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Neurological Sciences

Erschienen in:

22.08.2019 | Original Article

High HbA_1c level is correlated with blood-brain barrier disruption in syphilis patients

verfasst von: Feng Wang, Hua Ge, Xinhui Su, Ru Wang, Jianqi Zeng, Jiayin Miao

Erschienen in: Neurological Sciences | Ausgabe 1/2020

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Abstract

Diabetes mellitus (DM) and neurosyphilis (NS) may both damage the blood-brain barrier (BBB). It seems that non-neurosyphilis (non-NS) patients with high HbA_1c levels are likely to develop into NS. However, the correlation of HbA_1c level with BBB disruption in syphilis (non-NS) patients is unclear. In this study, we used dynamic contrast-enhanced (DCE) MRI to quantify regional BBB permeability in syphilis (non-NS) patients and detected several molecular biomarkers of cerebrospinal fluid (CSF). We found that BBB permeability values in the hippocampus, white matter, and cortex inferior temporal gyrus were correlated with albumin quotient (Qalb), CSF concentrations of interleukin IL-6 and IL-10. Moreover, BBB breakdown in white matter was correlated with CSF concentrations of sICAM-1 and sVCAM-1. In conclusion, our data suggest that BBB integrity may be liable to be disrupted in syphilis (non-NS) patients, patients with high HbA_1c levels, as well as syphilis (non-NS) patients with high HbA_1c levels, and it is particularly important to control blood glucose in these patients.

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Titel: High HbA1c level is correlated with blood-brain barrier disruption in syphilis patients
verfasst von: Feng Wang
Hua Ge
Xinhui Su
Ru Wang
Jianqi Zeng
Jiayin Miao
Publikationsdatum: 22.08.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 1/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04031-x

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