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International Journal of Clinical Oncology

Erschienen in:

01.10.2013 | Original Article

High Ran level is correlated with poor prognosis in patients with colorectal cancer

verfasst von: Hongwei Fan, Yuanyuan Lu, Hai Qin, Yi Zhou, Yong Gu, Jinfeng Zhou, Xin Wang, Daiming Fan

Erschienen in: International Journal of Clinical Oncology | Ausgabe 5/2013

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Abstract

Background

The Ras-like nuclear protein (Ran) is involved in the regulation of nuclear transport, microtubule nucleation and dynamics, and spindle assembly. Its fundamental function is nucleocytoplasmic transport of RNA and proteins. The expression and potential role of Ran in colorectal cancer (CRC) remain unclear. The aim of this study was to investigate the relationship between Ran expression and CRC characteristics. The potential role of Ran as a prognostic indicator was also evaluated.

Methods

We used immunohistochemistry and western blotting to detect Ran expression in 287 CRC tissues. The relationships between Ran expression and clinicopathological characteristics and overall survival rate were statistically analyzed.

Results

CRC tissues had significantly higher Ran expression than normal colorectal epithelial cells. Ran was positively correlated with depth of invasion, lymph node metastases, distant metastases, tumor differentiation, and tumor–node–metastasis stage. However, no correlation was found between Ran expression and patient age or sex. The overall survival rate was consistently and significantly lower in patients with Ran-positive tumors than in those with Ran-negative tumors.

Conclusion

Our findings emphasize the important role of Ran in differentiation, disease stage, and metastasis in human CRC. Ran may play an important role in the development of CRC and may serve as a novel prognostic indicator of CRC.

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Titel: High Ran level is correlated with poor prognosis in patients with colorectal cancer
verfasst von: Hongwei Fan
Yuanyuan Lu
Hai Qin
Yi Zhou
Yong Gu
Jinfeng Zhou
Xin Wang
Daiming Fan
Publikationsdatum: 01.10.2013
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 5/2013
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-012-0465-x

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Springer Medizin

High Ran level is correlated with poor prognosis in patients with colorectal cancer

Abstract

Background

Methods

Results

Conclusion

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Abstract

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Conclusion

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