Background
Methods
Study subjects
DNA extraction
Genotyping
Statistical analysis
Results
Demographic information of the subjects
Characteristics | Cases (n = 405) | Controls (n = 405) |
P
| ||
---|---|---|---|---|---|
n | % | n | % | ||
Age (year; mean ± SD) | 60.89 ± 7.83 | 60.93 ± 7.91 | 0.87a | ||
Gender | |||||
Male | 240 | 59.26 | 240 | 59.26 | - |
Female | 165 | 40.74 | 165 | 40.74 | |
Tobacco smoking | |||||
Ever | 183 | 45.19 | 171 | 42.22 | 0.43b |
Never | 222 | 54.81 | 234 | 57.78 | |
Alcohol consumption | |||||
Ever | 117 | 28.89 | 96 | 23.70 | 0.11b |
Never | 288 | 71.11 | 309 | 76.30 |
Correlation of NAMPT genotypes and alleles with ESCC susceptibility
Genotype | Cases (n = 405) | Controls (n = 405) |
P
a
| ORa(95% CI) | ||
---|---|---|---|---|---|---|
n | % | n | % | |||
rs61330082 | ||||||
CC | 132 | 32.59 | 66 | 16.30 | 1.00 | 1.00 |
CT | 198 | 48.89 | 216 | 53.33 | <0.01 | 0.47 (0.33-0.68) |
TT | 75 | 18.52 | 123 | 30.37 | <0.01 | 0.33 (0.22-0.50) |
C Allele | 462 | 57.04 | 348 | 42.96 | 1.00 | 1.00 |
T Allele | 348 | 42.96 | 462 | 57.04 | <0.01 | 0.48 (0.38-0.61) |
rs2505568 | ||||||
TT | 168 | 41.48 | 171 | 42.22 | 1.00 | 1.00 |
AT | 237 | 58.82 | 234 | 57.78 | 0.91 | 1.02 (0.77-1.34) |
AA | 0 | 0.00 | 0 | 0.00 | - | - |
T Allele | 573 | 70.74 | 576 | 71.11 | 1.00 | 1.00 |
A Allele | 237 | 29.26 | 234 | 28.89 | 0.92 | 1.02 (0.77-1.34) |
rs9034 | ||||||
TT | 0 | 0.00 | 0 | 0.00 | - | - |
CT | 51 | 12.59 | 36 | 8.89 | 1.00 | 1.00 |
CC | 354 | 87.41 | 369 | 91.11 | 0.09 | 0.64 (0.38-1.07) |
T Allele | 51 | 6.30 | 36 | 4.44 | 1.00 | 1.00 |
C Allele | 759 | 93.70 | 774 | 95.56 | 0.13 | 0.70 (0.45-1.10) |
Correlation of NAMPT haplotypes with ESCC susceptibility
Haplotypes | SNP positions | Cases (n = 405) | Controls (n = 405) | ||||
---|---|---|---|---|---|---|---|
rs6133082 | rs2505568 | rs9034 | n | %a | n | %a | |
a | T | T | C | 238 | 29.39 | 294 | 36.26 |
b | T | A | C | 107 | 13.21 | 158 | 19.47 |
c | C | T | C | 293 | 36.17 | 250 | 30.91 |
d | C | T | T | 39 | 4.81 | 24 | 2.94 |
e | C | A | C | 121 | 14.92 | 72 | 8.92 |
Haplotype | Cases (n = 405) | Controls (n = 405) |
P
a
| ORa(95% CI) | ||
---|---|---|---|---|---|---|
n | % | n | % | |||
a = TTC | ||||||
−/−b | 258 | 63.70 | 204 | 50.37 | 1.00 | 1.00 |
-/a + a/a | 147 | 36.30 | 201 | 49.63 | <0.01 | 0.61 (0.46-0.79) |
b = TAC | ||||||
−/− | 237 | 58.52 | 195 | 48.15 | 1.00 | 1.00 |
-/b + b/b | 168 | 41.48 | 210 | 51.85 | <0.01 | 0.69 (0.52-0.90) |
c = CTC | ||||||
−/− | 111 | 27.41 | 147 | 36.30 | 1.00 | 1.00 |
-/c + c/c | 294 | 72.59 | 258 | 63.70 | <0.01 | 1.57 (1.16-2.12) |
d = CTT | ||||||
−/− | 354 | 87.41 | 372 | 91.85 | 1.00 | 1.00 |
-/d + d/d | 51 | 12.59 | 33 | 8.15 | 0.04 | 1.72 (1.03-2.85) |
e = CAC | ||||||
−/− | 336 | 82.96 | 381 | 94.07 | 1.00 | 1.00 |
-/e + e/e | 69 | 17.04 | 24 | 5.93 | <0.01 | 3.39 (1.99-5.75) |