Background
Methods
Patients
Patient characteristics and clinicopathological features
Variable | n | % | GRP78 |
P
| HPA |
P
| ||
---|---|---|---|---|---|---|---|---|
Positive
|
Negative
|
Positive
|
Negative
| |||||
Tissue
|
0.003
|
0.033
| ||||||
Normal | 10 | 17.9 | 0 | 10 | 0 | 10 | ||
OSCC | 46 | 82.1 | 27 | 19 | 19 | 27 | ||
Gender
|
0.358
|
0.555
| ||||||
Male | 37 | 80.4 | 20 | 17 | 14 | 23 | ||
Female | 9 | 19.6 | 7 | 2 | 5 | 4 | ||
Age
|
0.606
|
0.055
| ||||||
≤60 | 27 | 58.7 | 15 | 12 | 8 | 19 | ||
>60 | 19 | 41.3 | 12 | 7 | 11 | 8 | ||
Tumor size
|
0.001
|
0.036
| ||||||
≤3.1 | 23 | 50.0 | 8 | 15 | 6 | 17 | ||
>3.1 | 23 | 50.0 | 19 | 4 | 13 | 10 | ||
Tumor stage
|
0.001
|
0.000
| ||||||
T1-T2 | 31 | 67.4 | 13 | 18 | 7 | 24 | ||
T3-T4 | 15 | 32.6 | 14 | 1 | 12 | 3 | ||
Lymphatic metastasis
|
0.000
|
0.012
| ||||||
N0 | 27 | 58.7 | 10 | 17 | 7 | 20 | ||
N1-3 | 19 | 41.3 | 17 | 2 | 12 | 7 | ||
Distant metastasis
|
0.033
|
0.000
| ||||||
M0 | 35 | 76.1 | 17 | 18 | 8 | 27 | ||
M1 | 11 | 23.9 | 10 | 1 | 11 | 0 | ||
TNM stage
|
0.000
|
0.000
| ||||||
I-II | 23 | 50.0 | 6 | 17 | 3 | 20 | ||
III-IV | 23 | 50.0 | 21 | 2 | 16 | 7 | ||
Histologic grade
|
0.018
|
0.016
| ||||||
G1-G2 | 12 | 26.1 | 11 | 1 | 9 | 3 | ||
G3-G4 | 34 | 73.9 | 16 | 18 | 10 | 24 | ||
Cigarette smoking
|
0.246
|
0.180
| ||||||
Yes | 39 | 84.8 | 21 | 18 | 14 | 25 | ||
No | 7 | 15.2 | 6 | 1 | 5 | 2 | ||
Alcohol drinking
|
0.787
|
1.000
| ||||||
Yes | 36 | 78.3 | 22 | 14 | 15 | 21 | ||
No | 10 | 21.7 | 5 | 5 | 4 | 6 |
Reagents
Immunohistochemistry
Evaluation of slides
Statistical analysis
Results
GRP78 and HPA expression in oral squamous cell carcinoma and normal tissue
Correlations between GRP78 expression in oral squamous cell carcinoma and clinicopathological parameters
Correlation between HPA expression in oral squamous cell carcinoma and clinicopathological parameters
Correlations between GRP78 and HPA expression
Variables | GRP78 | r |
P
| |
---|---|---|---|---|
Positive
|
Negative
| |||
HPA | 0.435 | 0.003 | ||
Positive | 19 | 0 | ||
Negative | 8 | 19 |
Prognosis and multivariate analysis
Risk factors | RR | 95% CI |
P
|
---|---|---|---|
age
|
0.049
|
0. 007-0. 329
|
0. 002
|
Distant metastasis
|
7.566
|
1.243-46.049
|
0. 028
|
GRP78
|
0.023
|
0.002-0.239
|
0.002
|
HPA
|
0.08
|
0.001-0.110
|
0.000
|