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World Journal of Surgery

Erschienen in:

04.02.2019 | Original Scientific Report

Health-Related Quality of Life Associated with Barrett’s Esophagus and Cancer

verfasst von: Norma B. Bulamu, Gang Chen, Julie Ratcliffe, Ann Schloite, Tim Bright, David I. Watson

Erschienen in: World Journal of Surgery | Ausgabe 6/2019

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Abstract

Background

Research assessing health-related quality of life (HRQoL) which can be applied to economic evaluation in Barrett’s esophagus (BE) and esophageal cancer is limited. This study derived health state utilities for various ‘stages’ of BE and Cancer.

Methods

A cross-sectional survey was conducted, including patients with non-dysplastic BE, low-grade dysplasia, high-grade dysplasia, or esophageal adenocarcinoma. HRQoL was assessed using generic instruments—EQ-5D-5L and SF-36, and a cancer-specific instrument—EORTC QLQ-C30. Outcomes were compared for health states following different treatments. Correlations and agreements for the three instruments were investigated using Spearman’s correlation coefficient (r) and intraclass correlation coefficient (ICC).

Results

A total of 97 respondents (80% male, mean age 68 years) returned questionnaires. The mean (standard deviation) health state utilities for the total sample were 0.79 (0.24) for the EQ-5D-5L, 0.57 (0.29) for the SF-6D (derived from SF-36) and 0.73 (0.20) for the QLU-C10D (derived from EORTC QLQ-C30). There were strong correlations (r > 0.80) and absolute agreement (except EQ-5D-5L and SF-6D with an ICC of 0.69) among the three instruments. No significant differences were observed for different stages of BE or interventions. However, following surgery for cancer patients reported better psychological well-being than those under surveillance or following endoscopic treatments.

Conclusion

HRQoL for BE surveillance and following cancer treatment was similar. Esophagectomy was associated with better psychological functioning, and this might be attributed to a reduction in the perceived risk of cancer. The correlation between the EORTC QLU-C10D and the other health state utility instruments supports the validity of this new instrument.

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Titel: Health-Related Quality of Life Associated with Barrett’s Esophagus and Cancer
verfasst von: Norma B. Bulamu
Gang Chen
Julie Ratcliffe
Ann Schloite
Tim Bright
David I. Watson
Publikationsdatum: 04.02.2019
Verlag: Springer International Publishing
Erschienen in: World Journal of Surgery / Ausgabe 6/2019
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-019-04936-w

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Abstract

Background

Methods

Results

Conclusion

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