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01.09.2005

Glucose Intolerance Modifies the Inflammatory Response After Intestinal Ischemia-Reperfusion

verfasst von: Juan C. Garcia-Perez, M.D., Ph.D., Javier Arias-Diaz, M.D., Ph.D., Elena Vara, Ph.D., Jose L. Balibrea, M.D., Ph.D.

Erschienen in: World Journal of Surgery | Ausgabe 9/2005

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Abstract

Streptozotocin administration in newborn rats (nSTZ-rats) leads to adults with mild insulin deficiency and normoglycemia, and is accepted as a model of type 2 diabetes. We examined possible differences in the production of inflammatory mediators between healthy and nSTZ-rats after ischemia-reperfusion (I-R). Two-month-old control and nSTZ-rats were randomly separated into control and intestinal I-R groups. After reperfusion, samples were obtained from the portal vein (PV) infrahepatic cava vein (ICV), suprahepatic cava vein (SCV), jejunal wall, and pancreas. Nitric oxide (NO), lipid hydroperoxides (LPO), tumor necrosis factor alpha (TNF-α), 60 kDa receptor (sTNF-R1), 80 kDa (sTNF-R2), and intercellular adhesion molecule-1 (ICAM-1), were determined. After I-R, nSTZ-rats showed increased plasma concentrations of LPO, NO, ICAM-1 (0.5141 ± 0.083 vs 0.024 ± 0.003, ICV; 0.574 ± 0.075 vs 0.023 ± 0.003, SCV; 0.528 ± 0.067 vs 0.027 ± 0.003 PV; ng/ml), TNF-α (42.4 ± 5.7 ICV, 248.4 ± 28.2 SCV, and 33.6 ± 4.0 PV. In n STZ-rats, vs 4.36 ± 0.57, 4.74 ± 0.77, and 3.16 ± 0.32, respectively, in control rats; pg/ml), and sTNF-R1. Both TNF-α and NO plasma levels were higher in SCV than in ICV and PV after I-R. In addition, after I-R, jejunal wall of nSTZ-rats showed an increase of TNF-α IL-1, and IL-10 levels. A pre-existing state of glucose intolerance intensifies the inflammatory response after intestinal I-R.

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Titel: Glucose Intolerance Modifies the Inflammatory Response After Intestinal Ischemia-Reperfusion
verfasst von: Juan C. Garcia-Perez, M.D., Ph.D.
Javier Arias-Diaz, M.D., Ph.D.
Elena Vara, Ph.D.
Jose L. Balibrea, M.D., Ph.D.
Publikationsdatum: 01.09.2005
Verlag: Springer-Verlag
Erschienen in: World Journal of Surgery / Ausgabe 9/2005
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-005-7700-9

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