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Current Diabetes Reports

Erschienen in:

01.10.2019 | Genetics (AP Morris, Section Editor)

Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine

verfasst von: Ayo P. Doumatey, Kenneth Ekoru, Adebowale Adeyemo, Charles N. Rotimi

Erschienen in: Current Diabetes Reports | Ausgabe 10/2019

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Abstract

Purpose of Review

Recent advances in genomics provide opportunities for novel understanding of the biology of human traits with the goal of improving human health. Here, we review recent obesity and type 2 diabetes (T2D)–related genomic studies in African populations and discuss the implications of limited genomics studies on health disparity and precision medicine.

Recent Findings

Genome-wide association studies in Africans have yielded genetic discovery that would otherwise not be possible; these include identification of novel loci associated with obesity (SEMA-4D, PRKCA, WARS2), metabolic syndrome (CA-10, CTNNA3), and T2D (AGMO, ZRANB3). ZRANB3 was recently demonstrated to influence beta cell mass and insulin response. Despite these promising results, genomic studies in African populations are still limited and thus genomics tools and approaches such as polygenic risk scores and precision medicine are likely to have limited utility in Africans with the unacceptable possibility of exacerbating prevailing health disparities.

Summary

African populations provide unique opportunities for increasing our understanding of the genetic basis of cardiometabolic disorders. We highlight the need for more coordinated and sustained efforts to increase the representation of Africans in genomic studies both as participants and scientists.

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Titel: Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine
verfasst von: Ayo P. Doumatey
Kenneth Ekoru
Adebowale Adeyemo
Charles N. Rotimi
Publikationsdatum: 01.10.2019
Verlag: Springer US
Erschienen in: Current Diabetes Reports / Ausgabe 10/2019
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-019-1215-5

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Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

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