nach oben

Erschienen in:

22.08.2016 | Gynecologic Oncology

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

verfasst von: Giuseppe Santoro, Antonio Simone Laganà, Antonio Micali, Valeria Barresi, Valentina Giacobbe, Vittorio Palmara

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Placental site trophoblastic tumor (PSTT) is a form of gestational trophoblastic disease that originates from the implantation of an intermediate trophoblast. It was described for the first time by Von F. Marchand in 1895 as belonging to chorioepithelioma sui generis, a pathological condition with many variations and a progressive degree of malignancy.

Methods

We have conducted a literature review in MEDLINE about epidemiology, etiopathogenesis and clinical features of PSTT. Moreover, a case that occurred in our institution was reported.

Results

Our research has highlighted that existing published data about PSTT are not uniform. The number of cases described in the literature has updated and the clinical features of selected “case series” of patients diagnosed with PSTT were showed. The etiopathogenesis was discussed. It was noted that current prognostic factors still allow important information regarding PSTT to be obtained, albeit fragmentary.

Conclusions

The lack of uniformity in data collection seen so far has limited full knowledge of PSTT. For this reason, we suggest a model (PSTT model) that collects and unifies PSTT evidence as this would be useful to identify worldwide precise prognostic factors, which are still lacking. When PSTT is diagnosed, the proper procedure seems to be total hysterectomy, with sampling of pelvic lymph nodes and ovarian conservation. For advanced-stage diseases, (stage III and IV) a combination of surgery and polychemotherapy is suggested.

Qin J, Ying W, Cheng X, Wu X, Lu B, Liang Y, Wang X, Wan X, Xie X, Wn Lu (2014) A well-circumscribed border with peripheral doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. PLoS One 9(11):e112618. doi:10.1371/journal.pone.0112618 PubMedPubMedCentralCrossRef

Hyman DM, Bakios L, Gualtiere G, Carr C, Grisham RN, Makker V, Sonoda Y, Aghajanian C, Jewell EL (2013) Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. Gynecol Oncol 129(1):58–62. doi:10.1016/j.ygyno.2012.12.029 PubMedCrossRef

Saso S, Haddad J, Ellis P, Lindsay I, Sebire NJ, McIndoe A, Seckl MJ, Smith JR (2012) Placental site trophoblastic tumours and the concept of fertility preservation. BJOG 119(3):369–374. doi:10.1111/j.1471-0528.2011.03230.x PubMedCrossRef

Lybol C, Thomas CM, Bulten J, van Dijck JA, Sweep FC, Massuger LF (2011) Increase in the incidence of gestational trophoblastic disease in The Netherlands. Gynecol Oncol 121(2):334–338. doi:10.1016/j.ygyno.2011.01.002 PubMedCrossRef

Arató G, Fülöp V, Degrell P, Szigetvári I (2000) Placental site trophoblastic tumor. Clinical and pathological report of two cases. Pathol Oncol Res 6(4):292–294PubMedCrossRef

Renaud F, Llinares K, Golfier F, Devisme L (2015) Curative surgery for placental site trophoblastic tumors. Int J Gynaecol Obstet 130(1):84–85. doi:10.1016/j.ijgo.2015.01.006 PubMedCrossRef

Zheng Y, Bao L, Ning Y, Lu X, Hua K, Yi X (2015) Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China. Int J Gynaecol Obstet 129(1):67–70. doi:10.1016/j.ijgo.2014.10.027 PubMedCrossRef

De Miguel JR, Quintana R, González-Rodilla I, Odriozola JM, Schneider J (2014) Exaggerated placental site/placental site trophoblastic tumor: an underestimated risk factor for emergency peripartum hysterectomy. Clin Exp Obstet Gynecol 41(6):638–640PubMed

Zhao J, Xiang Y, Guo L, Wan X, Feng F, Ren T (2014) Reservation of fertility for seventeen patients with placental site trophoblastic tumor. Zhonghua Fu Chan Ke Za Zhi 49(4):265–269PubMed

10.

Braga A, Uberti EM, Fajardo Mdo C, Viggiano M, Sun SY, Grillo BM, Padilha SL, de Andrade JM, de Souza CB, Madi JM, Maestá I, Silveira E (2014) Epidemiological report on the treatment of patients with gestational trophoblastic disease in 10 Brazilian referral centers: results after 12 years since International FIGO 2000 Consensus. J Reprod Med 59(5–6):241–247PubMed

11.

Ozalp SS, Telli E, Oge T, Tulunay G, Boran N, Turan T, Yenen M, Kurdoglu Z, Ozler A, Yuce K, Ulker V, Arvas M, Demirkiran F, Bese T, Tokgozoglu N, Onan A, Sanci M, Gokcu M, Tosun G, Dikmen Y, Ozsaran A, Terek MC, Akman L, Yetimalar H, Kilic DS, Gungor T, Ozgu E, Yildiz Y, Kokcu A, Kefeli M, Kuruoglu S, Yuksel H, Guvenal T, Hasdemir PS, Ozcelik B, Serin S, Dolanbay M, Arioz DT, Tuncer N, Bozkaya H, Guven S, Kulaksiz D, Varol F, Yanik A, Ogurlu G, Simsek T, Toptas T, Dogan S, Camuzoglu H, Api M, Guzin K, Caliskan E, Doger E, Cakmak B, Ilhan TT (2014) Multicenter analysis of gestational trophoblastic neoplasia in Turkey. Asian Pac J Cancer Prev 15(8):3625–3628. doi:10.7314/APJCP.2014.15.8.3625 PubMedCrossRef

12.

Moutte A, Doret M, Hajri T, Peyron N, Chateau F, Massardier J, Duvillard P, Raudrant D, Golfier F (2013) Placental site and epithelioid trophoblastic tumours: diagnostic pitfalls. Gynecol Oncol 128(3):568–572. doi:10.1016/j.ygyno.2012.11.010 PubMedCrossRef

13.

Bianconi MI, Otero S, Moscheni O, Alvarez L, Storino C, Jankilevich G (2012) Gestational trophoblastic disease: a 21-year review of the clinical experience at an Argentinean public hospital. J Reprod Med 57(7–8):341–349PubMed

14.

Singh M, Kindelberger D, Nagymanyoki Z, Ng SW, Quick CM, Yamamoto H, Fichorova R, Fulop V, Berkowitz RS (2012) Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med 57(5–6):197–203PubMed

15.

Ou-Yang RJ, Hui P, Yang XJ, Zynger DL (2010) Expression of glypican 3 in placental site trophoblastic tumor. Diagn Pathol 5:64. doi:10.1186/1746-1596-5-64 PubMedPubMedCentralCrossRef

16.

Cole LA, Laidler LL, Muller CY (2010) USA hCG reference service, 10-year report. Clin Biochem 43(12):1013–1022. doi:10.1016/j.clinbiochem.2010.05.006 PubMedCrossRef

17.

Lan C, Li Y, He J, Liu J (2010) Placental site trophoblastic tumor: lymphatic spread and possible target markers. Gynecol Oncol 116(3):430–437. doi:10.1016/j.ygyno.2009.10.056 PubMedCrossRef

18.

Schmid P, Nagai Y, Agarwal R, Hancock B, Savage PM, Sebire NJ, Lindsay I, Wells M, Fisher RA, Short D, Newlands ES, Wischnewsky MB, Seckl MJ (2009) Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study. Lancet 374(9683):48–55. doi:10.1016/S0140-6736(09)60618-8 PubMedCrossRef

19.

Feng HC, Tsao SW, Ngan HY, Xue WC, Kwan HS, Siu MK, Liao XY, Wong E, Cheung AN (2008) Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia. Histopathology 52(2):167–174. doi:10.1111/j.1365-2559.2007.02925.x PubMedCrossRef

20.

Piura B, Rabinovich A, Meirovitz M, Shaco-Levy R (2007) Placental site trophoblastic tumor: report of four cases and review of literature. Int J Gynecol Cancer 17(1):258–262PubMedCrossRef

21.

El-Shalakany AH, Kamel KM, Ismail AM, Salah L, El-Deen Fahmy SS, El-Deen Ammar E (2006) Estrogen and progesterone receptors and telomerase enzyme immunohistochemical detection in gestational trophoblastic tumors. Int J Gynecol Cancer 16(5):1918–1926PubMedCrossRef

22.

Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE (2006) Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol 100(3):511–520. doi:10.1016/j.ygyno.2005.08.058 PubMedCrossRef

23.

Moodley M, Marishane T (2005) Demographic variables of gestational trophoblastic disease in KwaZulu-Natal, South Africa. J Obstet Gynaecol 25(5):482–485. doi:10.1080/01443610500171102 PubMedCrossRef

24.

Machtinger R, Gotlieb WH, Korach J, Fridman E, Apter S, Goldenberg M, Ben-Baruch G (2005) Placental site trophoblastic tumor: outcome of five cases including fertility preserving management. Gynecol Oncol 96(1):56–61. doi:10.1016/j.ygyno.2004.08.049 PubMedCrossRef

25.

Ino K, Kikkawa F, Suzuki T, Kajiyama H, Shibata K, Nomura S, Itakura A, Ito M, Nagasaka T, Hattori A, Tsujimoto M, Mizutani S (2003) Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells. Lab Invest 83(12):1799–1809PubMedCrossRef

26.

Chang YL, Chang TC, Hsueh S, Huang KG, Wang PN, Liu HP, Soong YK (1999) Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. Gynecol Oncol 73(2):216–222PubMedCrossRef

27.

Pelkey TJ, Frierson HF Jr, Mills SE, Stoler MH (1999) Detection of the alpha-subunit of inhibin in trophoblastic neoplasia. Hum Pathol 30(1):26–31PubMedCrossRef

28.

Kim SJ, Bae SN, Kim JH, Kim CJ, Han KT, Chung JK, Lee JM (1998) Epidemiology and time trends of gestational trophoblastic disease in Korea. Int J Gynaecol Obstet 60(Suppl 1):S33–S38PubMedCrossRef

29.

Ichikawa N, Zhai YL, Shiozawa T, Toki T, Noguchi H, Nikaido T, Fujii S (1998) Immunohistochemical analysis of cell cycle regulatory gene products in normal trophoblast and placental site trophoblastic tumor. Int J Gynecol Pathol 17(3):235–240PubMedCrossRef

30.

Rhoton-Vlasak A, Wagner JM, Rutgers JL, Baergen RN, Young RH, Roche PC, Plummer TB, Gleich GJ (1998) Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. Hum Pathol 29(3):280–288PubMedCrossRef

31.

Gurian KV, Podratz KC, Elg SA, Twiggs LB, Lurain JR, Wagner JM, Gleich GJ (1996) Major basic protein as a marker of malignant potential in trophoblastic neoplasia. Am J Obstet Gynecol 175(3 Pt 1):632–637PubMedCrossRef

32.

Huang F, Zheng W, Liang Q, Yin T (2013) Diagnosis and treatment of placental site trophoblastic tumor. Int J Clin Exp Pathol 6(7):1448–1451PubMedPubMedCentral

33.

Driscoll SG (1984) Placental-site chorioma. The neoplasm of the implantation-site trophoblast. J Reprod Med 29(11):821–825PubMed

34.

Zhou Y, Lu H, Yu C, Tian Q, Lu W (2013) Sonographic characteristics of placental site trophoblastic Tumor. Ultrasound Obstet Gynecol 41:679–684. doi:10.1002/uog.12269 PubMedCrossRef

35.

Rauw L, Delbecque K, Goffin F, Golfier F, Georges P, Kridelka F (2013) Atypical recurrence of a placental site trophoblastic tumor 4 years after hysterectomy for benign condition: case report and review of literature. Gynecol Oncol Case Rep 6:36–38. doi:10.1016/j.gynor.2013.05.006 PubMedPubMedCentralCrossRef

36.

Vardar MA, Altintas A (1995) Placental-site trophoblastic tumor. Principles of diagnosis, clinical behaviour and treatment. Eur J Gynaecol Oncol 16(4):290–295PubMed

37.

How J, Scurry J, Grant P, Sapountzis K, Ostor A, Fortune D, Armes J (1995) Placental site trophoblastic tumor. Report of three cases and review of the literature. Int J Gynecol Cancer 5(4):241–249PubMedCrossRef

38.

Hopkins MP, Drescher CW, McQuillan A, Keyser J, Schmidt R (1992) Malignant placental site trophoblastic tumor associated with placental abruption, fetal distress, and elevated CA-125. Gynecol Oncol 47:267–271PubMedCrossRef

39.

Su YN, Cheng WF, Chen CA, Lin TY, Hsieh FJ, Cheng SP, Hsieh CY (1999) Pregnancy with primary tubal placental site trophoblastic tumor-a case report and literature review. Gynecol Oncol 73:322–325PubMedCrossRef

40.

Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F (2014) Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. Gynecol Oncol Case Rep 9:3–6. doi:10.1016/j.gynor.2014.04.001 PubMedPubMedCentralCrossRef

41.

Soma H, Okada T, Yoshinari T, Furuno A, Yaguchi S, Tokoro K, Kato H (2004) Placental site trophoblastic tumor of the uterine cervix occurring from undetermined antecedent pregnancy. J Obstet Gynaecol Res 30:113–116. doi:10.1111/j.1447-0756.2003.00169.x PubMedCrossRef

42.

Wang D, He Y, Hu Y, Xie C, Yin R (2010) Placental site trophoblastic tumor with unusual presentation in the uterine cervix. Eur J Obstet Gynecol Reprod Biol 148(1):100–101. doi:10.1016/j.ejogrb.2009.09.013 PubMedCrossRef

43.

El Hag IA, Ramesh K, Kollur SM, Salem M (2002) Extrauterine placental site trophoblastic tumour in association with a lithopedion. Histopathology 41:446–449. doi:10.1046/j.1365-2559.2002.01450.x PubMedCrossRef

44.

Arroyo MR, Podda A, Cao D, Rodriguez MM (2009) Placental site trophoblastic tumor in the ovary of a young child with isosexual precocious puberty. Pediatr Dev Pathol 2:73–76. doi:10.2350/08-05-0462.1 CrossRef

45.

Suurmeijer AJ, Gietema JA, Hoekstra HJ (2004) Placental site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis. Am J Surg Pathol 28:830–833PubMedCrossRef

46.

Idrees MT, Kao CS, Epstein JI, Ulbright TM (2015) Nonchoriocarcinomatous trophoblastic tumors of the testis: the widening spectrum of trophoblastic neoplasia. Am J Surg Pathol 39(11):1468–1478. doi:10.1097/PAS.0000000000000509 PubMedCrossRef

47.

Monclair T, Abeler VM, Kaern J, Walaas L, Zeller B, Hilstrøm C (2002) Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy. Med Pediatr Oncol 38(3):187–191PubMedCrossRef

48.

Went PT, Dirnhofer S, Stallmach T, Taverna C, Singer G (2005) Placental site trophoblastic tumor of the mediastinum. Hum Pathol 36(5):581–584. doi:10.1016/j.humpath.2005.02.020 PubMedCrossRef

49.

Ulbright TM, Young RH, Scully RE (1997) Trophoblastic tumors of the testis other than classic choriocarcinoma: “monophasic” choriocarcinoma and placental site trophoblastic tumor: a report of two cases. Am J Surg Pathol 21(3):282–288PubMedCrossRef

50.

Bayram I, Senol S, Ozen S, Sahin GH (2007) Placental site trophoblastic tumor and concomitant primary ovarian leiomyoma in a postmenopausal woman. Am J Clin Oncol 30(1):97–98. doi:10.1097/01.coc.0000183969.65544.1f PubMedCrossRef

51.

Zhang X, Zhou C, Yu M, Chen X (2015) Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. Int J Clin Exp Pathol 8(6):7254–7259PubMedPubMedCentral

52.

Shih IM, Kurman RJ (1998) Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarci-noma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 22:1393–1403PubMedCrossRef

53.

Chen BJ, Cheng CJ, Chen WY (2013) Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report. Diagn Pathol 8:85. doi:10.1186/1746-1596-8-85 PubMedPubMedCentral

54.

Leow WQ, Loh HL, Lee LS, Goh CH (2015) A rare case of combined placental site trophoblastic tumour with mature cystic teratoma and mixed germ cell tumour in the testis. Malays J Pathol 37(2):145–147PubMed

55.

Petersson F, Grossmann P, Vanecek T, Coric M, Cacic M, Hes O, Michal M (2010) Testicular germ cell tumor composed of placental site trophoblastic tumor and teratoma. Hum Pathol 41(7):1046–1050. doi:10.1016/j.humpath.2009.10.026 PubMedCrossRef

56.

Xiao C, Zhao J, Li M, Zhao D, Xiang Y (2014) Lupus nephritis associated with placental site trophoblastic tumor: a case report and review of the literature. Gynecol Oncol Case Rep 9:26–28. doi:10.1016/j.gynor.2014.05.003 PubMedPubMedCentralCrossRef

57.

Mazzucco G, Colla L, Monga G (2011) Kidney involvement in a patient affected by placental site trophoblastic tumor. Am J Kidney Dis 57:516–520. doi:10.1053/j.ajkd.2010.11.019 PubMedCrossRef

58.

Batra V, Kalra OP, Mathur P, Kavita Dev G (2007) Membranous glomerulopathy associated with placental site trophoblastic tumour: a case report. Nephrol Dial Transplant 22:1766–1768PubMedCrossRef

59.

Nagelberg SB, Rosen SW (1985) Clinical and laboratory investigation of a virilized woman with placental trophoblastic tumour. Obstet Gynecol 65(4):527–534PubMed

60.

Denny LA, Dehaeck K, Nevin J, Soeters R, van Wijk AL, Megevand E, Bloch B (1995) Placental site trophoblastic tumor: three case report and literature review. Gynecol Oncol 59(2):300–303PubMedCrossRef

61.

Young RH, Scully RE, McCluskey RT (1985) A distinctive glomerular lesion complicating placental site trophoblastic tumor: report of two cases. Hum Pathol 6:35–42CrossRef

62.

Cole ME, Broaddus R, Thaker P, Landen C, Freedman RS (2008) Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. Nat Clin Pract Oncol 5(3):171–175. doi:10.1038/ncponc1042 PubMedCrossRef

63.

Hassadia A, Gillespie A, Tidy J, Everard RGNJ, Wells M, Coleman R, Hancock B (2005) Placental site trophoblastic tumour: clinical features and management. Gynecol Oncol 99(3):603–607. doi:10.1016/j.ygyno.2005.06.054 PubMedCrossRef

64.

Hui P, Parkash V, Perkins AS, Carcangiu ML (2000) Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome. Lab Invest 80(6):965–972PubMedCrossRef

65.

Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, Sklar J, Yang XJ, Soslow RA (2007) Absence of Y chromosome in human placental site trophoblastic tumor. Mod Pathol 20:1055–1060. doi:10.1038/modpathol.3800941 PubMedCrossRef

66.

Muller-Hocker J, Obernitz N, Johannes A, Löhrs U (1997) p53 gene product and EGF receptors are highly expressed in placental site trophoblastic tumor. Hum Pathol 28(11):1302–1306PubMedCrossRef

67.

Wells M (2007) The pathology of gestational trophoblastic disease: recent advances. Pathology 39:88–96. doi:10.1080/00313020601137367 PubMedCrossRef

68.

Golfier F, Clerc J, Hajri T, Massardier J, Frappart L, Duvillard P, Rabreau M, Patrier S, Devisme L, Carles D, Pelluard F, Gasser B, Tarranger-Charpin C, Schott AM, Raudrant D (2011) Contribution of referent pathologists to the quality of trophoblastic diseases diagnosis. Hum Reprod 26(10):2651–2657. doi:10.1093/humrep/der265 PubMedCrossRef

69.

Agarwal N, Parul Kriplani A, Vijayaraghavan M (2002) Placental site trophoblastic tumour. J Postgrad Med 48(3):211–212PubMed

70.

Luiza JW, Taylor SE, Gao FF, Edwards RP (2013) Placental site trophoblastic tumor: immunohistochemistry algorithm key to diagnosis and review of literature. Gynecol Oncol Case Rep 7:13–15. doi:10.1016/j.gynor.2013.11.001 PubMedPubMedCentralCrossRef

71.

Shih IM, Kurman RJ (2002) Molecular basis of gestational trophoblastic diseases. Curr Mol Med 2(1):1–12. doi:10.2174/1566524023362960 PubMedCrossRef

72.

Piura B (2006) Placental site trophoblastic tumor e a challenging rare entity. Eur J Gynaecol Oncol 27(6):545–551PubMed

73.

Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW (2006) Radiology of gestational trophoblastic neoplasia. Clin Radiol 61(4):301–313. doi:10.1016/j.crad.2005.12.003 PubMedCrossRef

74.

Chang TC, Yen TC, Li YT, Wu YC, Chang YC, Ng KK, Jung SM, Wu TI, Lai CH (2006) The role of 18F-fluorodeoxyglucose positron emission tomography in gestational trophoblastic tumours: a pilot study. Eur J Nucl Med Mol Imaging 33(2):156–163. doi:10.1007/s00259-005-1873-1 PubMedCrossRef

75.

Lurain JR (2002) Treatment of gestational trophoblastic tumors. Curr Treat Options Oncol 3(2):113–124PubMedCrossRef

76.

Chen Y, Zhang X, Xie X (2011) Clinical features of 17 cases of placental site trophoblastic tumor. Int J Gynaecol Obstet 115(2):204–205. doi:10.1016/j.ijgo.2011.06.008 PubMedCrossRef

77.

van Trommel NE, Lok CA, Bulten H, Thomas CM, Massuger LF (2013) Long-term outcome of placental site trophoblastic tumor in The Netherlands. J Reprod Med 58(5–6):224–228PubMed

78.

Liszka L, Wilk M, Wodolazski A, Palen P, Sikora J (2009) Successful treatment of placental site trophoblastic tumor in twin pregnancy without hysterectomy. Tumori 95:108–111PubMed

79.

Xue WC, Guan XY, Ngan HY, Shen DH, Khoo US, Cheung AN (2002) Malignant placental site trophoblastic tumor, a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization. Cancer 94(8):2288–2294PubMedCrossRef

80.

Kurman RJ, Scully RE, Norris HJ (1976) Trophoblastic pseudotumor of the uterus: an exaggerated form of “syncytial endometritis” simulating a malignant tumor. Cancer 38:1214–1219PubMedCrossRef

81.

Twiggs LB, Okagaki T, Phillips GL, Stroemer JR, Adcock LL (1981) Trophoblastic pseudotumor: evidence of malignant disease potential. Gynecol Oncol 12:238–243PubMedCrossRef

82.

Scully RE, Young RH (1981) Trophoblastic pseudotumor: a reappraisal. Am J Surg Pathol 5:75–81PubMedCrossRef

83.

Huber H, Hormann AG (1954) Malignant chorioepithelioma and chorioepitheliosis. Gynecol Prat 5(1):31–40PubMed

84.

Kehrer E (1956) Pathology of trophoblast development; chorioepithelioma malignum and chorioepitheliosis. Z Geburtshilfe Gynakol 147(2):145–203PubMed

85.

Cruz H, Fischer O, Guzman A (1966) Chorioepitheliosis. Rev Chil Obstet Ginecol 31(4):200–209PubMed

86.

Hui P (ed) (2012) Placental site trophoblastic tumor. Gestational trophoblastic disease: diagnostic and molecular genetic pathology. Humana Press, New York, pp 91–103

87.

Cole LA, Dai D, Butler SA, Leslie KK, Kohorn EI (2006) Gestational trophoblastic diseases: pathophysiology of hyperglycosylated hCG. Gynecol Oncol 102(2):145–150. doi:10.1016/j.ygyno.2005.12.047 PubMedCrossRef

88.

IeM Shih (2007) Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumor like lesions. Ann Diagn Pathol 11(3):228–234. doi:10.1016/j.anndiagpath.2007.04.001 CrossRef

89.

Jain KA (2005) Gestational trophoblastic disease: pictorial review. Ultrasound Q 21(4):245–253PubMedCrossRef

90.

Kani KK, Lee JH, Dighe M, Moshiri M, Kolokythas O, Dubinsky T (2012) Gestatational trophoblastic disease: multimodality imaging assessment with special emphasis on spectrum of abnormalities and value of imaging in staging and management of disease. Curr Probl Diagn Radiol 41(1):1–10. doi:10.1067/j.cpradiol.2011.06.002 PubMedCrossRef

91.

Wagner BJ, Woodward PJ, Dickey GE (1996) From the archives of the AFIP. Gestational trophoblastic disease: radiologic-pathologic correlation. Radiographics 16(1):131–148PubMedCrossRef

92.

Sironi S, Picchio M, Mangili G, Garavaglia E, Zangheri B, Messa C, Voci C, Taccagni GL, del Maschio A, Fazio F (2003) [18F] fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumour: preliminary results in three patients. Gynecol Oncol 91(1):226–230. doi:10.1016/S0090-8258(03)00437-2 PubMedCrossRef

93.

FIGO Oncology Committee (2002) FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int J Gynaecol Obstet 77(3):285–287. doi:10.1016/S0020-7292(02)00063-2 CrossRef

94.

Savage P, Cooke R, O’Nions J, Krell J, Kwan A, Camarata M, Dancy G, Short D, Seckl MJ, Swerdlow A (2015) Effects of single-agent and combination chemotherapy for gestational trophoblastic tumors on risks of second malignancy and early menopause. J Clin Oncol 33(5):472–478. doi:10.1200/JCO.2014.57.5332 PubMedCrossRef

95.

Marchand F (1895) Uber die sogenannten”decidualen” geschwulste im Anschloss an normale Gebart, Abort, Blasenmole, und Extrauterin Schwangerschaft. Monatsschr Geburtshilfe Gynaekol 1:419

96.

Marchand F (1898) Ueber das maligne chorionepitheliome netsi mittheilung. Zeitschft f Geburtsch u Gynak 39:173–215

97.

Ewing J (1908) Chorioepithelioma. Am J Obst 57:41

98.

Ewing J (1910) Chorioma: a clinical and pathological study. Surg Gynecol Obst 10:366–391

99.

Heath RS (1937) Chorionepithelioma of the uterus. University of Nebraska Medical Center, College of Medicine, MD Theses. Paper 514:1–54

100.

Santoro G, Laganà AS, Sturlese E, Giacobbe V, Retto A, Palmara V (2014) Developmental and Clinical Overview of Lithopaidion. Gynecol Obstet Invest 78:213–223. doi:10.1159/000358828 PubMedCrossRef

101.

Guzeloglu-Kayisli O, Kayisli UA, Taylor HS (2009) The role of growth factors and cytokines during implantation: endocrine and paracrine interactions. Semin Reprod Med 27(1):62–79. doi:10.1055/s-0028-1108011 PubMedPubMedCentralCrossRef

102.

Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C, ESMO Guidelines Working Group (2013) Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(6):vi39–vi50. doi:10.1093/annonc/mdt345 PubMed

103.

Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, Ngan HY, Golfier F, Sekharan PK, Charry RC, Poveda A, Kim JW, Xiang Y, Berkowtiz R, Seckl MJ (2014) Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer 24:S109–S116. doi:10.1097/IGC.0000000000000294 PubMedCrossRef

Titel: Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside
verfasst von: Giuseppe Santoro
Antonio Simone Laganà
Antonio Micali
Valeria Barresi
Valentina Giacobbe
Vittorio Palmara
Publikationsdatum: 22.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4182-y

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

Abstract

Introduction

Methods

Results

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Randomized double-blind placebo controlled study of preinduction cervical priming with 25 µg of misoprostol in the outpatient setting to prevent formal induction of labour

Pattern of metastatic spread and subcategories of breast cancer

New associate Editor Prof. Dr. J. Sehouli for the section Gynecologic Oncology

Laparoscopic management of ectopic pregnancies: a comparison between interstitial and “more distal” tubal pregnancies

Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

Calculation of optimal gestation weight gain in pre-pregnancy underweight women due to body mass index change in relation to mother’s height

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie