Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Pediatric Nephrology
Erschienen in: Pediatric Nephrology 4/2010

01.04.2010 | Review

Growth-plate cartilage in chronic renal failure

verfasst von: Cheryl P. Sanchez

Erschienen in: Pediatric Nephrology | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Bone growth occurs in the growth-plate cartilage located at the ends of long bones. Changes in the architecture, abnormalities in matrix organization, reduction in protein staining and RNA expression of factors involved in cell signaling have been described in the growth-plate cartilage of nephrectomized animals. These changes can lead to a smaller growth plate associated with decrease in chondrocyte proliferation, delayed hypertrophy, and prolonged initiation of mineralization and vascular invasion. As a result, chronic renal failure can result in stunted body growth and skeletal deformities. Multiple etiologic factors can contribute to impaired bone growth in renal failure, including suboptimal nutrition, metabolic acidosis, and secondary hyperparathyroidism. Recent findings have also shown the tight connection between chondro/osteogenesis, hematopoiesis, and immunogenesis.
Literatur
1.
Abad V, Meyers JL, Weise M, Gafni RI, Barnes KM, Nilsson O, Bacher JD, Baron J (2002) The role of the resting zone in growth plate chondrogenesis. Endocrinology 143:1851–1857CrossRefPubMed
2.
Vortkamp A, Lee K, Lankse B, Segre GV, Kronenberg HM, Tabin CJ (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273:613–622CrossRefPubMed
3.
4.
Alvarez J, Sohn P, Zeng X, Doetschman T, Robbins D, Serra R (2002) TGFβ2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development 129:1913–1924PubMed
5.
MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM (2004) The cyclin-dependent kinase inhibitor p57Kip2 mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest 113:1334–1343PubMed
6.
Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VLJ, Kronenberg HM, Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8:277–289CrossRefPubMed
7.
Amizuka N, Warshawsky H, Henderson JE, Goltzman D, Karaplis AC (1994) Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J Cell Biol 126:1611–1623CrossRefPubMed
8.
Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE (1996) Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93:10240–10245CrossRefPubMed
9.
Zhang M, Xie R, Hou W, Wang B, Shen R, Wang X, Wang Q, Zhu T, Jonason J, Chen D (2009) PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. J Cell Sci 122:1382–1389CrossRefPubMed
10.
Dong Y, Soung YD, Schwarz E, O'Keefe R, Drissi H (2006) Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol 208:77–86CrossRefPubMed
11.
Yoshida C, Komori T (2005) Role of Runx proteins in chondrogenesis. Crit Rev Eukaryot Gene Expr 15:243–254PubMed
12.
Komori T (2005) Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem 95:445–453CrossRefPubMed
13.
Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T (2004) Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166:85–95CrossRefPubMed
14.
Enomoto H, Shiojiri S, Hoshi K, Furuichi T, Fukuyama R, Yoshida C, Kanatani N, Nakamura R, Mizuno A, Zanno A, Yano K, Yasuda H, Higashio K, Takada K, Komori T (2003) Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene. J Biol Chem 278:23971–23977CrossRefPubMed
15.
Hunziker EB, Kapfinger E, Saager C (1999) Hypertrophy of growth plate chondrocytes in vivo is accompanied by modulations in the activity state and surface area of their cytoplasmic organelles. Histochem Cell Biol 112:115–123CrossRefPubMed
16.
Reinecke M, Schmid AC, Heyberger-Meyer B, Hunziker EB, Zapf J (2000) Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo. Endocrinology 141:2847–2853CrossRefPubMed
17.
Srinivas V, Bohensky J, Shapiro IM (2009) Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase. Cells Tissues Organs 189:88–92CrossRefPubMed
18.
Li J, Sarosi I, Yan X-Q, Morony S, Capparelli C, Tan H-L, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan S-C, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ (2000) RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 97:1566–1571CrossRefPubMed
19.
Zelzer E, Mamluk R, Ferrara N, Johnson R, Schipani E, Olsen B (2006) VEGFA is necessary for chondrocyte survival during bone development. Development 131:2161–2171CrossRef
20.
Stricker S, Fundele R, Vortkamp A, Mundlos S (2002) Role of Runx genes in chondrocyte differentiation. Dev Biol 245:95–108CrossRefPubMed
21.
Hofbauer L, Heufelder A (2001) Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 79:243–253CrossRefPubMed
22.
Walsh M, Kim N, Kadono Y, Rho J, Lee S, Lorenzo J, Choi Y (2006) Osteoimmunology: interplay between the immune system and bone metabolism. Ann Rev Immunol 24:33–63CrossRef
23.
Sharma AP, Sharma RK, Kapoor R, Kornecki A, Sural S, Filler G (2007) Incomplete distal renal tubular acidosis affects growth in children. Nephrol Dial Transplant 22:2879–2885CrossRefPubMed
24.
Challa A, Krieg RJ, Thabet MA, Veldhuis JD, Chan JC (1993) Metabolic acidosis inhibits growth hormone secretion in rats: mechanism of growth retardation. Am J Physiol 265:E547–E553PubMed
25.
Goldberg R, Reshef-Bankai E, Coleman R, Green J, Maor G (2006) Chronic acidosis-induced growth retardation is mediated by proton-induced expression of Gs protein. J Bone Miner Res 215:703–713CrossRef
26.
Green J, Maor G (2000) Effect of metabolic acidosis on the growth hormone/IGF-I endocrine axis in skeletal growth centers. Kidney Int 57:2258–2267CrossRefPubMed
27.
Waldman S, Couto D, Omelon S, Kandel R (2004) Effect of sodium bicarbonate on extracellular pH, matrix accumulation, and morphology of cultured articular chondrocytes. Tissue Eng 10:1633–1640CrossRefPubMed
28.
Wu M, Urban J, Cui Z, Xu X (2007) Effect of extracellular ph on matrix synthesis by chondrocytes in 3D agarose gel. Biotechnol Prog 23:430–434CrossRefPubMed
29.
Jandziszak K, Suarez C, Saenger PH, Brion LP (2000) Time course of the response to recombinant growth hormone in acidotic mice. Pediatr Nephrol 14:922–926CrossRefPubMed
30.
Gat-Yablonski G, Shtaif B, Abraham E, Phillip M (2008) Nutrition-induced catch-up growth at the growth plate. J Pediatr Endocrinol Metab 21:879–893PubMed
31.
Farnum CA, Lee AO, O'Hara K, Wilsman NJ (2003) Effect of short-term fasting on bone elongation rates: an analysis of catch-up growth in young male rats. Pediatr Res 53:33–41PubMed
32.
Molinos I, Santos F, Carbajo-Perez E, Garcia E, Rodriguez J, Garcia-Alvarez O, Gil H, Ordonez FA, Loredo V, Mallada L (2006) Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it. Kidney Int 70:1955–1961PubMed
33.
Gevers E, Hannah M, Waters M, Robinson I (2009) Regulation of rapid stat5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding. Endocrinology 150:3627–3636CrossRef
34.
Schaefer F, Chen Y, Tsao T, Nouri P, Rabkin R (2001) Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia. J Clin Invest 108:467–475PubMed
35.
Ram PA, Waxman DJ (1999) SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 274:35553–35561CrossRefPubMed
36.
Tollet-Egnell P, Flores-Morales A, Stavreus-Evers A, Sahlin L, Norstedt G (1999) Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat. Endocrinology 140:3693–3704CrossRefPubMed
37.
Gat-Yablonski G, Ben-Ari T, Shtaif B, Potievsky O, Moran O, Eshet R, Maor G, Segev Y, Phillip M (2004) Leptin reverses the inhibitory effect of caloric restriction on longitudinal growth. Endocrinology 145:343–350CrossRefPubMed
38.
Arbeiter A, Buscher R, Petersenn S, Hauffa B, Mann K, Hoyer PF (2009) Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation. Nephrol Dial Transplant 24:643–646CrossRefPubMed
39.
Cobo A, Lopez JM, Carbajo E, Santos F, Alvarez J, Fernandez M, Weruaga A (1999) Growth plate cartilage formation and resorption are differentially expressed in growth retarded uremic rats. J Am Soc Nephrol 10:971–979PubMed
40.
Sanchez C, He Y, Leiferman E, Wilsman N (2004) Bone elongation in rats with renal failure and mild or advanced secondary hyperparathyroidism. Kidney Int 65:1740–1748CrossRefPubMed
41.
Sanchez C, He Y (2007) Bone growth during daily or intermittent calcitriol treatment during renal failure with advanced secondary hyperparathyroidism. Kidney Int 72:582–591CrossRefPubMed
42.
Alvarez J, Balbin M, Fernandez M, Lopez JM (2001) Collagen metabolism is markedly altered in the hypertrophic cartilage of growth plates from rats with growth impairment secondary to chronic renal failure. J Bone Miner Res 16:511–524CrossRefPubMed
43.
Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R (2005) Loss of α10β1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci 118:929–936CrossRefPubMed
44.
Hopper T, Wehrli FW, Saha P, Andre J, Wright A, Sanchez C, Leonard M (2007) Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy. J Comput Assist Tomogr 31:320–328CrossRefPubMed
45.
Yano S, Sugimoto T, Tsukamoto T, Chihara K, Kobayashi A, Kitazawa S, Maeda S, Kitazawa R (2003) Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas. Eur J Endocrinol 148:403–411CrossRefPubMed
46.
Masuyama R, Stockmans I, Torrekens S, Looveren RV, Maes C, Carmeliet P, Bouillon R, Carmeliet G (2006) Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116:3150–3159CrossRefPubMed
47.
Chang W, Tu C, Chen T, Bikle D, Shoback D (2008) The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1:ra1CrossRefPubMed
48.
Canadillas S, Canalejo A, Santamaria R, Rodriguez ME, Estepa JC, Martin-Malo A, Bravo J, Ramos B, Aguilera-Tejero E, Rodriguez M, Almaden Y (2005) Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans. J Am Soc Nephrol 16:2190–2197CrossRefPubMed
49.
Nakagawa K, Perez E, Oh J, Santos F, Geldyyev A, Gross M, Schaefer F, Schmitt C (2008) Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. Nephrol Dial Transplant 23:2761–2767CrossRefPubMed
50.
Muscheites J, Wigger M, Drueckler E, Fischer D, Kundt G, Haffner D (2008) Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease. Pediatr Nephrol 23:1823–1829CrossRefPubMed
51.
Silverstein D, Kher K, Moudgil A, Khurana M, Wilcox J, Moylan K (2008) Cinacalcet is efficacious in pediatric dialysis patients. Pediatr Nephrol 23:1817–1822CrossRefPubMed
52.
Kolek O, Hines E, Jones M, LeSueur L, Lipko M, Kiela P, Collins J, Haussler M, Ghishan F (2005) 1α, 25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 289:G1036–G1042CrossRefPubMed
53.
Strom T, Jüppner H (2008) PHEX, FGF23, DMP1 and beyond. Curr Opin Nephrol Hypertens 17:357–362CrossRefPubMed
54.
Julien M, Khoshniat S, Lacreusette A, Gatius M, Bozec A, Wagner E, Wittrant Y, Masson M, Weiss P, Beck L, Magne D, Guicheux J (2009) Phosphate-dependent regulation of MGP in osteoblasts: Role of ERK1/2 and Fra-1. J Bone Miner Res. doi:10.​1359/​jbmr.​090508 PubMed
55.
Wesseling-Perry K, Pereira R, Wang H, Elashoff RM, Sahney S, Gales B, Jüppner H, Salusky IB (2009) Relationship between plasma FGF-23 concentration and bone mineralization in children with renal failure on peritoneal dialysis. J Clin Endocrinol Metab 94:511–517CrossRefPubMed
56.
57.
58.
Neves P, Trivino J, Casaubon F, Santos V, Mendes P, Romao P, Bexiga I, Bernardo I (2006) Elderly patients on chronic hemodialysis with hyperparathyroidism: increase of hemoglobin level after intravenous calcitriol. Int Urol Nephrol 38:175–177CrossRefPubMed
59.
Lin C, Hung C, Yang C, Huang C (2004) Improved anemia and reduced erythropoietin need by medical or surgical intervention of secondary hyperparathyroidism in hemodialysis patients. Ren Fail 26:289–295CrossRefPubMed
60.
Sweeney E, Campbell M, Watkins K, Hunter C, Jacenko O (2008) Altered endochondral ossification in collagen X mouse models leads to impaired immune responses. Dev Dyn 237:2693–2704CrossRefPubMed
61.
Jacenko O, Roberts DW, Campbell MR, McManus PM, Gress CJ, Tao Z (2002) Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. Am J Pathol 160:2019–2034PubMed
Metadaten
Titel
Growth-plate cartilage in chronic renal failure
verfasst von
Cheryl P. Sanchez
Publikationsdatum
01.04.2010
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 4/2010
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-009-1307-6

Weitere Artikel der Ausgabe 4/2010

Pediatric Nephrology 4/2010 Zur Ausgabe

Review

Effects of steroid avoidance and novel protocols on growth in paediatric renal transplant patients

Review

Inflammation and cachexia in chronic kidney disease

Letter to the Editors

Two cases of swine H1N1 influenza presenting with hematuria as prodrome

Review

New therapies: calcimimetics, phosphate binders and vitamin D receptor activators

Review

Effects of GH in human muscle and fat

Review

Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy

Neu im Fachgebiet Pädiatrie

Klimaschutz beginnt bei der Wahl des Inhalators

14.05.2024 Klimawandel Podcast

Auch kleine Entscheidungen im Alltag einer Praxis können einen großen Beitrag zum Klimaschutz leisten. Die neue Leitlinie zur "klimabewussten Verordnung von Inhalativa" geht mit gutem Beispiel voran, denn der Wechsel vom klimaschädlichen Dosieraerosol zum Pulverinhalator spart viele Tonnen CO2. Leitlinienautor PD Dr. Guido Schmiemann erklärt, warum nicht nur die Umwelt, sondern auch Patientinnen und Patienten davon profitieren.

Zeitschrift für Allgemeinmedizin, DEGAM

Embryotransfer erhöht womöglich Leukämierisiko der Kinder

13.05.2024 Assistierte Reproduktion Nachrichten

Reproduktionsmedizinische Techniken haben theoretisch das Potenzial, den epigenetischen Code zu verändern und somit das Krebsrisiko der Kinder zu erhöhen. Zwischen Embryotransfer und Leukämie scheint sich ein solcher Zusammenhang bestätigt zu haben.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise