Background
Methods
Study patients and design
Demographic and clinical data
Assessment of HRQOL
Statistical analyses
Results
Clinical and demographic characteristics
RG + (n = 50) | RG – (n = 251) | p level | |
---|---|---|---|
Female gender
| 23/50 | 79/250 | 0.05 |
Age years
| 50.3 (16.6) | 61.7 (15.5) | < 0.001 |
Systolic blood pressure mmHg
| 137 (23) | 142 (21) | 0.12 |
Diastolic blood pressure mmHg
| 79 (15) | 77 (12) | 0.46 |
Body mass index kg/m
2
| 21.5 (20 - 25) | 24.8 (22 - 28) | < 0.001 |
Hemoglobin g/dL
| 12.2 (1.5) | 12.1 (1.5) | 0.66 |
Albumin g/L
| 37.4 (4.7) | 38.4 (5.0) | 0.19 |
CRP mmol/L
| 8 (2 - 13) | 6.0 (2 - 13) | 0.92 |
Cholesterol mmol/L
| 4.7 (1.3) | 4.2 (1.3) | 0.01 |
PTH pmol/L
| 25 (12 - 51) | 24 (13 - 40) | 0.61 |
Urea mmol/L
| 23 (7) | 22 (6) | 0.18 |
Charlson comorbidity index
*
| 3 (2 - 4) | 4 (2 - 5) | 0.08 |
Dialysis vintage months
| 13 (5 - 28)†
| 10 (5 - 23) | 0.52 |
Nephrosclerosis
| 3/48 | 76/248 | < 0.001 |
Waiting listed
| 25/50 | 97/250 | 0.14 |
Effect of gender and graft loss on HRQOL
KDQOL-SF36 | RG + (n = 50) | RG – (n = 251) | p value |
---|---|---|---|
KDQOL:
| |||
Symptoms
| 71 (25 - 100) | 75 (63 - 85) | 0.24 |
Effect of kidney disease
| 56 (44 - 78) | 69 (56 - 81) | 0.01 |
Burden of kidney disease
| 31 (19 - 51) | 31 (19 - 50) | 0.84 |
Work status
| 0 (0 - 0) | 0 (0 - 38) | 0.43 |
Cognitive function
| 87 (67 - 93) | 93 (80 - 100) | 0.04 |
Quality of social interaction
| 90 (73 - 100) | 87 (67 - 100) | 0.49 |
Sexual functioning
| 63 (25 - 100) | 62 (31 - 94) | 0.99 |
Sleep
| 60 (46 - 78) | 65 (48 - 80) | 0.41 |
Social support
| 83 (67 - 100) | 83 (67 - 100) | 0.43 |
Staff encouragement
| 88 (75 - 100) | 88 (75 - 100) | 0.71 |
Patient satisfaction with care
| 83 (67 - 100) | 83 (67 - 100) | 0.26 |
SF 36:
| |||
Physical function
| 55 (30 - 83) | 58 (30 - 78) | 0.65 |
Physical role limitations
| 0 (0 - 50) | 0 (0 - 50) | 0.56 |
Bodily pain
| 47 (32 - 77) | 52 (41 - 84) | 0.23 |
General health
| 35 (20 - 55) | 42 (30 - 62) | 0.06 |
Vitality
| 45 (24 - 55) | 45 (30 - 60) | 0.39 |
Social function
| 69 (38 - 88) | 75 (50 - 88) | 0.64 |
Emotional role limitations
| 33(0 - 100) | 67 (0 - 100) | 0.98 |
Mental health
| 72 (60 - 88) | 80 (64 - 88) | 0.30 |
PCS* | 37 (± 12) | 37 (± 19) | 0.95 |
MCS
†
| 46 (± 11) | 48 (± 11) | 0.44 |
FEMALE GENDER (n = 90) | Effect kidney disease | Physical function | Cognitive function | General health | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
R2 = 0.29, p <0.001 | R2= 0.27, p < 0.001 | R2= 0.15, p = 0.03 | R2= 0.18, p = 0.009 | |||||||||
β | t | p | β | t | p | β | t | p | β | t | p | |
Graft loss yes/no | -14.55 | -2.49 | 0.015 | -17.8 | -2.59 | 0.01 | -11.65 | -2.41 | 0.018 | -12.38 | -2.04 | 0.045 |
Age +1 year | 0.42 | 2.70 | 0.009 | -0.50 | -2.69 | 0.009 | 0.20 | 1.55 | 0.13 | 0.21 | 1.31 | 0.20 |
Comorbidity* +1 point | -4.75 | -3.34 | 0.001 | -5.85 | -3.51 | 0.001 | -1.22 | -1.03 | 0.31 | -4.28 | -2.89 | 0.005 |
BMI† ≥ 25.0 kg/m2 yes/no | 6.69 | 1.42 | 0.16 | -0.45 | -0.08 | 0.94 | 5.43 | 1.40 | 0.17 | 7.76 | 1.59 | 0.12 |
Dialysis vintage‡ ≥ 10 months yes/no | -2.56 | -0.52 | 0.61 | 0.54 | -0.09 | 0.93 | 0.35 | 0.09 | 0.93 | 3.91 | 0.77 | 0.45 |
Nephrosclerosis yes/no | -8.83 | -1.40 | 0.17 | -10.66 | -1.44 | 0.15 | -9.39 | -1.79 | 0.08 | -12.50 | -1.90 | 0.06 |
MALE GENDER (n = 197)
|
Effect kidney disease
|
Physical function
|
Cognitive function
|
General health
| ||||||||
R
2
= 0.17, p < 0.001
|
R
2
= 0.23 p < 0.001
|
R
2
= 0.06 p = 0.11
|
R
2
= 0.16, p<0.001
| |||||||||
β
|
t
|
p
|
β
|
t
|
p
|
β
|
t
|
p
|
β
|
t
|
p
| |
Graft loss yes/no | 2.33 | 0.59 | 0.56 | 3.04 | 0.55 | 0.58 | 2.63 | 0.70 | 0.49 | -1.67 | -0.37 | 0.71 |
Age +1 year | 0.38 | 4.28 | <0.001 | -0.49 | -3.98 | <0.001 | 0.25 | 2.93 | 0.004 | 0.24 | 2.42 | 0.016 |
Comorbidity* +1 point | -2.12 | -2.74 | 0.007 | -4.03 | -3.74 | <0.001 | 0.34 | 0.46 | 0.65 | -4.04 | -4.63 | >0.001 |
BMI† ≥ 25.0 kg/m2 yes/no | 7.46 | 2.84 | 0.005 | -0.08 | -0.02 | 0.98 | 1.49 | 0.60 | 0.55 | 3.62 | 1.22 | 0.23 |
Dialysis vintage‡ ≥ 10 months yes/no | -5.83 | -2.19 | 0.03 | -8.52 | -2.30 | 0.02 | -1.88 | -0.75 | 0.46 | -9.08 | -3.03 | 0.003 |
Nephrosclerosis yes/no | -1.24 | -0.42 | 0.66 | 3.32 | 0.81 | 0.42 | -3.20 | -1.15 | 0.25 | -1.45 | -0.44 | 0.66 |