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Supportive Care in Cancer

Erschienen in:

19.09.2020 | Original Article

Health-related quality of life measured using EQ-5D in patients with lymphomas

verfasst von: Richard Huan Xu, Eliza Lai-yi Wong, Jun Jin, Huiqiang Huang, Dong Dong

Erschienen in: Supportive Care in Cancer | Ausgabe 5/2021

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Abstract

Purpose

This study aimed to estimate the health preference–based index scores of the population of patients with lymphoma using the EQ-5D in China.

Methods

A cross-sectional online survey was conducted to examine the health and well-being of patients with lymphoma in China. Their health-related quality of life (HRQoL; using the EQ-5D), demographic and socioeconomic characteristics, and health conditions were assessed. The data were analyzed using Pearson’s χ² test, analysis of variance, and binary logistic and Tobit regression models.

Results

A total of 3261 patients (sex: men = 58.5%, age: < 30 years = 9.5% and > 60 years = 24.6%) participated in the study. The mean EQ-5D-5L index and EQ-VAS scores were 0.83 and 68.8, respectively. Binary logistic regression analysis revealed that women reported more pain-related problems than men did. Unemployed participants were substantially more likely to report health problems on all the five dimensions of the EQ-5D than their employed counterparts. The Tobit regression model revealed that respondents who were older, unemployed, with low income, received chemotherapy, and with short durations reported a low index score.

Conclusion

Using the EQ-5D, the preference-based scores of different subpopulations of patients with lymphoma may support economic evaluation by promoting the simultaneous consideration of both the reasonable use of resources and satisfactory achievement of health outcomes.

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Center for disease control and prevention. Lymphoma. https://www.cdc.gov/cancer/lymphoma/index.htm

Lymphoma Action. What is lymphoma? https://lymphoma-action.org.uk/about-lymphoma/what-lymphoma

Cancer Council Australia. Lymphoma. http://www.cancer.org.au/about-cancer/types-of-cancer/lymphoma.html

Center for disease control and prevention. Leading Cancer Cases and Deaths. https://gis.cdc.gov/Cancer/USCS/DataViz.html

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J (2016) Cancer statistics in China, 2015. CA Cancer J Clin 66:115–132. https://doi.org/10.3322/caac.21338 CrossRef

Doolittle N, Korfel A, Lubow MA et al (2013) Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma. Neurology 81:84–92CrossRef

Brazier J, Yang Y, Tsuchiya A et al (2010) A review of studies mapping (or cross walking) non-preference based measures of health to generic preference-based measures. Heal Econ Prev Care 11:215–225. https://doi.org/10.1007/s10198-009-0168-z CrossRef

Herdman M, Gudex C, Lloyd A, Janssen MF, Kind P, Parkin D, Bonsel G, Badia X (2011) Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). An Int J Qual Life Asp Treat Care Rehabil 20:1727–1736. https://doi.org/10.1007/s11136-011-9903-x CrossRef

Sullivan PW, Ghushchyan VH (2016) EQ-5D scores for diabetes-related comorbidities. Value Heal 19:1002–1008. https://doi.org/10.1016/j.jval.2016.05.018 CrossRef

10.

Rencz F, Gulácsi L, Drummond M, Golicki D, Prevolnik Rupel V, Simon J, Stolk EA, Brodszky V, Baji P, Závada J, Petrova G, Rotar A, Péntek M (2016) EQ-5D in Central and Eastern Europe: 2000–2015. Qual Life Res 25:2693–2710. https://doi.org/10.1007/s11136-016-1375-6 CrossRefPubMed

11.

Rowen D, Azzabi Zouraq I, Chevrou-Severac H, van Hout B (2017) International regulations and recommendations for utility data for health technology assessment. Pharmacoeconomics 35:11–19. https://doi.org/10.1007/s40273-017-0544-y CrossRefPubMed

12.

Ramsey SD, Nademanee A, Masszi T, Holowiecki J, Abidi M, Chen A, Stiff P, Viviani S, Sweetenham JW, Radford J, Zhu Y, Bonthapally V, Thomas E, Richhariya A, Hunder NN, Walewski J, Moskowitz CH (2016) Quality of life results from a phase 3 study of brentuximab vedotin consolidation following autologous haematopoietic stem cell transplant for persons with Hodgkin lymphoma. Br J Haematol 175:860–867. https://doi.org/10.1111/bjh.14316 CrossRefPubMedPubMedCentral

13.

Glaser AW, Fraser LK, Corner J, Feltbower R, Morris EJ, Hartwell G, Richards M, Wagland R (2013) Patient-reported outcomes of cancer survivors in England 1–5 years after diagnosis: a cross-sectional survey. BMJ Open 3:e002317. https://doi.org/10.1136/bmjopen-2012-002317 CrossRefPubMedPubMedCentral

14.

Wang H, Smith A, Yu G, Aas E, Bagguley T, Howell D, Roman E, Burton C, Patmore R (2017) PCN203 - UK utility elicitation in patients with follicular lymphoma. Value Heal 20:A449–A449. https://doi.org/10.1016/j.jval.2017.08.286 CrossRef

15.

Jefford M, Ward A, Lisy K et al (2017) Patient-reported outcomes in cancer survivors: a population-wide cross-sectional study. Support Care Cancer 25:3171–3179. https://doi.org/10.1007/s00520-017-3725-5 CrossRefPubMed

16.

Davies A, Waylen A, Leary S, Thomas S, Pring M, Janssen B, Beynon R, Lang S, Schimansky S, Hurley K, Ness A (2020) Assessing the validity of EQ-5D-5L in people with head & neck cancer: does a generic quality of life measure perform as well as a disease-specific measure in a patient population? Oral Oncol 101:104504. https://doi.org/10.1016/j.oraloncology.2019.104504 CrossRefPubMed

17.

Cheung Y, Thumboo J (2006) Developing health-related quality-of-life instruments for use in Asia. Pharmacoeconomics 24:643–650. https://doi.org/10.2165/00019053-200624070-00003 CrossRefPubMed

18.

Sitlinger A, Zafar SY (2018) Health-related quality of life: the impact on morbidity and mortality. Surg Oncol Clin N Am 27:675–684. https://doi.org/10.1016/j.soc.2018.05.008 CrossRefPubMedPubMedCentral

19.

Luo N, Liu G, Li M, Guan H, Jin X, Rand-Hendriksen K (2017) Estimating an EQ-5D-5L value set for China. Value Heal 20:662–669. https://doi.org/10.1016/j.jval.2016.11.016 CrossRef

20.

Mair P, Wilcox R (2018;forthcoming) Robust statistical methods Using WRS2. J Stat Softw. https://doi.org/10.18637/jss.v000.i00

21.

Norum J, Angelsen V, Wist E, Olsen JA (1996) Treatment costs in Hodgkin’s disease: a cost-utility analysis. Eur J Cancer 32:1510–1517. https://doi.org/10.1016/0959-8049(96)00142-6 CrossRef

22.

Pickard AS, Jiang R, Lin H-W, Rosenbloom S, Cella D (2016) Using patient-reported outcomes to compare relative burden of cancer: EQ-5D and functional assessment of cancer therapy-general in eleven types of Cancer. Clin Ther 38:769–777. https://doi.org/10.1016/j.clinthera.2016.03.009 CrossRefPubMed

23.

Crott R, Versteegh M, Uyl-de-Groot C (2013) An assessment of the external validity of mapping QLQ-C30 to EQ-5D preferences. An Int J Qual Life Asp Treat Care Rehabil 22:1045–1054. https://doi.org/10.1007/s11136-012-0220-9 CrossRef

24.

Brandt J, Dietrich S, Meissner J, Neben K, Ho AD, Witzens-Harig M (2010) Quality of life of long-term survivors with Hodgkin lymphoma after high-dose chemotherapy, autologous stem cell transplantation, and conventional chemotherapy. Leuk Lymphoma 51:2012–2020. https://doi.org/10.3109/10428194.2010.513749 CrossRefPubMed

25.

Wong ELY, Xu RH, Cheung AWL (2019) Health-related quality of life among patients with hypertension: population-based survey using EQ-5D-5L in Hong Kong SAR, China. BMJ Open 9:e032544. https://doi.org/10.1136/bmjopen-2019-032544 CrossRefPubMedPubMedCentral

26.

Daniëls LA, Oerlemans S, Krol ADG, Creutzberg CL, van de Poll-Franse LV (2014) Chronic fatigue in Hodgkin lymphoma survivors and associations with anxiety, depression and comorbidity. Br J Cancer 110:868–874. https://doi.org/10.1038/bjc.2013.779 CrossRefPubMedPubMedCentral

27.

Oerlemans S, Mols F, Nijziel M et al (2014) The course of anxiety and depression for patients with Hodgkin’s lymphoma or diffuse large B cell lymphoma: a longitudinal study of the PROFILES registry. Res Pract 8:555–564. https://doi.org/10.1007/s11764-014-0367-1 CrossRef

28.

Baeza-Velasco C, Baguet F, Allart P, Aguerre C, Sultan S, Ninot G, Soubeyran P, Cousson-Gelie F (2017) Major depressive disorder and associated factors in elderly patients with non-Hodgkin’s lymphoma. Heal Psychol Behav Med 5:57–65. https://doi.org/10.1080/21642850.2016.1264879 CrossRef

29.

Casellas-Grau A, Ochoa C, Ruini C (2017) Psychological and clinical correlates of posttraumatic growth in cancer: a systematic and critical review. Psycho-Oncology 26:2007–2018. https://doi.org/10.1002/pon.4426 CrossRefPubMed

30.

Weiss Wiesel TR, Nelson CJ, Tew WP, Hardt M, Mohile SG, Owusu C, Klepin HD, Gross CP, Gajra A, Lichtman SM, Ramani R, Katheria V, Zavala L, Hurria A, On behalf of the Cancer Aging Research Group (CARG) (2015) The relationship between age, anxiety, and depression in older adults with cancer. Psycho-Oncology 24:712–717. https://doi.org/10.1002/pon.3638 CrossRefPubMed

31.

Kim SH, Lee S, Kim SH, Ok ON, Kim IR, Choi E, Kang YK, Kim SJ, Lee MH (2017) Unmet needs of non-Hodgkin lymphoma survivors in Korea: prevalence, correlates, and associations with health-related quality of life. Psycho-Oncology 26:330–336. https://doi.org/10.1002/pon.4136 CrossRefPubMed

32.

Holahan HM, Farah RS, Fitz S, Mott SL, Ferguson NN, McKillip J, Link B, Liu V (2018) Health-related quality of life in patients with cutaneous T-cell lymphoma? Int J Dermatol 57:1314–1319. https://doi.org/10.1111/ijd.14132 CrossRefPubMed

33.

Short Farley P, Mallonee L (2006) E. Income disparities in the quality of life of cancer survivors. Med Care 44:16–23CrossRef

34.

Marmot M (2002) The influence of income on health: views of an epidemiologist. Health Aff 21:31–46. https://doi.org/10.1377/hlthaff.21.2.31 CrossRef

35.

Loh DA, Moy FM, Zaharan NL, Mohamed Z (2015) Disparities in health-related quality of life among healthy adolescents in a developing country – the impact of gender, ethnicity, socio-economic status and weight status. Child Care Health Dev 41:1216–1226. https://doi.org/10.1111/cch.12252 CrossRefPubMed

36.

Vargo JA, Gill BS, Balasubramani GK, Beriwal S (2015) Treatment selection and survival outcomes in early-stage diffuse large B-cell lymphoma: do we still need consolidative radiotherapy? J Clin Oncol 33:3710–3717. https://doi.org/10.1200/JCO.2015.61.7654 CrossRefPubMed

37.

American cancer society. Radiation therapy for Hodgkin lymphoma. https://www.cancer.org/cancer/non-hodgkin-lymphoma/treating/radiation-therapy.html. Accessed 1 May 2020

38.

Castellino SM, Parsons SK, Kelly KM (2019) Closing the survivorship gap in children and adolescents with Hodgkin lymphoma. Br J Haematol 187:573–587. https://doi.org/10.1111/bjh.16197 CrossRefPubMed

Titel: Health-related quality of life measured using EQ-5D in patients with lymphomas
verfasst von: Richard Huan Xu
Eliza Lai-yi Wong
Jun Jin
Huiqiang Huang
Dong Dong
Publikationsdatum: 19.09.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 5/2021
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-020-05774-6

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Health-related quality of life measured using EQ-5D in patients with lymphomas

Abstract

Purpose

Methods

Results

Conclusion

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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