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Seminars in Immunopathology

Erschienen in:

01.03.2013 | Review

Helicobacter pylori infection and gastric carcinogenesis in rodent models

verfasst von: Tetsuya Tsukamoto, Takeshi Toyoda, Tsutomu Mizoshita, Masae Tatematsu

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2013

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Abstract

Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.

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Titel: Helicobacter pylori infection and gastric carcinogenesis in rodent models
verfasst von: Tetsuya Tsukamoto
Takeshi Toyoda
Tsutomu Mizoshita
Masae Tatematsu
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 2/2013
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-012-0357-1

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