Erschienen in:
01.12.2001 | Paper Report
Glucosamine treatment of osteoarthritis of the knee
verfasst von:
Richard Brasington
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The functions of articular cartilage are dependent upon aggrecan, the predominant proteoglycan, and hyaluronan, which is composed of repeating glycosaminoglycan units of N-acetylglucosamine and glucuronic acid. Both hyaluronan and aggrecan are degraded in osteoarthritic cartilage. Use of glucosamine as a treatment of osteoarthritis has become widespread, despite the lack of evidence supporting its efficacy. This study tests the hypothesis that oral administration of glucosamine sulfate relieves symptoms and delays radiographic progression of osteoarthritis of the knee. …