Skip to main content
Erschienen in: European Journal of Applied Physiology 3/2017

03.02.2017 | Original Article

High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes

verfasst von: Eva Maria Støa, Sondre Meling, Lill-Katrin Nyhus, Glenn Strømstad, Karl Magnus Mangerud, Jan Helgerud, Solfrid Bratland-Sanda, Øyvind Støren

Erschienen in: European Journal of Applied Physiology | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

It remains to be established how high-intensity aerobic interval training (HAIT) affects risk factors associated with type 2 diabetes (TD2). This study investigated effects of HAIT on maximal oxygen uptake (VO2max), glycated Hemoglobin type A1C (HbA1c), insulin resistance (IR), fat oxidation (FatOx), body weight (BW), percent body fat (%BF), lactate threshold (LT), blood pressure (BP), and blood lipid profile (BLP) among persons with T2D. Results were compared to the effects after a moderate-intensity training (MIT) program.

Methods

Thirty-eight individuals with T2D completed 12 weeks of supervised training. HAIT consisted of 4 × 4 min of walking or running uphill at 85–95% of maximal heart rate, and MIT consisted of continuous walking at 70–75% of maximal heart rate.

Results

A 21% increase in VO2max (from 25.6 to 30.9 ml kg−1 min−1, p < 0.001), and a reduction in HbA1c by −0.58% points (from 7.78 to 7.20%, p < 0.001) was found in HAIT. BW and body mass index (BMI) was reduced by 1.9% (p < 0.01). There was a tendency towards an improved FatOx at 60% VO2max (14%, p = 0.065). These improvements were significant different from MIT. Both HAIT and MIT increased velocity at LT, and reduced %BF, waist circumference, hip circumference, and BP, with no significant differences between the two groups. Correlations were found between change in VO2max and change in HbA1c when the two intervention groups were combined (R = −0.52, p < 0.01).

Conclusion

HAIT is an effective exercise strategy to improve aerobic fitness and reduce risk factors associated with T2D.
Literatur
Zurück zum Zitat Achten J, Jeukendrup AE (2004) Optimizing fat oxidation through exercise and diet. Nutrition 20(7–8):716–727PubMed Achten J, Jeukendrup AE (2004) Optimizing fat oxidation through exercise and diet. Nutrition 20(7–8):716–727PubMed
Zurück zum Zitat American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33(1 Suppl):S62–S69PubMedCentral American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33(1 Suppl):S62–S69PubMedCentral
Zurück zum Zitat American Diabetes Association (2016) Standards of medical care in diabetes-2016. J Clin Appl Res Educ Diabetes Care 39(Suppl 1):S60–S80 American Diabetes Association (2016) Standards of medical care in diabetes-2016. J Clin Appl Res Educ Diabetes Care 39(Suppl 1):S60–S80
Zurück zum Zitat Bertoli A, Di Daniele N, Ceccobelli M, Ficara A, Girasoli C, De Lorenzo A (2003) Lipid profile, BMI, body fat distribution, and aerobic fitness in men with metabolic syndrome. Acta Diabetol 40(Suppl 1):S130–S133PubMed Bertoli A, Di Daniele N, Ceccobelli M, Ficara A, Girasoli C, De Lorenzo A (2003) Lipid profile, BMI, body fat distribution, and aerobic fitness in men with metabolic syndrome. Acta Diabetol 40(Suppl 1):S130–S133PubMed
Zurück zum Zitat Bordenave S, Flavier S, Fédou C, Brun JF, Mercier J (2007) Exercise calorimetry in sedentary patients: procedures based on short 3 min steps underestimate carbohydrate oxidation and overestimate lipid oxidation. Diabetes Metab 33(5):379–384PubMed Bordenave S, Flavier S, Fédou C, Brun JF, Mercier J (2007) Exercise calorimetry in sedentary patients: procedures based on short 3 min steps underestimate carbohydrate oxidation and overestimate lipid oxidation. Diabetes Metab 33(5):379–384PubMed
Zurück zum Zitat Boulé NG, Kenny GP, Haddad E, Wells GA, Sigal RJ (2003) Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in type 2 diabetes mellitus. Diabetologia 46:1071–1081PubMed Boulé NG, Kenny GP, Haddad E, Wells GA, Sigal RJ (2003) Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in type 2 diabetes mellitus. Diabetologia 46:1071–1081PubMed
Zurück zum Zitat Carroll S, Dudfield M (2004) What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sports Med 34(6):371–418PubMed Carroll S, Dudfield M (2004) What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sports Med 34(6):371–418PubMed
Zurück zum Zitat Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, Chasan-Taber L, Albright AL, Braun B (2010) Exercise and type 2 Diabetes. The American College of Sports medicine and the American Diabetes Association: joint position stand. Diabetes Care 33(12):147–167 Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, Chasan-Taber L, Albright AL, Braun B (2010) Exercise and type 2 Diabetes. The American College of Sports medicine and the American Diabetes Association: joint position stand. Diabetes Care 33(12):147–167
Zurück zum Zitat DiPietro L, Dziura J, Yeckel CW, Neufer PD (2006) Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 100:142–149PubMed DiPietro L, Dziura J, Yeckel CW, Neufer PD (2006) Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 100:142–149PubMed
Zurück zum Zitat Dobrosielski DA, Gibbs BB, Ouyang P, Bonekamp S, Clark JM, Wang NY, Silber HA, Shapiro EP, Stewart KJ (2010) Effect of exercise on blood pressure in type 2 diabetes: a randomized controlled trial. J Gen Intern Med 27(11):1453–1459. doi:10.1007/s11606-012-2103-8 CrossRef Dobrosielski DA, Gibbs BB, Ouyang P, Bonekamp S, Clark JM, Wang NY, Silber HA, Shapiro EP, Stewart KJ (2010) Effect of exercise on blood pressure in type 2 diabetes: a randomized controlled trial. J Gen Intern Med 27(11):1453–1459. doi:10.​1007/​s11606-012-2103-8 CrossRef
Zurück zum Zitat Fletcher B, Gulanick M, Lamendola C (2002) Risk factors for type 2 diabetes mellitus. J Cardiovasc Nurs 16(2):17–23PubMed Fletcher B, Gulanick M, Lamendola C (2002) Risk factors for type 2 diabetes mellitus. J Cardiovasc Nurs 16(2):17–23PubMed
Zurück zum Zitat Frayn KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol Respir Environ Exerc Physiol 55(2):628–634PubMed Frayn KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol Respir Environ Exerc Physiol 55(2):628–634PubMed
Zurück zum Zitat Giannopoulou I, Ploutz-Snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S, Kanaley JA (2005) Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab 90(3):1511–1518 (Epub 14 Dec 2004) PubMed Giannopoulou I, Ploutz-Snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S, Kanaley JA (2005) Exercise is required for visceral fat loss in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab 90(3):1511–1518 (Epub 14 Dec 2004) PubMed
Zurück zum Zitat Hansen D, Dendale P, Jonkers RA, Beelen M, Manders RJ, Corluy L, Mullens A, Berger J, Meeusen R, van Loon LJ (2009) Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia 52:1789–1797PubMedPubMedCentral Hansen D, Dendale P, Jonkers RA, Beelen M, Manders RJ, Corluy L, Mullens A, Berger J, Meeusen R, van Loon LJ (2009) Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia 52:1789–1797PubMedPubMedCentral
Zurück zum Zitat Hawley JA, Zierath JR (2008) Physical activity and type 2 diabetes. Human Kinet Hawley JA, Zierath JR (2008) Physical activity and type 2 diabetes. Human Kinet
Zurück zum Zitat Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J (2007) Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc 39(4):665–671PubMed Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J (2007) Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc 39(4):665–671PubMed
Zurück zum Zitat Helgerud J, Støren O, Hoff J (2010) Are there differences in running economy at different velocities for well-trained distance runners? Eur J Appl Physiol 108(6):1099–1105PubMed Helgerud J, Støren O, Hoff J (2010) Are there differences in running economy at different velocities for well-trained distance runners? Eur J Appl Physiol 108(6):1099–1105PubMed
Zurück zum Zitat Helgerud J, Karlsen T, Kim WY, Høydal KL, Støylen A, Pedersen H, Brix L, Ringgaard S, Kværness J, Hoff J (2011) Interval and strength training in CAD patients. Int J Sports Med 32(1):54–59. doi:10.1055/s-0030-1267180 CrossRefPubMed Helgerud J, Karlsen T, Kim WY, Høydal KL, Støylen A, Pedersen H, Brix L, Ringgaard S, Kværness J, Hoff J (2011) Interval and strength training in CAD patients. Int J Sports Med 32(1):54–59. doi:10.​1055/​s-0030-1267180 CrossRefPubMed
Zurück zum Zitat Hollekim-Strand SM, Bjørgaas MR, Albrektsen G, Tjønna AE, Wisløff U, Ingul CB (2014) High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial. J Am Coll Cardiol 64(16):1758–1760. doi:10.1016/j.jacc.2014.07.971 CrossRefPubMed Hollekim-Strand SM, Bjørgaas MR, Albrektsen G, Tjønna AE, Wisløff U, Ingul CB (2014) High-intensity interval exercise effectively improves cardiac function in patients with type 2 diabetes mellitus and diastolic dysfunction: a randomized controlled trial. J Am Coll Cardiol 64(16):1758–1760. doi:10.​1016/​j.​jacc.​2014.​07.​971 CrossRefPubMed
Zurück zum Zitat Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR, American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD) (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35(6):1364–1379. doi:10.2337/dc12-0413 (Epub 19 Apr 2012) CrossRefPubMedPubMedCentral Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR, American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD) (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35(6):1364–1379. doi:10.​2337/​dc12-0413 (Epub 19 Apr 2012) CrossRefPubMedPubMedCentral
Zurück zum Zitat Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohashi Y, Yamada N, Sone H (2007) Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med 167(10):999–1008PubMed Kodama S, Tanaka S, Saito K, Shu M, Sone Y, Onitake F, Suzuki E, Shimano H, Yamamoto S, Kondo K, Ohashi Y, Yamada N, Sone H (2007) Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med 167(10):999–1008PubMed
Zurück zum Zitat Krook A, Holm I, Pettersson S, Wallberg-Henriksson H (2003) Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insulin dependent) diabetes mellitus. Clin Physiol Funct Imaging 23(1):21–30PubMed Krook A, Holm I, Pettersson S, Wallberg-Henriksson H (2003) Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insulin dependent) diabetes mellitus. Clin Physiol Funct Imaging 23(1):21–30PubMed
Zurück zum Zitat Kunitomi M, Takahashi K, Wada J, Suzuki H, Miyatake N, Ogawa S, Ohta S, Sugimoto H, Shikata K, Makino H (2000) Re-evaluation of exercise prescription for Japanese type 2 diabetic patients by ventilatory threshold. Diabetes Res Clin Pract 50: 109–115 Kunitomi M, Takahashi K, Wada J, Suzuki H, Miyatake N, Ogawa S, Ohta S, Sugimoto H, Shikata K, Makino H (2000) Re-evaluation of exercise prescription for Japanese type 2 diabetic patients by ventilatory threshold. Diabetes Res Clin Pract 50: 109–115
Zurück zum Zitat Maron DJ (2000) The epidemiology of low levels of high-density lipoprotein cholesterol in patients with and without coronary artery disease. Am J Cardiol 86(12):14 Maron DJ (2000) The epidemiology of low levels of high-density lipoprotein cholesterol in patients with and without coronary artery disease. Am J Cardiol 86(12):14
Zurück zum Zitat Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419PubMed Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419PubMed
Zurück zum Zitat McArdle WD, Katch FI, Katch VL (2010) Exercise physiology. Lippingott Williams & Wilkins, Philadelphia McArdle WD, Katch FI, Katch VL (2010) Exercise physiology. Lippingott Williams & Wilkins, Philadelphia
Zurück zum Zitat McMurray RG, Ainsworth BE, Harrell JS, Griggs TR, Williams OD (1998) Is physical activity or aerobic power more influential on reducing cardiovascular disease risk factors? Med Sci Sports Exerc 30(10):1521–1529PubMed McMurray RG, Ainsworth BE, Harrell JS, Griggs TR, Williams OD (1998) Is physical activity or aerobic power more influential on reducing cardiovascular disease risk factors? Med Sci Sports Exerc 30(10):1521–1529PubMed
Zurück zum Zitat Nordby P, Saltin B, Helge JW (2006) Whole-body fat oxidation determined by graded exercise and indirect calorimetry: a role for muscle oxidative capacity? Scand J Med Sci Sports 16(3):209–214PubMed Nordby P, Saltin B, Helge JW (2006) Whole-body fat oxidation determined by graded exercise and indirect calorimetry: a role for muscle oxidative capacity? Scand J Med Sci Sports 16(3):209–214PubMed
Zurück zum Zitat Okita K, Iwahashi H, Kozawa J, Okauchi Y, Funahashi T, Imagawa A, Shimomura I (2013) Homeostasis model assessment of insulin resistance for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy. Endocr J 60(3):283–290PubMed Okita K, Iwahashi H, Kozawa J, Okauchi Y, Funahashi T, Imagawa A, Shimomura I (2013) Homeostasis model assessment of insulin resistance for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy. Endocr J 60(3):283–290PubMed
Zurück zum Zitat Østerås H, Hoff J, Helgerud J (2005) Effects of high-intensity endurance training on maximal oxygen consumption in healthy elderly people. J Appl Gerontol 24:377–387 Østerås H, Hoff J, Helgerud J (2005) Effects of high-intensity endurance training on maximal oxygen consumption in healthy elderly people. J Appl Gerontol 24:377–387
Zurück zum Zitat Pedersen BK, Saltin B (2006) Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 16(Suppl 1):3–63PubMed Pedersen BK, Saltin B (2006) Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports 16(Suppl 1):3–63PubMed
Zurück zum Zitat Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA (2004) American College of Sports Medicine position stand. Exercise and hypertension. American College of Sports Medicine. Med Sci Sports Exerc 36(3):533–553PubMed Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA (2004) American College of Sports Medicine position stand. Exercise and hypertension. American College of Sports Medicine. Med Sci Sports Exerc 36(3):533–553PubMed
Zurück zum Zitat Racette SB, Evans EM, Weiss EP, Hagberg JM, Holloszy JO (2006) Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50–95 year olds. Diabetes Care 29(3):673–678PubMed Racette SB, Evans EM, Weiss EP, Hagberg JM, Holloszy JO (2006) Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50–95 year olds. Diabetes Care 29(3):673–678PubMed
Zurück zum Zitat Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR (1995) Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc 27:875–881PubMed Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR (1995) Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc 27:875–881PubMed
Zurück zum Zitat Revdal A, Hollekim-Strand SM, Ingul CB (2016) Can time efficient exercise improve cardiometabolic risk factors in type 2 diabetes? A pilot study. J Sports Sci Med 15(2):308–313PubMedPubMedCentral Revdal A, Hollekim-Strand SM, Ingul CB (2016) Can time efficient exercise improve cardiometabolic risk factors in type 2 diabetes? A pilot study. J Sports Sci Med 15(2):308–313PubMedPubMedCentral
Zurück zum Zitat Rognmo Ø, Hetland E, Helgerud J, Hoff J, Slørdahl SA (2004) High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 11(3):216–222PubMed Rognmo Ø, Hetland E, Helgerud J, Hoff J, Slørdahl SA (2004) High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 11(3):216–222PubMed
Zurück zum Zitat Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265(3 Pt 1):E380–E391PubMed Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265(3 Pt 1):E380–E391PubMed
Zurück zum Zitat Sahlin K, Sallstedt EK, Bishop D, Tonkonogi M (2008) Turning down lipid oxidation during heavy exercise: what is the mechanism? J Physiol Pharmacol 59(Suppl 7):19–30PubMed Sahlin K, Sallstedt EK, Bishop D, Tonkonogi M (2008) Turning down lipid oxidation during heavy exercise: what is the mechanism? J Physiol Pharmacol 59(Suppl 7):19–30PubMed
Zurück zum Zitat Saydah SH, Fradkin J, Cowie CC (2004) Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291(3):335–342PubMed Saydah SH, Fradkin J, Cowie CC (2004) Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 291(3):335–342PubMed
Zurück zum Zitat Segerstrøm ÅB, Glans F, Eriksson KF, Holmbäck AM, Groop L, Thorsson O, Wollmer P (2010) Impact of exercise intensity and duration on insulin sensitivity in women with T2D. Eur J Int Med 21:404–408 Segerstrøm ÅB, Glans F, Eriksson KF, Holmbäck AM, Groop L, Thorsson O, Wollmer P (2010) Impact of exercise intensity and duration on insulin sensitivity in women with T2D. Eur J Int Med 21:404–408
Zurück zum Zitat Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, Golden SH (2004) Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 141(6):421–431PubMed Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, Golden SH (2004) Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 141(6):421–431PubMed
Zurück zum Zitat Solomon TP, Malin SK, Karstoft K, Knudsen SH, Haus JM, Laye MJ, Kirwan JP (2015) Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum. Diabetes Care 38(5):921–929. doi:10.2337/dc14-2813 CrossRefPubMedPubMedCentral Solomon TP, Malin SK, Karstoft K, Knudsen SH, Haus JM, Laye MJ, Kirwan JP (2015) Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum. Diabetes Care 38(5):921–929. doi:10.​2337/​dc14-2813 CrossRefPubMedPubMedCentral
Zurück zum Zitat Støa EM, Nyhus LK, Børresen SC, Nygaard C, Hovet ÅM, Bratland-Sanda S, Helgerud J, Støren Ø (2016) Day to day variability in fat oxidation and the effect after only 1 day of change in diet composition. Appl Physiol Nutr Metab 41(4):397–404. doi:10.1139/apnm-2015-0334 (Epub 8 Dec 2015) CrossRefPubMed Støa EM, Nyhus LK, Børresen SC, Nygaard C, Hovet ÅM, Bratland-Sanda S, Helgerud J, Støren Ø (2016) Day to day variability in fat oxidation and the effect after only 1 day of change in diet composition. Appl Physiol Nutr Metab 41(4):397–404. doi:10.​1139/​apnm-2015-0334 (Epub 8 Dec 2015) CrossRefPubMed
Zurück zum Zitat Støren O, Helgerud J, Støa EM, Hoff J (2008) Maximal strength training improves running economy in distance runners. Med Sci Sports Exerc 40(6):1087–1092PubMed Støren O, Helgerud J, Støa EM, Hoff J (2008) Maximal strength training improves running economy in distance runners. Med Sci Sports Exerc 40(6):1087–1092PubMed
Zurück zum Zitat Støren Ø, Helgerud J, Sæbø M, Støa EM, Bratland-Sanda S, Unhjem RJ, Hoff J, Wang E (2016) The impact of age on the VO2max response to high-intensity interval training. Med Sci Sports Exerc (Epub ahead of print) Støren Ø, Helgerud J, Sæbø M, Støa EM, Bratland-Sanda S, Unhjem RJ, Hoff J, Wang E (2016) The impact of age on the VO2max response to high-intensity interval training. Med Sci Sports Exerc (Epub ahead of print)
Zurück zum Zitat Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321(7258):405–412PubMedPubMedCentral Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321(7258):405–412PubMedPubMedCentral
Zurück zum Zitat Stutts WC (2002) Physical activity determinants in adults. Perceived benefits, barriers, and self efficacy. AAOHN J 50(11):499–507PubMed Stutts WC (2002) Physical activity determinants in adults. Perceived benefits, barriers, and self efficacy. AAOHN J 50(11):499–507PubMed
Zurück zum Zitat Sunde A, Støren O, Bjerkaas M, Larsen MH, Hoff J, Helgerud J (2010) Maximal strength training improves cycling economy in competitive cyclists. J Strength Cond Res 24(8):2157–2165PubMed Sunde A, Støren O, Bjerkaas M, Larsen MH, Hoff J, Helgerud J (2010) Maximal strength training improves cycling economy in competitive cyclists. J Strength Cond Res 24(8):2157–2165PubMed
Zurück zum Zitat Swain DP, Abernathy KS, Smith CS, Lee SJ, Bunn SA (1994) Target heart rates for the development of cardiorespiratory fitness. Med Sci Sports Exerc 26(1):112–116PubMed Swain DP, Abernathy KS, Smith CS, Lee SJ, Bunn SA (1994) Target heart rates for the development of cardiorespiratory fitness. Med Sci Sports Exerc 26(1):112–116PubMed
Zurück zum Zitat Thomas N, Alder E, Leese GP (2004) Barriers to physical activity in patients with diabetes. Postgrad Med J 80(943):287–291PubMedPubMedCentral Thomas N, Alder E, Leese GP (2004) Barriers to physical activity in patients with diabetes. Postgrad Med J 80(943):287–291PubMedPubMedCentral
Zurück zum Zitat Tjønna AE, Lee SJ, Rognmo Ø, Stølen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slørdahl SA, Kemi OJ, Najjar SM, Wisløff U (2008) Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 118(4):346–354PubMedPubMedCentral Tjønna AE, Lee SJ, Rognmo Ø, Stølen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slørdahl SA, Kemi OJ, Najjar SM, Wisløff U (2008) Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 118(4):346–354PubMedPubMedCentral
Zurück zum Zitat UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 352(9131):837–853 UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 352(9131):837–853
Zurück zum Zitat Venables MC, Achten J, Jeukendrup AE (1985) Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Physiol 98(1):160–167 (Epub 27 Aug 2004) Venables MC, Achten J, Jeukendrup AE (1985) Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Physiol 98(1):160–167 (Epub 27 Aug 2004)
Zurück zum Zitat Wang E, Næss MS, Hoff J, Albert TL, Pham Q, Richardson RS, Helgerud J (2014) Exercise-induced changes in metabolic capacity with age: the role of central cardiovascular plasticity. Age 36(2):665–676PubMed Wang E, Næss MS, Hoff J, Albert TL, Pham Q, Richardson RS, Helgerud J (2014) Exercise-induced changes in metabolic capacity with age: the role of central cardiovascular plasticity. Age 36(2):665–676PubMed
Zurück zum Zitat Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN (2000) Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 132(8):605–611PubMed Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN (2000) Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 132(8):605–611PubMed
Zurück zum Zitat Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97(18):1837–1847PubMed Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97(18):1837–1847PubMed
Zurück zum Zitat Wing RR (2002) Exercise and weight control. In: Ruderman N, Devlin JT, Schneider SH, Kriska A (eds) Handbook of exercise in diabetes. American Diabetes Association, Alexandria, pp 355–364 Wing RR (2002) Exercise and weight control. In: Ruderman N, Devlin JT, Schneider SH, Kriska A (eds) Handbook of exercise in diabetes. American Diabetes Association, Alexandria, pp 355–364
Zurück zum Zitat Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115(24):3086–3094PubMed Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115(24):3086–3094PubMed
Metadaten
Titel
High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes
verfasst von
Eva Maria Støa
Sondre Meling
Lill-Katrin Nyhus
Glenn Strømstad
Karl Magnus Mangerud
Jan Helgerud
Solfrid Bratland-Sanda
Øyvind Støren
Publikationsdatum
03.02.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 3/2017
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-017-3540-1

Weitere Artikel der Ausgabe 3/2017

European Journal of Applied Physiology 3/2017 Zur Ausgabe

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Open Access ADHS Leitthema

Die Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung (ADHS) ist eine der häufigsten psychischen Störungen im Kindes- und Jugendalter [ 1 ]. In Deutschland beträgt die Prävalenz einer elternberichteten ADHS-Diagnose bei Kindern und Jugendlichen 4,4 % …

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Open Access Leitthema

Die Begrenzung von Schäden durch Substanzkonsum und andere abhängige Verhaltensweisen von Jugendlichen und jungen Erwachsenen ist ein wichtiges Anliegen der öffentlichen Gesundheit. Der Übergang von der Adoleszenz zum jungen Erwachsenenalter ist …

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Leitthema

In der Öffentlichkeit wird die berufliche Ausbildung oftmals unter ökonomischen Gesichtspunkten diskutiert: Mit den geburtenstarken Jahrgängen gehen erfahrene Fachkräfte in Rente und von nachfolgenden Generationen rücken zu wenige Arbeitskräfte …

Rauschtrinken in der frühen Adoleszenz

COVID-19 Leitthema

Alkohol ist in Deutschland die mit Abstand am häufigsten konsumierte psychoaktive Substanz. Mehr als 2 Drittel aller Erwachsenen im Alter von 18 bis 64 Jahren (70,5 %) hat 2021 in den letzten 30 Tagen Alkohol konsumiert [ 1 ]. Von diesen …