paediatr 79(8–9):871–872CrossRef Lamireau T, Galperine RI, Ohlbaum P et al (1990) Use of a long acting somatostatin analogue in controlling lleostomy diarrhoea in infants. Acta Paediatr 79(8–9):871–872CrossRef
Zurück zum Zitat Landers C, Turner D, Makin C et al (2008) Propofol associated hiccups and treatment with lidocaine. Anesth Analg 107(5):1757–1758PubMedCrossRef Landers C, Turner D, Makin C et al (2008) Propofol associated hiccups and treatment with lidocaine. Anesth Analg 107(5):1757–1758PubMedCrossRef
Zurück zum Zitat Lane ER, Hsu EK, Murray KF (2015) Management of ascites in children. Expert Rev Gastroenterol Hepatol 9(10):1281–1292PubMedCrossRef Lane ER, Hsu EK, Murray KF (2015) Management of ascites in children. Expert Rev Gastroenterol Hepatol 9(10):1281–1292PubMedCrossRef
Zurück zum Zitat LeBaron S, Zeltzer L (1984) Behavioral intervention for reducing chemotherapy-related nausea and vomiting in adolescents with cancer. J Adolesc Health Care 5(3):178–182PubMedCrossRef LeBaron S, Zeltzer L (1984) Behavioral intervention for reducing chemotherapy-related nausea and vomiting in adolescents with cancer. J Adolesc Health Care 5(3):178–182PubMedCrossRef
Zurück zum Zitat Lee A, Chan SK, Fan LT (2015) Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev (11):CD003281.pub4 Lee A, Chan SK, Fan LT (2015) Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev (11):CD003281.pub4
Zurück zum Zitat Leelalertlauw C, Mahachoklertwattana P, Hongeng S et al (2018) Megestrol acetate-caused adrenal insufficiency and delayed puberty in a male adolescent with spinal tumour. J Paediatr Child Health 54(2):194–196PubMedCrossRef Leelalertlauw C, Mahachoklertwattana P, Hongeng S et al (2018) Megestrol acetate-caused adrenal insufficiency and delayed puberty in a male adolescent with spinal tumour. J Paediatr Child Health 54(2):194–196PubMedCrossRef
Zurück zum Zitat Lehert P, Chéron G, Calatayud GA et al (2011) Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. Dig Liver Dis 43(9):707–713PubMedCrossRef Lehert P, Chéron G, Calatayud GA et al (2011) Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. Dig Liver Dis 43(9):707–713PubMedCrossRef
Zurück zum Zitat Liacouras CA, Piccoli DA (1996) Whole-bowel irrigation as an adjunct to the treatment of chronic, relapsing clostridium difficile coitis. J Clin Gastroenterol 22(3):186–189PubMedCrossRef Liacouras CA, Piccoli DA (1996) Whole-bowel irrigation as an adjunct to the treatment of chronic, relapsing clostridium difficile coitis. J Clin Gastroenterol 22(3):186–189PubMedCrossRef
Zurück zum Zitat Liang Y, Zhang L, Zeng L et al (2019) Racecadotril for acute diarrhoea in children. Cochrane Database Syst Rev (12):CD009359.pub2 Liang Y, Zhang L, Zeng L et al (2019) Racecadotril for acute diarrhoea in children. Cochrane Database Syst Rev (12):CD009359.pub2
Zurück zum Zitat Litovitz T, Clancy C, Korberly B et al (1997) Surveillance of loperamide ingestions: an analysis of 216 poison center reports. Clin Toxicol 35(1):11–9 Litovitz T, Clancy C, Korberly B et al (1997) Surveillance of loperamide ingestions: an analysis of 216 poison center reports. Clin Toxicol 35(1):11–9
Zurück zum Zitat Liu T-M, Luo Y-W, Tam K-W et al (2019) Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials. Support Care Cancer 27(7):2361–2370PubMedCrossRef Liu T-M, Luo Y-W, Tam K-W et al (2019) Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials. Support Care Cancer 27(7):2361–2370PubMedCrossRef
Zurück zum Zitat Lo Cascio CM, Goetze O, Latshang TD et al (2016) Gastrointestinal dysfunction in patients with Duchenne muscular dystrophy. PLoS One 11(10):e0163779PubMedPubMedCentralCrossRef Lo Cascio CM, Goetze O, Latshang TD et al (2016) Gastrointestinal dysfunction in patients with Duchenne muscular dystrophy. PLoS One 11(10):e0163779PubMedPubMedCentralCrossRef
Zurück zum Zitat Lundström S, Zachrisson U, Fürst CJ (2005) When nothing helps: propofol as sedative and antiemetic in palliative cancer care. J Pain Symptom Manag 30(6):570–577CrossRef Lundström S, Zachrisson U, Fürst CJ (2005) When nothing helps: propofol as sedative and antiemetic in palliative cancer care. J Pain Symptom Manag 30(6):570–577CrossRef
Zurück zum Zitat Luthra P, Burr NE, Brenner DM et al (2019) Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis. Gut 68(3):434–444PubMedCrossRef Luthra P, Burr NE, Brenner DM et al (2019) Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis. Gut 68(3):434–444PubMedCrossRef
Zurück zum Zitat Mak RH (2016) Cachexia in children with chronic kidney disease: challenges in diagnosis and treatment. Curr Opin Support Palliat Care 10(4):293–297PubMedCrossRef Mak RH (2016) Cachexia in children with chronic kidney disease: challenges in diagnosis and treatment. Curr Opin Support Palliat Care 10(4):293–297PubMedCrossRef
Zurück zum Zitat Mangili G, Franchi M, Mariani A et al (1996) Octreotide in the management of bowel obstruction in terminal ovarian cancer. Gynecol Oncol 61(3):345–348PubMedCrossRef Mangili G, Franchi M, Mariani A et al (1996) Octreotide in the management of bowel obstruction in terminal ovarian cancer. Gynecol Oncol 61(3):345–348PubMedCrossRef
Zurück zum Zitat Mannix K (2006) Palliation of nausea and vomiting in malignancy. Clin Med (Northfield Il) 6(2):144–147CrossRef Mannix K (2006) Palliation of nausea and vomiting in malignancy. Clin Med (Northfield Il) 6(2):144–147CrossRef
Zurück zum Zitat Mannix K (2009) Palliation of nausea and vomiting. Br J Hosp Med (Lond) 70(4):192CrossRef Mannix K (2009) Palliation of nausea and vomiting. Br J Hosp Med (Lond) 70(4):192CrossRef
Zurück zum Zitat Marchand V, Motil KJ (2006) Nutrition support for neurologically impaired children: a clinical report of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 43(1):123–135PubMedCrossRef Marchand V, Motil KJ (2006) Nutrition support for neurologically impaired children: a clinical report of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 43(1):123–135PubMedCrossRef
Zurück zum Zitat Marchand V, Baker SS, Stark TJ et al (2000) Randomized, double-blind, placebo-controlled pilot trial of megestrol acetate in malnourished children with cystic fibrosis. J Pediatr Gastroenterol Nutr 31(3):264–269PubMedCrossRef Marchand V, Baker SS, Stark TJ et al (2000) Randomized, double-blind, placebo-controlled pilot trial of megestrol acetate in malnourished children with cystic fibrosis. J Pediatr Gastroenterol Nutr 31(3):264–269PubMedCrossRef
Zurück zum Zitat Marhofer P, Glaser C, Krenn CG et al (1999) Incidence and therapy of midazolam induced hiccups in paediatric anaesthesia. Pediatr Anesth 9(4):295–298CrossRef Marhofer P, Glaser C, Krenn CG et al (1999) Incidence and therapy of midazolam induced hiccups in paediatric anaesthesia. Pediatr Anesth 9(4):295–298CrossRef
Zurück zum Zitat Mazhari F, Shirazi AS, Shabzendehdar M (2019) Management of oral mucositis in pediatric patients receiving cancer therapy: a systematic review and meta-analysis. Pediatr Blood Cancer 66(3):e27403PubMedCrossRef Mazhari F, Shirazi AS, Shabzendehdar M (2019) Management of oral mucositis in pediatric patients receiving cancer therapy: a systematic review and meta-analysis. Pediatr Blood Cancer 66(3):e27403PubMedCrossRef
Zurück zum Zitat Meacham LR, Mazewski C, Krawiecki N (2003) Mechanism of transient adrenal insufficiency with megestrol acetate treatment of cachexia in children with cancer. J Pediatr Hematol Oncol 25(5):414PubMedCrossRef Meacham LR, Mazewski C, Krawiecki N (2003) Mechanism of transient adrenal insufficiency with megestrol acetate treatment of cachexia in children with cancer. J Pediatr Hematol Oncol 25(5):414PubMedCrossRef
Zurück zum Zitat Mercadante S, Spoldi E, Caraceni A et al (1993) Octreotide in relieving gastrointestinal symptoms due to bowel obstruction. Palliat Med 7(4):295–299PubMedCrossRef Mercadante S, Spoldi E, Caraceni A et al (1993) Octreotide in relieving gastrointestinal symptoms due to bowel obstruction. Palliat Med 7(4):295–299PubMedCrossRef
Zurück zum Zitat Mercadante S, Ferrera P, Villari P et al (2004) Aggressive pharmacological treatment for reversing malignant bowel obstruction. J Pain Symptom Manag 28(4):412–416CrossRef Mercadante S, Ferrera P, Villari P et al (2004) Aggressive pharmacological treatment for reversing malignant bowel obstruction. J Pain Symptom Manag 28(4):412–416CrossRef
Zurück zum Zitat Mier RJ, Bachrach SJ, Lakin RC et al (2000) Treatment of sialorrhea with glycopyrrolate: a double-blind, dose-ranging study. Arch Pediatr Adolesc Med 154(12):1214–1218PubMedCrossRef Mier RJ, Bachrach SJ, Lakin RC et al (2000) Treatment of sialorrhea with glycopyrrolate: a double-blind, dose-ranging study. Arch Pediatr Adolesc Med 154(12):1214–1218PubMedCrossRef
Zurück zum Zitat Mikami DLY, Furia CLB, Welker AF (2019) Addition of Kinesio Taping of the orbicularis oris muscles to speech therapy rapidly improves drooling in children with neurological disorders. Dev Neurorehabil 22(1):13–18PubMedCrossRef Mikami DLY, Furia CLB, Welker AF (2019) Addition of Kinesio Taping of the orbicularis oris muscles to speech therapy rapidly improves drooling in children with neurological disorders. Dev Neurorehabil 22(1):13–18PubMedCrossRef
Zurück zum Zitat Montgomery J, McCusker S, Lang K et al (2016) Managing children with sialorrhoea (drooling): experience from the first 301 children in our saliva control clinic. Int J Pediatr Otorhinolaryngol 85:33–39PubMedCrossRef Montgomery J, McCusker S, Lang K et al (2016) Managing children with sialorrhoea (drooling): experience from the first 301 children in our saliva control clinic. Int J Pediatr Otorhinolaryngol 85:33–39PubMedCrossRef
Zurück zum Zitat Moore KP, Wong F, Gines P et al (2003) The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club. Hepatology 38(1):258–266PubMedCrossRef Moore KP, Wong F, Gines P et al (2003) The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club. Hepatology 38(1):258–266PubMedCrossRef
Zurück zum Zitat Motil KJ (1994) Enteral nutrition in the neurologically impaired child. In: Baker SB, Baker RD, Davis A (Hrsg) Pediatric enteral nutrition. Chapman and Hall, New York, S 217–237 Motil KJ (1994) Enteral nutrition in the neurologically impaired child. In: Baker SB, Baker RD, Davis A (Hrsg) Pediatric enteral nutrition. Chapman and Hall, New York, S 217–237
Zurück zum Zitat Nadaraja S, Mamoudou AD, Thomassen H et al (2012) Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate. Pediatr Blood Cancer 59(5):870–873PubMedCrossRef Nadaraja S, Mamoudou AD, Thomassen H et al (2012) Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate. Pediatr Blood Cancer 59(5):870–873PubMedCrossRef
Zurück zum Zitat Nanba Y, Oka A, Ohno K (2007) Severe diarrhea associated with X-linked lissencephaly with absent corpus callosum and abnormal genitalia: a case report of successful treatment with the somatostatin analogue octreotide. No To Hattatsu 39(5):379–382PubMed Nanba Y, Oka A, Ohno K (2007) Severe diarrhea associated with X-linked lissencephaly with absent corpus callosum and abnormal genitalia: a case report of successful treatment with the somatostatin analogue octreotide. No To Hattatsu 39(5):379–382PubMed
Zurück zum Zitat Narayanan G, Pezeshkmehr A, Venkat S et al (2014) Safety and efficacy of the PleurX catheter for the treatment of malignant ascites. J Palliat Med 17(8):906–912PubMedPubMedCentralCrossRef Narayanan G, Pezeshkmehr A, Venkat S et al (2014) Safety and efficacy of the PleurX catheter for the treatment of malignant ascites. J Palliat Med 17(8):906–912PubMedPubMedCentralCrossRef
Zurück zum Zitat Nasr SZ, Hurwitz ME, Brown RW et al (1999) Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis. Pediatr Pulmonol 28:380–382PubMedCrossRef Nasr SZ, Hurwitz ME, Brown RW et al (1999) Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis. Pediatr Pulmonol 28:380–382PubMedCrossRef
Zurück zum Zitat Nolte-Buchholtz S, Zernikow B, Wager J (2018) Pediatric patients receiving specialized palliative home care according to German law: a prospective multicenter cohort study. Children (Basel, Switzerland) 5(6):E66 Nolte-Buchholtz S, Zernikow B, Wager J (2018) Pediatric patients receiving specialized palliative home care according to German law: a prospective multicenter cohort study. Children (Basel, Switzerland) 5(6):E66
Zurück zum Zitat Ofir R, Bar-Sela G, Weyl Ben-Arush M et al (2019) Medical marijuana use for pediatric oncology patients: single institution experience. Pediatr Hematol Oncol 36(5):255–266PubMedCrossRef Ofir R, Bar-Sela G, Weyl Ben-Arush M et al (2019) Medical marijuana use for pediatric oncology patients: single institution experience. Pediatr Hematol Oncol 36(5):255–266PubMedCrossRef
Zurück zum Zitat Ohlrich M, Royl G (2017) Singultus–Diagnostik und Therapie. Laryngo-Rhino-Otologie 96(07):446–455CrossRef Ohlrich M, Royl G (2017) Singultus–Diagnostik und Therapie. Laryngo-Rhino-Otologie 96(07):446–455CrossRef
Zurück zum Zitat Okumura LM, Rodrigues FDA, Ferreira MAP et al (2017) Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta-analyses of randomized controlled trials. Br J Clin Pharmacol 83(5):1108–1117PubMedPubMedCentralCrossRef Okumura LM, Rodrigues FDA, Ferreira MAP et al (2017) Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta-analyses of randomized controlled trials. Br J Clin Pharmacol 83(5):1108–1117PubMedPubMedCentralCrossRef
Zurück zum Zitat Orme LM, Bond JD, Humphrey MS et al (2003) Megestrol Acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. Cancer 98(2):397–405PubMedCrossRef Orme LM, Bond JD, Humphrey MS et al (2003) Megestrol Acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. Cancer 98(2):397–405PubMedCrossRef
Zurück zum Zitat Pai V, Porter K, Ranalli M (2011) Octreotide acetate is efficacious and safe in children for treating diarrhea due to chemotherapy but not acute graft versus host disease. Pediatr Blood Cancer 56(1):45–49PubMedCrossRef Pai V, Porter K, Ranalli M (2011) Octreotide acetate is efficacious and safe in children for treating diarrhea due to chemotherapy but not acute graft versus host disease. Pediatr Blood Cancer 56(1):45–49PubMedCrossRef
Zurück zum Zitat Parr JR, Todhunter E, Pennington L et al (2018) Drooling Reduction Intervention randomised trial (DRI): comparing the efficacy and acceptability of hyoscine patches and glycopyrronium liquid on drooling in children with neurodisability. Arch Dis Child 103(4):371–376PubMedCrossRef Parr JR, Todhunter E, Pennington L et al (2018) Drooling Reduction Intervention randomised trial (DRI): comparing the efficacy and acceptability of hyoscine patches and glycopyrronium liquid on drooling in children with neurodisability. Arch Dis Child 103(4):371–376PubMedCrossRef
Zurück zum Zitat Pascual Lopez A, Figuls M, Urrutia Cuchi G et al (2004) Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manag 27(4):360–369CrossRef Pascual Lopez A, Figuls M, Urrutia Cuchi G et al (2004) Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manag 27(4):360–369CrossRef
Zurück zum Zitat Passik SD, Lundberg J, Kirsh KL et al (2002) A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. J Pain Symptom Manag 23(6):526–532CrossRef Passik SD, Lundberg J, Kirsh KL et al (2002) A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. J Pain Symptom Manag 23(6):526–532CrossRef
Zurück zum Zitat Patel P, Robinson PD, Thackray J et al (2017) Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatr Blood Cancer 64(10):e26542CrossRef Patel P, Robinson PD, Thackray J et al (2017) Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatr Blood Cancer 64(10):e26542CrossRef
Zurück zum Zitat Patro-Gołąb B, Szajewska H (2019) Systematic review with meta-analysis: lactobacillus reuteri DSM 17938 for treating acute gastroenteritis in children. An update. Nutrients 11(11):2762PubMedCentralCrossRef Patro-Gołąb B, Szajewska H (2019) Systematic review with meta-analysis: lactobacillus reuteri DSM 17938 for treating acute gastroenteritis in children. An update. Nutrients 11(11):2762PubMedCentralCrossRef
Zurück zum Zitat Petroianu G, Hein G, Petroianu A et al (1997) Idiopathic chronic hiccup: combination therapy with cisapride, omeprazole, and baclofen. Clin Ther 19(5):1031–1038PubMedCrossRef Petroianu G, Hein G, Petroianu A et al (1997) Idiopathic chronic hiccup: combination therapy with cisapride, omeprazole, and baclofen. Clin Ther 19(5):1031–1038PubMedCrossRef
Zurück zum Zitat Phillips RS, Gibson F (2008) A systematic review of treatments for constipation in children and young adults undergoing cancer treatment. J Pediatr Hematol Oncol 30(11):829–830PubMedCrossRef Phillips RS, Gibson F (2008) A systematic review of treatments for constipation in children and young adults undergoing cancer treatment. J Pediatr Hematol Oncol 30(11):829–830PubMedCrossRef
Zurück zum Zitat Phillips RS, Friend AJ, Gibson F et al (2016) Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood. Cochrane Database Syst Rev (2):CD007786.pub3 Phillips RS, Friend AJ, Gibson F et al (2016) Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood. Cochrane Database Syst Rev (2):CD007786.pub3
Zurück zum Zitat Porreca F, Ossipov MH (2009) Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Med 10(4):654–662PubMedCrossRef Porreca F, Ossipov MH (2009) Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Med 10(4):654–662PubMedCrossRef
Zurück zum Zitat Porzio G, Aielli F, Verna L et al (2010) Gabapentin in the treatment of hiccups in patients with advanced cancer: a 5-year experience. Clin Neuropharmacol 33(4):179PubMedCrossRef Porzio G, Aielli F, Verna L et al (2010) Gabapentin in the treatment of hiccups in patients with advanced cancer: a 5-year experience. Clin Neuropharmacol 33(4):179PubMedCrossRef
Zurück zum Zitat Potter J, Hami F, Bryan T et al (2003) Symptoms in 400 patients referred to palliative care services: prevalence and patterns. Palliat Med 17(4):310–314PubMedCrossRef Potter J, Hami F, Bryan T et al (2003) Symptoms in 400 patients referred to palliative care services: prevalence and patterns. Palliat Med 17(4):310–314PubMedCrossRef
Zurück zum Zitat Rapoport A (2010) Sublingual atropine drops for the treatment of pediatric sialorrhea. J Pain Symptom Manag 40(5):783–788CrossRef Rapoport A (2010) Sublingual atropine drops for the treatment of pediatric sialorrhea. J Pain Symptom Manag 40(5):783–788CrossRef
Zurück zum Zitat Rees H, Markley MA, Kiely EM et al (1998) Diarrhea after resection of advanced abdominal neuroblastoma: a common management problem. Surgery 123(5):568–572PubMedCrossRef Rees H, Markley MA, Kiely EM et al (1998) Diarrhea after resection of advanced abdominal neuroblastoma: a common management problem. Surgery 123(5):568–572PubMedCrossRef
Zurück zum Zitat Reid SM, Johnson HM, Reddihough DS (2010) The Drooling Impact Scale: a measure of the impact of drooling in children with developmental disabilities. Dev Med Child Neurol 52(2):e23–ee8PubMedCrossRef Reid SM, Johnson HM, Reddihough DS (2010) The Drooling Impact Scale: a measure of the impact of drooling in children with developmental disabilities. Dev Med Child Neurol 52(2):e23–ee8PubMedCrossRef
Zurück zum Zitat Riad W, Altaf R, Abdulla A et al (2007) Effect of midazolam, dexamethasone and their combination on the prevention of nausea and vomiting following strabismus repair in children. Eur J Anaesthesiol 24(8):697–701PubMedCrossRef Riad W, Altaf R, Abdulla A et al (2007) Effect of midazolam, dexamethasone and their combination on the prevention of nausea and vomiting following strabismus repair in children. Eur J Anaesthesiol 24(8):697–701PubMedCrossRef
Zurück zum Zitat Richardson J, Smith JE, McCall G et al (2007) Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. Eur J Cancer Care 16(5):402–412CrossRef Richardson J, Smith JE, McCall G et al (2007) Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. Eur J Cancer Care 16(5):402–412CrossRef
Zurück zum Zitat Riley P, Glenny AM, Worthington HV et al (2017) Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. Cochrane Database Syst Rev (11):CD011990 Riley P, Glenny AM, Worthington HV et al (2017) Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. Cochrane Database Syst Rev (11):CD011990
Zurück zum Zitat Ripaldi M, Parasole R, De Simone G et al (2010) Palonosetron to prevent nausea and vomiting in children undergoing BMT. Efficacy and safety. Bone Marrow Transplant 45:1663–1664PubMedCrossRef Ripaldi M, Parasole R, De Simone G et al (2010) Palonosetron to prevent nausea and vomiting in children undergoing BMT. Efficacy and safety. Bone Marrow Transplant 45:1663–1664PubMedCrossRef
Zurück zum Zitat Roila F, Herrstedt J, Aapro M et al (2010) Guideline update for MASCC and ESMO in the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol 21(Suppl 5):v232–vv43PubMedCrossRef Roila F, Herrstedt J, Aapro M et al (2010) Guideline update for MASCC and ESMO in the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol 21(Suppl 5):v232–vv43PubMedCrossRef
Zurück zum Zitat Romano C, Van Wynckel M, Hulst J et al (2017) European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with neurological impairment. J Pediatr Gastroenterol Nutr 65(2):242–264PubMedCrossRef Romano C, Van Wynckel M, Hulst J et al (2017) European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with neurological impairment. J Pediatr Gastroenterol Nutr 65(2):242–264PubMedCrossRef
Zurück zum Zitat Roscoe JA, Morrow GR, Aapro MS et al (2011) Anticipatory nausea and vomiting. Support Care Cancer 19(10):1533–1538PubMedCrossRef Roscoe JA, Morrow GR, Aapro MS et al (2011) Anticipatory nausea and vomiting. Support Care Cancer 19(10):1533–1538PubMedCrossRef
Zurück zum Zitat Sabri M, Saps M, Peters JM (2003) Pathophysiology and management of pediatric ascites. Curr Gastroenterol Rep 5(3):240–246PubMedCrossRef Sabri M, Saps M, Peters JM (2003) Pathophysiology and management of pediatric ascites. Curr Gastroenterol Rep 5(3):240–246PubMedCrossRef
Zurück zum Zitat Sadeghi M, Keshavarz-Fathi M, Baracos V et al (2018) Cancer cachexia: diagnosis, assessment, and treatment. Crit Rev Oncol Hematol 127:91–104PubMedCrossRef Sadeghi M, Keshavarz-Fathi M, Baracos V et al (2018) Cancer cachexia: diagnosis, assessment, and treatment. Crit Rev Oncol Hematol 127:91–104PubMedCrossRef
Zurück zum Zitat Schmid I, Stachel DK, Freudenberg S et al (2002) Megestrol acetate to correct the nutritional status in an adolescent with growth hormone deficiency: increase of appetite and body weight but only by increase of body water and fat mass followed by profound cortisol and testosterone depletion. Klin Paediatr 214(2):54–57CrossRef Schmid I, Stachel DK, Freudenberg S et al (2002) Megestrol acetate to correct the nutritional status in an adolescent with growth hormone deficiency: increase of appetite and body weight but only by increase of body water and fat mass followed by profound cortisol and testosterone depletion. Klin Paediatr 214(2):54–57CrossRef
Zurück zum Zitat Schroeder AS, Kling T, Huß K et al (2012) Botulinum toxin type A and B for the reduction of hypersalivation in children with neurological disorders: a focus on effectiveness and therapy adherence. Neuropediatrics 43(01):027–036CrossRef Schroeder AS, Kling T, Huß K et al (2012) Botulinum toxin type A and B for the reduction of hypersalivation in children with neurological disorders: a focus on effectiveness and therapy adherence. Neuropediatrics 43(01):027–036CrossRef
Zurück zum Zitat Schroeter E, Schmitz A, Haas T et al (2012) „Low-dose“-Droperidol-Gabe bei Kindern. Anaesthesist 61(1):30–34PubMedCrossRef Schroeter E, Schmitz A, Haas T et al (2012) „Low-dose“-Droperidol-Gabe bei Kindern. Anaesthesist 61(1):30–34PubMedCrossRef
Zurück zum Zitat Seker MM, Aksoy S, Özdemir NY et al (2012) Successful treatment of chronic hiccup with baclofen in cancer patients. Med Oncol 29(2):1369–1370PubMedCrossRef Seker MM, Aksoy S, Özdemir NY et al (2012) Successful treatment of chronic hiccup with baclofen in cancer patients. Med Oncol 29(2):1369–1370PubMedCrossRef
Zurück zum Zitat Smith AR, Repka TL, Weigel BJ (2005) Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents. Pediatr Blood Cancer 45(6):857–860PubMedCrossRef Smith AR, Repka TL, Weigel BJ (2005) Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents. Pediatr Blood Cancer 45(6):857–860PubMedCrossRef
Zurück zum Zitat Smith HS, Busracamwongs A (2003) Management of hiccups in the palliative care population. Am J Hosp Palliat Med 20(2):149–154CrossRef Smith HS, Busracamwongs A (2003) Management of hiccups in the palliative care population. Am J Hosp Palliat Med 20(2):149–154CrossRef
Zurück zum Zitat Smith RG, Burtner AP (1994) Oral side-effects of the most frequently prescribed drugs. Spec Care Dentist 14(3):96–102PubMedCrossRef Smith RG, Burtner AP (1994) Oral side-effects of the most frequently prescribed drugs. Spec Care Dentist 14(3):96–102PubMedCrossRef
Zurück zum Zitat Smith SS, Shulman DI, O’Dorisio TM et al (1987) Watery diarrhea, hypokalemia, achlorhydria syndrome in an infant: effect of the long-acting somatostatin analogue SMS 201-995 on the disease and linear growth. J Pediatr Gastroenterol Nutr 6(5):710–716PubMedCrossRef Smith SS, Shulman DI, O’Dorisio TM et al (1987) Watery diarrhea, hypokalemia, achlorhydria syndrome in an infant: effect of the long-acting somatostatin analogue SMS 201-995 on the disease and linear growth. J Pediatr Gastroenterol Nutr 6(5):710–716PubMedCrossRef
Zurück zum Zitat Soriano A, Davis MP (2011) Malignant bowel obstruction: individualized treatment near the end of life. Cleve Clin J Med 78(3):197–206PubMedCrossRef Soriano A, Davis MP (2011) Malignant bowel obstruction: individualized treatment near the end of life. Cleve Clin J Med 78(3):197–206PubMedCrossRef
Zurück zum Zitat Souadjian JV, Cain JC (1968) Intractable hiccup. Etiologic factors in 220 cases. Postgrad Med 43(2):72PubMedCrossRef Souadjian JV, Cain JC (1968) Intractable hiccup. Etiologic factors in 220 cases. Postgrad Med 43(2):72PubMedCrossRef
Zurück zum Zitat Spender QW, Cronk CE, Charney EB et al (1989) Assessment of linear growth of children with cerebral palsy: use of alternative measures to height or length. Dev Med Child Neurol 31(2):206–214PubMedCrossRef Spender QW, Cronk CE, Charney EB et al (1989) Assessment of linear growth of children with cerebral palsy: use of alternative measures to height or length. Dev Med Child Neurol 31(2):206–214PubMedCrossRef
Zurück zum Zitat Steffen A, Jost W, Bäumer T et al (2019) Hypersalivation: update of the German S2k guideline (AWMF) in short form. J Neural Transm 126(7):853–862PubMedCrossRef Steffen A, Jost W, Bäumer T et al (2019) Hypersalivation: update of the German S2k guideline (AWMF) in short form. J Neural Transm 126(7):853–862PubMedCrossRef
Zurück zum Zitat Steger M, Schneemann M, Fox M (2015) Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther 42(9):1037–1050PubMedCrossRef Steger M, Schneemann M, Fox M (2015) Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther 42(9):1037–1050PubMedCrossRef
Zurück zum Zitat Stockheim JA, Daaboul JJ, Yogev R et al (1999) Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate. J Pediatr 134(3):368–370PubMedCrossRef Stockheim JA, Daaboul JJ, Yogev R et al (1999) Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate. J Pediatr 134(3):368–370PubMedCrossRef
Zurück zum Zitat Stockhorst U, Wiener JA, Klosterhalfen S et al (1998) Effects of overshadowing on conditioned nausea in cancer patients: an experimental study. Physiol Behav 64(5):743–753PubMedCrossRef Stockhorst U, Wiener JA, Klosterhalfen S et al (1998) Effects of overshadowing on conditioned nausea in cancer patients: an experimental study. Physiol Behav 64(5):743–753PubMedCrossRef
Zurück zum Zitat Stueber D, Swartz CM (2006) Carvedilol suppresses intractable hiccups. J Am Board Fam Med 19(4):418–421PubMedCrossRef Stueber D, Swartz CM (2006) Carvedilol suppresses intractable hiccups. J Am Board Fam Med 19(4):418–421PubMedCrossRef
Zurück zum Zitat Sullivan PB, Lambert B, Rose M et al (2000) Prevalence and severity of feeding and nutritional problems in children with neurological impairment: Oxford Feeding Study. Dev Med Child Neurol 42(10):674–680PubMedCrossRef Sullivan PB, Lambert B, Rose M et al (2000) Prevalence and severity of feeding and nutritional problems in children with neurological impairment: Oxford Feeding Study. Dev Med Child Neurol 42(10):674–680PubMedCrossRef
Zurück zum Zitat Sung L, Robinson P, Treister N et al (2017) Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care 7(1):7–16PubMedCrossRef Sung L, Robinson P, Treister N et al (2017) Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care 7(1):7–16PubMedCrossRef
Zurück zum Zitat Sweeney MP, Bagg J (1995) Oral care for hospice patients with advanced cancer. Dent Update 22(10):424–427PubMed Sweeney MP, Bagg J (1995) Oral care for hospice patients with advanced cancer. Dent Update 22(10):424–427PubMed
Zurück zum Zitat Szajewska H, Kołodziej M, Gieruszczak-Białek D et al (2019) Systematic review with meta-analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children–a 2019 update. Aliment Pharmacol Ther 49(11):1376–1384PubMedCrossRef Szajewska H, Kołodziej M, Gieruszczak-Białek D et al (2019) Systematic review with meta-analysis: Lactobacillus rhamnosus GG for treating acute gastroenteritis in children–a 2019 update. Aliment Pharmacol Ther 49(11):1376–1384PubMedCrossRef
Zurück zum Zitat Tambucci R, Quitadamo P, Thapar N et al (2018) Diagnostic tests in pediatric constipation. J Pediatr Gastroenterol Nutr 66(4):e89–e98PubMedCrossRef Tambucci R, Quitadamo P, Thapar N et al (2018) Diagnostic tests in pediatric constipation. J Pediatr Gastroenterol Nutr 66(4):e89–e98PubMedCrossRef
Zurück zum Zitat Tan J, Wang S, Liang X et al (2018) Palonosetron is nonsuperior to ondansetron in acute phase but provides superior antiemetic control in delayed phase for pediatric patients administered highly emetogenic chemotherapy. Pediatr Blood Cancer 65(2):e26815CrossRef Tan J, Wang S, Liang X et al (2018) Palonosetron is nonsuperior to ondansetron in acute phase but provides superior antiemetic control in delayed phase for pediatric patients administered highly emetogenic chemotherapy. Pediatr Blood Cancer 65(2):e26815CrossRef
Zurück zum Zitat Tanasiewicz M, Hildebrandt T, Obersztyn I (2016) Xerostomia of various etiologies: a review of the literature. Adv Clin Exp Med 25(1):199–206PubMedCrossRef Tanasiewicz M, Hildebrandt T, Obersztyn I (2016) Xerostomia of various etiologies: a review of the literature. Adv Clin Exp Med 25(1):199–206PubMedCrossRef
Zurück zum Zitat Tay SS, Yadav RR (2010) Novel use of baclofen in cancer patients for the treatment of hiccups. Ann Acad Med Singap 39(2):154PubMed Tay SS, Yadav RR (2010) Novel use of baclofen in cancer patients for the treatment of hiccups. Ann Acad Med Singap 39(2):154PubMed
Zurück zum Zitat Tegeler ML, Baumrucker SJ (2008) Gabapentin for intractable hiccups in palliative care. Am J Hosp Palliat Med 25(1):52–54CrossRef Tegeler ML, Baumrucker SJ (2008) Gabapentin for intractable hiccups in palliative care. Am J Hosp Palliat Med 25(1):52–54CrossRef
Zurück zum Zitat Tolia V, Lin CH, Sur Y (1993) A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal impaction in children. Aliment Pharmacol Ther 7(5):523–529PubMedCrossRef Tolia V, Lin CH, Sur Y (1993) A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal impaction in children. Aliment Pharmacol Ther 7(5):523–529PubMedCrossRef
Zurück zum Zitat Tramèr MR, Carroll D, Campbell FA et al (2001) Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. Br Med J 323(7303):16–21CrossRef Tramèr MR, Carroll D, Campbell FA et al (2001) Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. Br Med J 323(7303):16–21CrossRef
Zurück zum Zitat Twycross R, Back I (1998) Nausea and vomiting in advanced cancer. Eur J Palliat Care 5:39–45 Twycross R, Back I (1998) Nausea and vomiting in advanced cancer. Eur J Palliat Care 5:39–45
Zurück zum Zitat Uhlig U, Pfeil N, Gelbrich G et al (2009) Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT. Pediatrics 124(4):e622–ee32PubMedCrossRef Uhlig U, Pfeil N, Gelbrich G et al (2009) Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT. Pediatrics 124(4):e622–ee32PubMedCrossRef
Zurück zum Zitat Ventafridda V, Oliveri E, Caraceni A et al (1987) A retrospective study on the use of oral morphine in cancer pain. J Pain Symptom Manag 2(2):77–81CrossRef Ventafridda V, Oliveri E, Caraceni A et al (1987) A retrospective study on the use of oral morphine in cancer pain. J Pain Symptom Manag 2(2):77–81CrossRef
Zurück zum Zitat Vesikari T, Isolauri E (1985) A comparative trial of cholestyramine and loperamide for acute diarrhoea in infants treated as outpatients. Acta Paediatr 74(5):650–654CrossRef Vesikari T, Isolauri E (1985) A comparative trial of cholestyramine and loperamide for acute diarrhoea in infants treated as outpatients. Acta Paediatr 74(5):650–654CrossRef
Zurück zum Zitat Vigarios E, Epstein JB, Sibaud V (2017) Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors. Support Care Cancer 25(5):1713–1739PubMedCrossRef Vigarios E, Epstein JB, Sibaud V (2017) Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors. Support Care Cancer 25(5):1713–1739PubMedCrossRef
Zurück zum Zitat Walsh D, Donnelly S, Rybicki L (2000) The symptoms of advanced cancer: relationshipn to age, gender, and performance status in 1,000 patients. Support Care Cancer 8(3):175–179PubMedCrossRef Walsh D, Donnelly S, Rybicki L (2000) The symptoms of advanced cancer: relationshipn to age, gender, and performance status in 1,000 patients. Support Care Cancer 8(3):175–179PubMedCrossRef
Zurück zum Zitat Watanabe H, Inoue Y, Uchida K et al (2007) Octreotide improved the quality of life in a child with malignant bowel obstruction caused by peritoneal dissemination of colon cancer. J Pediatr Surg 42(1):259–260PubMedCrossRef Watanabe H, Inoue Y, Uchida K et al (2007) Octreotide improved the quality of life in a child with malignant bowel obstruction caused by peritoneal dissemination of colon cancer. J Pediatr Surg 42(1):259–260PubMedCrossRef
Zurück zum Zitat Waterham M, Kaufman J, Gibb S (2017) Childhood constipation. Aust Fam Physician 46(12):908–912PubMed Waterham M, Kaufman J, Gibb S (2017) Childhood constipation. Aust Fam Physician 46(12):908–912PubMed
Zurück zum Zitat Waterlow JC, Buzina R, Keller W et al (1977) The presentation and use of height and weight data for comparing the nutritional status of groups of children under the age of 10 years. Bull World Health Organ 55(4):489–498PubMedPubMedCentral Waterlow JC, Buzina R, Keller W et al (1977) The presentation and use of height and weight data for comparing the nutritional status of groups of children under the age of 10 years. Bull World Health Organ 55(4):489–498PubMedPubMedCentral
Zurück zum Zitat Wolfe J, Grier HE, Klar N et al (2000) Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342(5):326–333PubMedCrossRef Wolfe J, Grier HE, Klar N et al (2000) Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342(5):326–333PubMedCrossRef
Zurück zum Zitat Wong SS, Wilens TE (2017) Medical cannabinoids in children and adolescents: a systematic review. Pediatrics 140(5):e20171818PubMedCrossRef Wong SS, Wilens TE (2017) Medical cannabinoids in children and adolescents: a systematic review. Pediatrics 140(5):e20171818PubMedCrossRef
Zurück zum Zitat Worthington HV, Clarkson JE, Eden OB (2011) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (4):CD000978 Worthington HV, Clarkson JE, Eden OB (2011) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev (4):CD000978
Zurück zum Zitat Wright J, Gundry SW, Conroy RM (2007) A review of changing episode definitions and their effects on estimates of diarrhoeal morbidity. J Health Popul Nutr 25(4):448–455PubMedPubMedCentral Wright J, Gundry SW, Conroy RM (2007) A review of changing episode definitions and their effects on estimates of diarrhoeal morbidity. J Health Popul Nutr 25(4):448–455PubMedPubMedCentral
Zurück zum Zitat Yachha SK, Khanna V (2006) Ascites in childhood liver disease. Indian J Pediatr 73(9):819–824PubMedCrossRef Yachha SK, Khanna V (2006) Ascites in childhood liver disease. Indian J Pediatr 73(9):819–824PubMedCrossRef
Zurück zum Zitat Zernikow B, Szybalski K, Hübner-Mohler B et al (2019) Specialized pediatric palliative care services for children dying from cancer: a repeated cohort study on the developments of symptom management and quality of care over a 10-year period. Palliat Med 33(3):381–391PubMedCrossRef Zernikow B, Szybalski K, Hübner-Mohler B et al (2019) Specialized pediatric palliative care services for children dying from cancer: a repeated cohort study on the developments of symptom management and quality of care over a 10-year period. Palliat Med 33(3):381–391PubMedCrossRef
Zurück zum Zitat Zürcher A, Laine ML, Filippi A (2014) Diagnosis, prevalence, and treatment of halitosis. Curr Oral Health Rep 1(4):279–285CrossRef Zürcher A, Laine ML, Filippi A (2014) Diagnosis, prevalence, and treatment of halitosis. Curr Oral Health Rep 1(4):279–285CrossRef
Metadaten
Titel
Gastroenterologische Symptome
verfasst von
Boris Zernikow
Jens Berrang
Carola Hasan
Margit Baumann-Köhler
Michael C. Frühwald
Johannes Holzapfel
Silke Kromm
Thomas Berger
Copyright-Jahr
2022
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-63148-5_3

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