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International Journal of Clinical Oncology

Erschienen in:

01.10.2013 | Original Article

Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma

verfasst von: Kei Horino, Toru Beppu, Hideyuki Kuroki, Kosuke Mima, Hirohisa Okabe, Osamu Nakahara, Yoshiaki Ikuta, Akira Chikamoto, Takatoshi Ishiko, Hiroshi Takamori, Hideo Baba

Erschienen in: International Journal of Clinical Oncology | Ausgabe 5/2013

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Abstract

Background

Several previous studies have revealed that the Glasgow Prognostic Score (GPS) is a clinically useful scoring system to predict the prognosis of patients with various kinds of advanced cancers. However, there have been few reports on the relationship between the GPS and prognosis after hepatectomy for hepatocellular carcinoma (HCC). Therefore, we performed an analysis of the relationship between the GPS and prognosis after hepatectomy for HCC.

Methods

Between January 2005 and December 2009, 352 HCC patients underwent hepatectomy at Kumamoto University Hospital. Nineteen clinicopathologic factors were analyzed, using univariate and multivariate analyses.

Results

Univariate analysis showed that significant risk factors for poor survival included serum albumin level (<3.5 g/dL), tumor size (>35 mm), presence of ascites, portal vein invasion, operation time (>400 min), blood loss (>360 mL), requirement for blood transfusion, and GPS. Multivariate analysis revealed that tumor size [hazard ratio (HR) 3.355; p = 0.003], operation time (HR 2.634; p = 0.006), portal vein invasion (HR 2.419; p = 0.009), and GPS (HR 3.796; p < 0.001) were independent factors for poor prognosis.

Conclusion

The GPS was demonstrated to be a statistically significant prognostic factor after hepatectomy for HCC.

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Titel: Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma
verfasst von: Kei Horino
Toru Beppu
Hideyuki Kuroki
Kosuke Mima
Hirohisa Okabe
Osamu Nakahara
Yoshiaki Ikuta
Akira Chikamoto
Takatoshi Ishiko
Hiroshi Takamori
Hideo Baba
Publikationsdatum: 01.10.2013
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 5/2013
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-012-0451-3

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Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma