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Current Osteoporosis Reports

Erschienen in:

01.06.2011

Hematopoietic Cell Regulation of Osteoblast Proliferation and Differentiation

verfasst von: Monique Bethel, Edward F. Srour, Melissa A. Kacena

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2011

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Abstract

The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lineage. For example, OBs are important players in the hematopoietic stem cell (HSC) niche and OBs are known to impact osteoclast (OC) development. Thus, although much is known regarding the impact OBs have on hematopoietic cells, less is known about the impact of hematopoietic cells on OBs. Here we will review this reciprocal relationship: the effects of hematopoietic cells on OBs. Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell–derived OCs on OB proliferation, differentiation, and function.

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Titel: Hematopoietic Cell Regulation of Osteoblast Proliferation and Differentiation
verfasst von: Monique Bethel
Edward F. Srour
Melissa A. Kacena
Publikationsdatum: 01.06.2011
Verlag: Current Science Inc.
Erschienen in: Current Osteoporosis Reports / Ausgabe 2/2011
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-011-0048-1

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