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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 2/2011

01.06.2011

Role of Endocrine and Paracrine Factors in the Adaptation of Bone to Mechanical Loading

verfasst von: Joanna S. Price, Toshihiro Sugiyama, Gabriel L. Galea, Lee B. Meakin, Andrew Sunters, Lance E. Lanyon

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2011

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Abstract

There appears to be no unique mechanically sensitive pathway by which changes in bone loading regulate bone mass and architecture to ensure adequate structural strength. Rather, strain-derived changes in bone cells activate a number of nonspecific strain-sensitive pathways (including calcium fluxes, prostanoids, nitric oxide, extracellular signal-regulated kinase, and sclerostin), the activities of which are modified by a number of factors (including estrogen receptors) for which this contribution is subsidiary to other purposes. The strain-sensitive pathways modified by these factors interact with a number of other pathways, some of which appear to have specific osteoregulatory potential (eg, the parathyroid hormone pathway), whereas others such as the Wnt pathway appear to be associated primarily with the response mechanisms of proliferation, differentiation, and apoptosis. The outcome of these multiple interactions are stimuli for local bone formation, resorption, or maintenance of the status quo, to maintain existing bone architecture or adapt it to a new mechanical regimen.
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Metadaten
Titel
Role of Endocrine and Paracrine Factors in the Adaptation of Bone to Mechanical Loading
verfasst von
Joanna S. Price
Toshihiro Sugiyama
Gabriel L. Galea
Lee B. Meakin
Andrew Sunters
Lance E. Lanyon
Publikationsdatum
01.06.2011
Verlag
Current Science Inc.
Erschienen in
Current Osteoporosis Reports / Ausgabe 2/2011
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-011-0050-7

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