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Current Hepatology Reports

Erschienen in:

15.11.2019 | Fatty Liver Disease (V Ajmera, Section Editor)

HIV-Associated NAFLD: Disease Burden and Management

verfasst von: Alyson Kaplan, Jennifer C. Price

Erschienen in: Current Hepatology Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

Highly potent anti-retroviral therapy (ART) for the treatment of human immunodeficiency virus (HIV) has led to dramatic improvements in quality of life and lifespan in persons living with HIV (PLWH). PLWH, however, are suffering from other comorbid conditions, including non-alcoholic fatty liver disease (NAFLD). This review summarizes the epidemiology and pathophysiology of NAFLD in PLWH and explores unique diagnostic and treatment considerations in this population.

Recent Findings

Though it is well established that there is a high prevalence of NAFLD in PLWH, the mechanisms underlying NAFLD in this population are just beginning to be explored. Traditional NAFLD risk factors, including insulin resistance, visceral adiposity, and genetics, have been consistently linked with NAFLD in PLWH. In addition, HIV-related factors including mitochondrial dysfunction, microbiome alterations, and direct effects of the virus and of ART may play a role.

Summary

Given the burden of NAFLD in PLWH, further studies are necessary to investigate mechanisms specific to HIV with which to target therapies.

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Titel: HIV-Associated NAFLD: Disease Burden and Management
verfasst von: Alyson Kaplan
Jennifer C. Price
Publikationsdatum: 15.11.2019
Verlag: Springer US
Erschienen in: Current Hepatology Reports / Ausgabe 4/2019
Elektronische ISSN: 2195-9595
DOI: https://doi.org/10.1007/s11901-019-00501-0

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