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26.03.2021 | Original Article

History of Diverticulitis and Risk of Incident Cardiovascular Disease in Men: A Cohort Study

verfasst von: Idy Tam, Po-Hong Liu, Wenjie Ma, Yin Cao, Manol Jovani, Kana Wu, Eric B. Rimm, Lisa L. Strate, Edward L. Giovannucci, Andrew T. Chan

Erschienen in: Digestive Diseases and Sciences | Ausgabe 4/2022

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Abstract

Background

Diverticulitis and cardiovascular disease (CVD) are two highly prevalent disorders sharing common risk factors which are hypothesized to have an inflammatory basis.

Aims

To examine the association between history of diverticulitis and risk of incident CVD.

Methods

We conducted a prospective cohort study of 43,904 men aged 40 to 75 years without a history of CVD (fatal or nonfatal myocardial infarction and stroke) at enrollment who were followed up from 1986 to 2012 in the Health Professionals Follow-Up Study. Lifestyle factors, dietary intake, and disease information were self-reported biennially or quadrennially. Incident diverticulitis and CVD were confirmed by review of medical records. We used Cox proportional hazard models to calculate age- and multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) of incident CVD. We conducted a stratified analysis according to the presence or absence of CVD risk factors (smoking, hypertension, hyperlipidemia, and diabetes).

Results

We identified 3848 incident cases of CVD during 856,319 person-years of follow-up. Men with diverticulitis had higher incidence of CVD (727 cases per 100,000 person-years) compared to men without diverticulitis [446 cases per 100,000 person-years, multivariate HR of 1.35 (95% CI 1.07–1.70)]. The association of diverticulitis and subsequent CVD appeared more evident among men without known CVD risk factors (HR 4.06, 95% CI 2.04–8.08) compared to those with one or more CVD risk factors (HR 1.27, 95% CI 0.98–1.63).

Conclusions

Diverticulitis may be an independent risk factor of incident CVD, suggesting possible common etiopathogenic mechanisms. Diagnosis of diverticulitis underscores the importance of preventive measures to reduce future CVD.

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Titel: History of Diverticulitis and Risk of Incident Cardiovascular Disease in Men: A Cohort Study
verfasst von: Idy Tam
Po-Hong Liu
Wenjie Ma
Yin Cao
Manol Jovani
Kana Wu
Eric B. Rimm
Lisa L. Strate
Edward L. Giovannucci
Andrew T. Chan
Publikationsdatum: 26.03.2021
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 4/2022
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-021-06949-9

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History of Diverticulitis and Risk of Incident Cardiovascular Disease in Men: A Cohort Study