Introduction
Methods
Study Population and Data Source
Statistical Analysis
Compliance with Ethics Guidelines
Results
Characteristics | Acthar Rxa (≤30 days post-index) n = 191 (76%) | Acthar Rxa (>30 days post-index) n = 61 (24%) |
P valueb
|
---|---|---|---|
Age (years), mean (SD) | 0.62 (0.49) | 0.64 (0.48) | 0.76 |
Age 0 to < 1 year | 73 (38%) | 22 (36%) | 0.76 |
Age 1 to < 2 years | 118 (62%) | 39 (64%) | |
Female | 74 (39%) | 33 (54%) | 0.03 |
Male | 117 (61%) | 28 (46%) | |
Non-Medicaid | 154 (81%) | 49 (80%) | 0.96 |
Medicaid | 37 (19%) | 12 (20%) | |
Type of health plan | |||
Comprehensive | 18 (9%) | 9 (15%) | 0.42 |
Exclusive/preferred provider organization | 93 (49%) | 32 (52%) | |
Health maintenance organization | 46 (24%) | 9 (15%) | |
Point of service | 19 (10%) | 7 (11%) | |
Consumer-directed/high-deductible | 15 (8%) | 3 (5%) | |
Missing | 0 (0.0%) | 1 (1%) | |
Geographic region | |||
Northeast | 27 (14%) | 9 (15%) | 0.82 |
North Central | 46 (24%) | 13 (21%) | |
South | 51 (27%) | 16 (26%) | |
West | 25 (13%) | 11 (18%) | |
Missingc
| 42 (22%) | 12 (20%) | |
Year of IS incident | |||
2007 | 29 (15%) | 7 (11%) | 0.19 |
2008 | 35 (18%) | 21 (34%) | |
2009 | 34 (18%) | 8 (13%) | |
2010 | 35 (18%) | 11 (18%) | |
2011 | 30 (16%) | 8 (13%) | |
2012 | 28 (15%) | 6 (10%) | |
Rx filled prior to IS diagnosisd
| |||
Steroid | 11 (6%) | 6 (10%) | 0.27 |
Anticonvulsant | 41 (21%) | 20 (33%) | 0.07 |
Vigabatrin | 0 (0.0%) | 0 (0.0%) | – |
Comorbidities diagnosed prior to IS diagnosise
| |||
Major cardiac diseases | 43 (23%) | 19 (31%) | 0.17 |
Metabolic conditions | 17 (9%) | 6 (10%) | 0.83 |
Severe central nervous system malformations | 26 (14%) | 19 (31%) | 0.002 |
Number of utilizations from days −90 to −1, mean ± SD (range) | |||
Outpatient services | 10.2 ± 9.6 (0–54) | 12.5 ± 9.5 (1–38) | 0.12 |
Hospital admissions | 0.2 ± 0.5 (0–2) | 0.6 ± 1.0 (0–4) | 0.0002 |
Medications | 3.5 ± 4.9 (0–31) | 4.0 ± 4.4 (0–19) | 0.54 |
12-month outcome | Early Acthar Rx (≤30 days post-index), mean (median) ± SD | Late Acthar Rx (>30 days post-index), mean (median) ± SD | Difference in means (99% CI) |
P value |
---|---|---|---|---|
Number of hospitalizations | 2.2 (2.0) ± 1.9 | 2.4 (2.0) ± 2.0 | −0.2 (−0.9, 0.6) | 0.55 |
Mean length of stay (days)a
| 4.2 (3.0) ± 4.3 | 4.3 (3.0) ± 4.9 | −0.1 (−1.9, 1.7) | 0.88 |
Number of ICU admissionsa
| 0.3 (0) ± 0.7 | 0.5 (0) ± 1.5 | −0.2 (−0.6, 0.2) | 0.26 |
Number of ER visits | 1.0 (0) ± 1.7 | 1.1 (1.0) ± 1.5 | −0.1 (−0.7, 0.6) | 0.83 |
Number of IS-related ER visitsa
| 0.2 (0) ± 0.5 | 0.2 (0) ± 0.5 | 0 (−0.3, 0.3) | 0.95 |
Number of outpatient services | 62 (49) ± 43 | 74 (65) ± 42 | −12 (−29, 3.7) | 0.05 |
Number of Rx medication fills | 30.5 (27) ± 22 | 35.9 (26) ± 23 | −5.4 (−14, 3.2) | 0.10 |
Number of all health services combined | 94 (82) ± 57 | 112 (110) ± 58 | −18 (−40, 3.9) | 0.03 |
Total hospitalization costs ($) | 72,100 (21,000) ± 170,000 | 76,300 (17,100) ± 152,000 | −4200 (−68,000, 59,000) | 0.86 |
Total outpatient costs ($) | 38,100 (17,200) ± 58,300 | 44,700 (21,900) ± 69,900 | −6600 (−30,000, 17,000) | 0.46 |
Total medication costs ($) | 93,100 (84,300) ± 81,300 | 88,300 (79,800) ± 76,400 | 4800 (−26,000, 35,000) | 0.68 |
Total cost of services ($) | 203,300 (149,000) ± 204,000 | 209,300 (146,000) ± 199,000 | −6000 (−83,000, 71,000) | 0.84 |
12-month outcome | Frequency (%) among patients receiving early Acthar Rx* (≤30 days post-index) | Frequency (%) among patients receiving late Acthar Rx* (>30 days post-index) | Odds ratio (99% CI) |
P value |
---|---|---|---|---|
Readmissions within 30 days (yes/no)a
| 59 (31%) | 14 (23%) | 1.5 (0.6, 3.6) | 0.24 |
Adjusted mean (99% CI) for patients receiving Acthar Rx earlya
| Adjusted mean (99% CI) for patients receiving Acthar Rx latea
| Adjusted difference in means (99% CI)a
|
P value | |
---|---|---|---|---|
Number of hospitalizations | 2.3 (2.0, 2.6) | 2.2 (1.7, 2.7) | 0.1 (−0.4, 0.8) | 0.77 |
Mean length of stay (days)b
| 4.2 (3.8, 4.6) | 4.2 (3.6, 5.1) | 0 (−0.8, 1.0) | 0.88 |
Number of ICU admissionsb
| 0.3 (0.2, 0.4) | 0.3 (0.2, 0.6) | 0 (−0.1, 0.4) | 0.90 |
Number of ER visits | 1.0 (0.9, 1.3) | 0.9 (0.6, 1.2) | 0.1 (−0.1, 0.7) | 0.24 |
Number of IS-related ER visitsb
| 0.2 (0.1, 0.4) | 0.2 (0.1, 0.5) | 0 (−0.1, 0.8) | 0.53 |
Number of outpatient services | 62 (60, 63) | 65 (63, 68) | −3.8 (−6.7, −0.7) | 0.002 |
Number of prescription medication fills | 31 (30, 32) | 31 (29, 33) | −0.4 (−2.5, 1.8) | 0.60 |
Number of all health services combined | 95 (93, 97) | 99 (96, 102) | −4.2 (−7.9, −0.4) | 0.005 |
Total hospitalization costs ($)c
| 69,800 (50,000, 98,000) | 79,500 (41,000, 155,000) | −9700 (−69,000, 50,000) | 0.67 |
Total outpatient costs ($)c
| 37,900 (31,000, 46,000) | 39,000 (27,000, 57,000) | −1100 (−18,000, 16,000) | 0.87 |
Total medication costs ($)c
| 93,100 (70,000, 124,000) | 87,200 (51,000, 148,000) | 5900 (−50,000, 62,000) | 0.79 |
Total cost of services ($) | 203,000 (173,000, 238,000) | 201,900 (150,000, 272,000) | 1100 (−70,000, 72,000) | 0.97 |
Adjusted mean (99% CI) for patients receiving Acthar earlya
| Adjusted mean (99% CI) for patients receiving Acthar latea
| Adjusted odds ratio (99% CI)a
|
P value | |
---|---|---|---|---|
Readmissions within 30 days (yes/no)b
| 0.4 (0.3, 0.4) | 0.2 (0.1, 0.4) | 1.9 (0.7, 5.0) | 0.09 |