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CardioVascular and Interventional Radiology

Erschienen in:

12.09.2022 | Laboratory Investigation

Histotripsy of Subcutaneous Fat in a Live Porcine Model

verfasst von: John F. Swietlik, Emily A. Knott, Katherine C. Longo, Annie M. Zlevor, Xiaofei Zhang, Paul F. Laeseke, Scott B. Reeder, Zhen Xu, Fred T. Lee Jr, Timothy J. Ziemlewicz

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 1/2023

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Abstract

Purpose

This study was designed to evaluate the feasibility and safety of histotripsy subcutaneous (SQ) fat treatment in an in-vivo porcine model, and evaluate evolution of the treated volume on MRI and pathology.

Methods/Materials

10 histotripsy SQ fat treatments were completed in 5 swine, divided into four groups based on pre-determined survival: day 0 (n = 4), day 7 (n = 2), day 28 (n = 2), and day 56 (n = 2). A 4.0 × 4.0x2.0 cm ovoid treatment was created in the fat pad of the posterior thorax. MRI of survived animals were obtained on day 7 (n = 6), day 28 (n = 4), and day 56 (n = 2), and reviewed for size and imaging characteristics. Technical success was defined as the creation of a treatment zone in the targeted SQ fat. Skin firmness and indentation were qualitatively scored.

Results

Histotripsy had a 100% (10/10) technical success for creation of SQ fat treatments. Mean treatment time was 35.5 min (range 35–36.5). The volume of treated SQ fat demonstrated 92% volume reduction over the study. Day 0 gross pathology treatment had a mean volume of 12.6 cm³ (± 2.1) (prescribed volume of 16.7 cm³), which decreased to 8.3 cm³ (± 2.8) by day 7 (34% overall decrease), 3.0 cm³ (± 0.5) by day 28 (76% overall decrease), and 1.0 cm³ (± 1.2) by day 56 (92% overall decrease). Mean firmness and indentation scores showed no change from baseline at all time points, with no overlying skin injury.

Conclusion

Histotripsy safely and effectively treated SQ fat of an in-vivo porcine model, with volume reduction over time.

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Titel: Histotripsy of Subcutaneous Fat in a Live Porcine Model
verfasst von: John F. Swietlik
Emily A. Knott
Katherine C. Longo
Annie M. Zlevor
Xiaofei Zhang
Paul F. Laeseke
Scott B. Reeder
Zhen Xu
Fred T. Lee Jr
Timothy J. Ziemlewicz
Publikationsdatum: 12.09.2022
Verlag: Springer US
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 1/2023
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-022-03262-4

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Histotripsy of Subcutaneous Fat in a Live Porcine Model