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Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 1/2024

07.09.2023 | Clinical Report

Gene Polymorphism Influencing Persistent Bone Resorption in Brown Tumor: A Case Series with Possible Pathogenesis and Potential Therapeutic Approach

verfasst von: Ayushi Jain, Pooja Sharma, Sivakumar N, Kriti Sharma, Shalini Gupta

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 1/2024

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Abstract

Brown tumor represents a terminal stage of bone remodeling process due to an imbalance between osteoclastic and osteoblastic activity. It represents a reparative cellular process, rather than a neoplastic process mostly associated with primary or secondary hyperparathyroidism. Although parathyroidectomy is the first treatment of choice for brown tumors, several cases don’t resolve even after normalization of parathyroid hormone levels which leads to surgical intervention. Therefore, to avoid multiple bone surgeries in the same patient, it is crucial to have a conservative approach like targeted therapy which could block certain molecules involved in bone resorption. In this string, we have recognized and quantified three molecules namely sclerostin, MCP-1 and CD73 in brown tumors and correlated their expression with bone resorption pathogenesis and potential therapeutic approach.
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Metadaten
Titel
Gene Polymorphism Influencing Persistent Bone Resorption in Brown Tumor: A Case Series with Possible Pathogenesis and Potential Therapeutic Approach
verfasst von
Ayushi Jain
Pooja Sharma
Sivakumar N
Kriti Sharma
Shalini Gupta
Publikationsdatum
07.09.2023
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 1/2024
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-023-04203-4

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