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Erschienen in:

01.03.2004 | Original Paper

Histological features of peripilar signs associated with androgenetic alopecia

verfasst von: Claire Deloche, Olivier de Lacharrière, Cosimo Misciali, Bianca Maria Piraccini, Colombina Vincenzi, Philippe Bastien, Isabelle Tardy, Bruno A. Bernard, Antonella Tosti

Erschienen in: Archives of Dermatological Research | Ausgabe 10/2004

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Abstract

Background

A study of the scalp in a large cohort of volunteers with androgenetic alopecia using macrophotographs showed the presence of peripilar signs (PPS) around the hair ostia.

Objective

The aim of the present study was to establish the histopathological features related to PPS.

Design

Prospective clinicopathological study.

Setting

Department of Dermatology, University Hospital of Bologna.

Patients

A group of 40 patients (21 males and 19 females) participated in the study. Macrophotographs of the scalp were taken using a Dermaphot camera and PPS were scored using a three-point scale. Hair density and PPS were clinically scored according to reference scales. Two punch biopsies from the photographed area were obtained from each subject and histological analysis was performed on vertical and horizontal sections.

Observations

Clinical parameters indicated that PPS were already detectable on scalp with high hair density. Moreover, in patients with high hair density (score >4), a significant relationship was found between the PPS score and the global score for perifollicular infiltrates. Thus PPS are linked to superficial perifollicular lymphocytic infiltrates in early androgenetic alopecia.

Conclusions

PPS could be the clinical signs reflecting the presence of perifollicular infiltrates.

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Titel: Histological features of peripilar signs associated with androgenetic alopecia
verfasst von: Claire Deloche
Olivier de Lacharrière
Cosimo Misciali
Bianca Maria Piraccini
Colombina Vincenzi
Philippe Bastien
Isabelle Tardy
Bruno A. Bernard
Antonella Tosti
Publikationsdatum: 01.03.2004
Verlag: Springer-Verlag
Erschienen in: Archives of Dermatological Research / Ausgabe 10/2004
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-003-0447-y

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Histological features of peripilar signs associated with androgenetic alopecia