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11.01.2019 | Original Article

Heart rate recovery after maximal exercise is impaired in healthy young adults born preterm

verfasst von: Kristin Haraldsdottir, Andrew M. Watson, Arij G. Beshish, Dave F. Pegelow, Mari Palta, Laura H. Tetri, Melissa D. Brix, Ryan M. Centanni, Kara N. Goss, Marlowe W. Eldridge

Erschienen in: European Journal of Applied Physiology | Ausgabe 4/2019

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Abstract

Purpose

The long-term implications of premature birth on autonomic nervous system (ANS) function are unclear. Heart rate recovery (HRR) following maximal exercise is a simple tool to evaluate ANS function and is a strong predictor of cardiovascular disease. Our objective was to determine whether HRR is impaired in young adults born preterm (PYA).

Methods

Individuals born between 1989 and 1991 were recruited from the Newborn Lung Project, a prospectively followed cohort of subjects born preterm weighing < 1500 g with an average gestational age of 28 weeks. Age-matched term-born controls were recruited from the local population. HRR was measured for 2 min following maximal exercise testing on an upright cycle ergometer in normoxia and hypoxia, and maximal aerobic capacity (VO_2max) was measured.

Results

Preterms had lower VO_2max than controls (34.88 ± 5.24 v 46.15 ± 10.21 ml/kg/min, respectively, p < 0.05), and exhibited slower HRR compared to controls after 1 and 2 min of recovery in normoxia (absolute drop of 20 ± 4 v 31 ± 10 and 41 ± 7 v 54 ± 11 beats per minute (bpm), respectively, p < 0.01) and hypoxia (19 ± 5 v 26 ± 8 and 39 ± 7 v 49 ± 13 bpm, respectively, p < 0.05). After adjusting for VO_2max, HRR remained slower in preterms at 1 and 2 min of recovery in normoxia (21 ± 2 v 30 ± 2 and 42 ± 3 v 52 ± 3 bpm, respectively, p < 0.05), but not hypoxia (19 ± 3 v 25 ± 2 and 40 ± 4 v 47 ± 3 bpm, respectively, p > 0.05).

Conclusions

Autonomic dysfunction as seen in this study has been associated with increased rates of cardiovascular disease in non-preterm populations, suggesting further study of the mechanisms of autonomic dysfunction after preterm birth.

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Titel: Heart rate recovery after maximal exercise is impaired in healthy young adults born preterm
verfasst von: Kristin Haraldsdottir
Andrew M. Watson
Arij G. Beshish
Dave F. Pegelow
Mari Palta
Laura H. Tetri
Melissa D. Brix
Ryan M. Centanni
Kara N. Goss
Marlowe W. Eldridge
Publikationsdatum: 11.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 4/2019
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04075-z

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