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Clinical Autonomic Research
Erschienen in: Clinical Autonomic Research 3/2019

13.04.2018 | Research Article

Heart rate variability and baroreflex sensitivity abnormalities in Guillain–Barré syndrome: a pilot study

verfasst von: Cheng-Yin Tan, Nortina Shahrizaila, Kee-Ying Yeoh, Khean-Jin Goh, Maw-Pin Tan

Erschienen in: Clinical Autonomic Research | Ausgabe 3/2019

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Abstract

Objective

The current study aimed to investigate autonomic dysfunction in Guillain–Barré syndrome (GBS) patients and describe the results of computational heart rate variability (HRV)/baroreflex sensitivity (BRS) and autonomic challenge tests.

Methods

GBS patients were consecutively recruited and the results were compared to age- and gender-matched healthy controls. A series of autonomic function tests including computation-dependent tests (power spectrum analysis of HRV and BRS at rest) and challenge maneuvers (deep breathing, eyeball compression, active standing, the Valsalva maneuver, sustained handgrip, and the cold pressor test) were performed.

Results

Ten GBS patients (six men; mean age = 40.1 ± 13.9 years) and ten gender- and age-matched healthy controls were recruited. The mean GBS functional grading scale at disease plateau was 3.4 ± 1.0. No patients required intensive care unit admission or mechanical ventilation. Low-frequency HRV (p = 0.027), high-frequency HRV (p = 0.008), and the total power spectral density of HRV (p = 0.015) were significantly reduced in patients compared to controls. The mean up slope (p = 0.034), down slope (p = 0.011), and total slope (p = 0.024) BRS were significantly lower in GBS patients. The diastolic rise in blood pressure in the cold pressor test was significantly lower in GBS patients compared to controls (p = 0.008).

Interpretation

Computation-dependent tests (HRV and BRS) were more useful for detecting autonomic dysfunction in GBS patients, whereas the cold pressor test was the only reliable challenge test, making it useful as a bedside measure of autonomic function in GBS patients.
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Metadaten
Titel
Heart rate variability and baroreflex sensitivity abnormalities in Guillain–Barré syndrome: a pilot study
verfasst von
Cheng-Yin Tan
Nortina Shahrizaila
Kee-Ying Yeoh
Khean-Jin Goh
Maw-Pin Tan
Publikationsdatum
13.04.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 3/2019
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-018-0525-z

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