Erschienen in:
01.03.2015 | EDITORIAL COMMENTARY
Hepatitis B and C Infections in Multitransfused Thalassemic Patients
verfasst von:
Ved Prakash Choudhry
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 3/2015
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Excerpt
Transfusion transmitted infections (TTI) are major causes of morbidity and mortality among multi-transfused patients such as thalassemics, hemophilics, patients on hemodialysis
etc. Article by Sabat et al. in this issue of the Journal is of great concern for developing countries, including India where the prevalence of antibodies to hepatitis C, HBsAg, anti HBs and anti HBc was observed in 3.4, 0.5, 30.4 and 21.8% of 174 thalassemic cases respectively [
1]. Higher prevalence with increasing age and blood transfusion is well understood. However, the major concern is of occult hepatitis B infection (OHBV) in 50% cases with positive anti HBc. Higher incidence of OHBV has been reported earlier [
2,
3]. Presence of OHBV in patients with liver cirrhosis is still higher [
4,
5]. Presence of HBV DNA in over 16% anti HBs and anti HBc positive patients is indicative of continued viral replication, which may consequently lead to development of liver cirrhosis or hepatocellular carcinoma [
1]. …
